1. Gene
  2. BRI3 - brain protein I3 Gene

BRI3 - brain protein I3 Gene

Homo sapiens

Also known as I3

Gene ID: 25798 | Gene type: protein coding

About BRI3

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:98,281,686-98,323,430 (from NCBI)

This gene has 7 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in lung (RPKM 12.8), stomach (RPKM 11.3) and 25 other tissues.

Summary

Enables identical protein binding activity. Predicted to be located in azurophil granule membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

BRI3 Products(2)

mRNA Protein Name
NM_001159491.2 NP_001152963.1 brain protein I3 isoform b
NM_015379.5 NP_056194.1 brain protein I3 isoform a
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IDA
IDA: Inferred from direct assay
15606899 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11860200 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRI3 Protein Structure

DUF2367

DUF2367: Uncharacterized conserved protein (DUF2367) (28 - 124)

  • 0
  • 100
  • 125 a.a.
Protein Preferred Names Protein Names

brain protein I3

pRGR2

BRI3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
BRI3 O95415 ABHD16A Homo sapiens O95870
Validated Y2H
32296183
Intra
BRI3 O95415 BRI3BP Homo sapiens Q8WY22
Anti Tag CoIP
30983867
Intra
BRI3 O95415 BRI3BP Homo sapiens Q8WY22
Y2H
11860200
Intra
BRI3 O95415 MGAT1 Homo sapiens P26572
Confocal
30983867
Intra
BRI3 O95415 MGAT1 Homo sapiens P26572
Anti Tag CoIP
30983867
Intra
BRI3 O95415 MGAT1 Homo sapiens P26572
Y2H
30983867
Intra
BRI3 O95415 MALL Homo sapiens Q13021
Validated Y2H
32296183
Intra
BRI3 O95415 IFITM3 Homo sapiens Q01628
Anti Tag CoIP
30983867
Intra
BRI3 O95415 IFITM3 Homo sapiens Q01628
Confocal
30983867
Intra
BRI3 O95415 IFITM3 Homo sapiens Q01628
Y2H
30983867
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy 45

DEE45

Epileptic Encephalopathy, Early Infantile, 45

Eiee45

Developmental And Epileptic Encephalopathy, 45

Early Infantile Epileptic Encephalopathy 45

Developmental And Epileptic Encephalopathy 46

DEE46

Epileptic Encephalopathy, Early Infantile, 46

Eiee46

Developmental And Epileptic Encephalopathy, 46

Early Infantile Epileptic Encephalopathy 46

Developmental And Epileptic Encephalopathy 49

DEE49

Epileptic Encephalopathy, Early Infantile, 49

Eiee49

Developmental And Epileptic Encephalopathy, 49

Early Infantile Epileptic Encephalopathy 49

Developmental And Epileptic Encephalopathy 34

DEE34

Epileptic Encephalopathy, Early Infantile, 34

Eiee34

Developmental And Epileptic Encephalopathy, 34

Early Infantile Epileptic Encephalopathy 34

Developmental And Epileptic Encephalopathy 42

DEE42

Epileptic Encephalopathy, Early Infantile, 42

Eiee42

Developmental And Epileptic Encephalopathy, 42

Early Infantile Epileptic Encephalopathy 42

Encephalopathy, Epileptic, Early Infantile, Type 42

Developmental And Epileptic Encephalopathy 4

DEE4

Epileptic Encephalopathy, Early Infantile, 4

Eiee4

Early Infantile Epileptic Encephalopathy 4

Stxbp1-Related Early-Onset Encephalopathy

Early Myoclonic Encephalopathy

Developmental And Epileptic Encephalopathy, 4

Stxbp1 Disorders

Stxbp1 Encephalopathy

Developmental And Epileptic Encephalopathy, Type 4

Early-Infantile Epileptic Encephalopathy 4

Stxbp1 Encephalopathy With Epilepsy

Stxbp1 Epileptic Encephalopathy

Stxbp1-Related Developmental And Epileptic Encephalopathy

Stxbp1-Related Epileptic Encephalopathy

Eme

Neonatal Epilepsy With Suppression-Burst Pattern

Encephalopathy, Epileptic, Early Infantile, Type 4

Retinitis Pigmentosa 3

RP3

Retinitis Pigmentosa 15

Rp15

Choroidoretinal Degeneration With Retinal Reflex In Heterozygous Women

Cone-Rod Degeneration, X-Linked

Retinitis Pigmentosa Type 15

X-Linked Cone-Rod Degeneration

X-Linked Retinitis Pigmentosa 3

Xlrp3

Xlrp-3

Retinitis Pigmentosa-3

Retinitis Pigmentosa, Type 3

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus BRI3 VGNC VGNC:26564
Canis familiaris BRI3 VGNC VGNC:38525
Mus musculus BRI3 MGD MGI:1933174
Rattus norvegicus BRI3 RGD RGD:1309187
Macaca mulatta BRI3 VGNC VGNC:70283
Felis catus BRI3 VGNC VGNC:107742