ABHD16A - abhydrolase domain containing 16A, phospholipase Gene

Homo sapiens

Also known as BAT5; NG26; PP199; SPG86; hBAT5; D6S82E

Gene ID: 7920 | Gene type: protein coding

About ABHD16A

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,686,955-31,703,324 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 193 orthologues, 7 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 19.9), prostate (RPKM 13.9) and 25 other tissues.

Summary

A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some aspects of immunity. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

ABHD16A Products(2)

mRNA	Protein	Name
NM_001177515.2	NP_001170986.1	phosphatidylserine lipase ABHD16A isoform b
NM_021160.3	NP_066983.1	phosphatidylserine lipase ABHD16A isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables lysophospholipase activity	IDA IDA: Inferred from direct assay	25290914	GOA
enables monoacylglycerol lipase activity	IDA IDA: Inferred from direct assay	25290914	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14667819	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in monoacylglycerol catabolic process	IDA IDA: Inferred from direct assay	25290914	GOA
involved in prostaglandin catabolic process	IDA IDA: Inferred from direct assay	25290914	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABHD16A Protein Structure

Abhydrolase_5

0
100
200
300
400
500
558 a.a.

Protein Preferred Names

Protein Names

phosphatidylserine lipase ABHD16A

HLA-B associated transcript 5

ABHD16A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ABHD16A	O95870	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	25416956
Intra	ABHD16A	O95870	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	ABHD16A	O95870	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	ABHD16A	O95870	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	25416956
Intra	ABHD16A	O95870	RETREG3	Homo sapiens	Q86VR2	Y2H Array	29892012
Intra	ABHD16A	O95870	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	WBP1L	Homo sapiens	Q9NX94	Validated Y2H	32296183
Intra	ABHD16A	O95870	WBP1L	Homo sapiens	Q9NX94	Y2H Array	32296183
Intra	ABHD16A	O95870	WBP1L	Homo sapiens	Q9NX94	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	AQP7	Homo sapiens	Q6P5T0	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	AQP7	Homo sapiens	Q6P5T0	Validated Y2H	32296183
Intra	ABHD16A	O95870	AQP7	Homo sapiens	Q6P5T0	Y2H Array	32296183
Intra	ABHD16A	O95870	VMA21	Homo sapiens	Q3ZAQ7	Y2H Array	32296183
Intra	ABHD16A	O95870	VMA21	Homo sapiens	Q3ZAQ7	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	VMA21	Homo sapiens	Q3ZAQ7	Validated Y2H	32296183
Intra	ABHD16A	O95870	SPAG4	Homo sapiens	Q9NPE6	Validated Y2H	32296183
Intra	ABHD16A	O95870	SPAG4	Homo sapiens	Q9NPE6	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	SPAG4	Homo sapiens	Q9NPE6	Y2H Array	32296183
Intra	ABHD16A	O95870	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	ABHD16A	O95870	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	ABHD16A	O95870	GDAP1	Homo sapiens	Q8TB36	Y2H Array	32296183
Intra	ABHD16A	O95870	GDAP1	Homo sapiens	Q8TB36	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	GDAP1	Homo sapiens	Q8TB36	Validated Y2H	32296183
Intra	ABHD16A	O95870	RHBDL1	Homo sapiens	O75783	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	RHBDL1	Homo sapiens	O75783	Y2H Array	32296183
Intra	ABHD16A	O95870	PKMYT1	Homo sapiens	Q99640-2	Validated Y2H	32296183
Intra	ABHD16A	O95870	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	ABHD16A	O95870	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	ABHD16A	O95870	SLC7A8	Homo sapiens	Q9UHI5	Validated Y2H	32296183
Intra	ABHD16A	O95870	SLC7A8	Homo sapiens	Q9UHI5	Y2H Array	32296183
Intra	ABHD16A	O95870	SLC7A8	Homo sapiens	Q9UHI5	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	TMEM143	Homo sapiens	Q96AN5	Validated Y2H	32296183
Intra	ABHD16A	O95870	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	ABHD16A	O95870	UNC93A	Homo sapiens	Q86WB7-2	Validated Y2H	32296183
Intra	ABHD16A	O95870	PERP	Homo sapiens	Q96FX8	Validated Y2H	32296183
Intra	ABHD16A	O95870	CYP1A2	Homo sapiens	P05177	Validated Y2H	32296183
Intra	ABHD16A	O95870	GOLT1A	Homo sapiens	Q6ZVE7	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	GOLT1A	Homo sapiens	Q6ZVE7	Validated Y2H	32296183
Intra	ABHD16A	O95870	GOLT1A	Homo sapiens	Q6ZVE7	Y2H Array	32296183
Intra	ABHD16A	O95870	RHBDD2	Homo sapiens	Q6NTF9-3	Validated Y2H	32296183
Intra	ABHD16A	O95870	RHBDD2	Homo sapiens	Q6NTF9-3	Y2H Array	32296183
Intra	ABHD16A	O95870	RHBDD2	Homo sapiens	Q6NTF9-3	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	ABHD16A	O95870	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	ABHD16A	O95870	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	CBARP	Homo sapiens	Q8N350-4	Validated Y2H	32296183
Intra	ABHD16A	O95870	CBARP	Homo sapiens	Q8N350-4	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	CBARP	Homo sapiens	Q8N350-4	Y2H Array	32296183
Intra	ABHD16A	O95870	STMN4	Homo sapiens	Q9H169-2	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	STMN4	Homo sapiens	Q9H169-2	Validated Y2H	32296183
Intra	ABHD16A	O95870	STMN4	Homo sapiens	Q9H169-2	Y2H Array	32296183
Intra	ABHD16A	O95870	ITGAM	Homo sapiens	P11215	Validated Y2H	32296183
Intra	ABHD16A	O95870	ATP5PF	Homo sapiens	P18859	Validated Y2H	32296183
Intra	ABHD16A	O95870	ATP5PF	Homo sapiens	P18859	Y2H Array	32296183
Intra	ABHD16A	O95870	ATP5PF	Homo sapiens	P18859	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	AGPAT3	Homo sapiens	Q9NRZ7	Validated Y2H	32296183
Intra	ABHD16A	O95870	BRI3	Homo sapiens	O95415	Y2H Array	32296183
Intra	ABHD16A	O95870	BRI3	Homo sapiens	O95415	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	RNF5	Homo sapiens	Q99942	Y2H Array	32296183
Intra	ABHD16A	O95870	RNF5	Homo sapiens	Q99942	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	RNF5	Homo sapiens	Q99942	Y2H	14667819
Intra	ABHD16A	O95870	RNF5	Homo sapiens	Q99942	Validated Y2H	32296183
Intra	ABHD16A	O95870	RNF5	Homo sapiens	Q99942	Y2H Array	25416956
Intra	ABHD16A	O95870	POLE	Homo sapiens	Q07864	Validated Y2H	32296183
Intra	ABHD16A	O95870	POLE	Homo sapiens	Q07864	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	POLE	Homo sapiens	Q07864	Y2H Array	32296183
Intra	ABHD16A	O95870	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	ABHD16A	O95870	TMEM147	Homo sapiens	Q9BVK8	Y2H	14667819
Intra	ABHD16A	O95870	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	ABHD16A	O95870	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	ABHD16A	O95870	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	GORAB	Homo sapiens	Q5T7V8	Validated Y2H	32296183
Intra	ABHD16A	O95870	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	ABHD16A	O95870	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	ABHD16A	O95870	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	ABHD16A	O95870	SLC10A1	Homo sapiens	Q14973	Validated Y2H	32296183
Intra	ABHD16A	O95870	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	ABHD16A	O95870	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	LTA	Homo sapiens	P01374	Validated Y2H	32296183
Intra	ABHD16A	O95870	TM4SF19	Homo sapiens	Q96DZ7	Y2H Array	32296183
Intra	ABHD16A	O95870	TM4SF19	Homo sapiens	Q96DZ7	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	TM4SF19	Homo sapiens	Q96DZ7	Validated Y2H	32296183
Intra	ABHD16A	O95870	TMEM65	Homo sapiens	Q6PI78	Validated Y2H	32296183
Intra	ABHD16A	O95870	CIDEB	Homo sapiens	Q9UHD4	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183
Intra	ABHD16A	O95870	CIDEB	Homo sapiens	Q9UHD4	Y2H Array	32296183
Intra	ABHD16A	O95870	TMEM139	Homo sapiens	Q8IV31	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	TMEM139	Homo sapiens	Q8IV31	Validated Y2H	32296183
Intra	ABHD16A	O95870	TMEM139	Homo sapiens	Q8IV31	Y2H Array	32296183
Intra	ABHD16A	O95870	DTX2	Homo sapiens	Q86UW9	Y2H Prey Pooling	25416956
Intra	ABHD16A	O95870	DTX2	Homo sapiens	Q86UW9	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	DTX2	Homo sapiens	Q86UW9	Validated Y2H	32296183
Intra	ABHD16A	O95870	DTX2	Homo sapiens	Q86UW9	Y2H Array	32296183
Intra	ABHD16A	O95870	GJA5	Homo sapiens	P36382	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	GJA5	Homo sapiens	P36382	Validated Y2H	32296183
Intra	ABHD16A	O95870	GJA5	Homo sapiens	P36382	Y2H Array	32296183
Intra	ABHD16A	O95870	GYPC	Homo sapiens	P04921	Validated Y2H	32296183
Intra	ABHD16A	O95870	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	ABHD16A	O95870	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	ABHD16A	O95870	IFITM3	Homo sapiens	Q01628	Validated Y2H	32296183
Intra	ABHD16A	O95870	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	ABHD16A	O95870	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	ABHD16A	O95870	SLC30A2	Homo sapiens	Q9BRI3	Y2H Prey Pooling	32296183
Intra	ABHD16A	O95870	SLC30A2	Homo sapiens	Q9BRI3	Y2H Array	32296183
Intra	ABHD16A	O95870	SLC30A2	Homo sapiens	Q9BRI3	Validated Y2H	32296183
Intra	ABHD16A	O95870	STX1B	Homo sapiens	P61266	Validated Y2H	32296183
Intra	ABHD16A	O95870	FDPS	Homo sapiens	P14324	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

ABHD16A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82508	BAT5 Antibody (YA2253)	WB	Human, Rat

Related Diseases

Diseases

Alias

Spastic Paraplegia 86, Autosomal Recessive

SPG86	Hereditary Spastic Paraplegia 86
Spastic Paraplegia 86 Autosomal Recessive	Doid:0112342

Complex Hereditary Spastic Paraplegia

Complex Hsp	Complex Spg
Complex Familial Spastic Paraplegia	Complicated Hsp
Complicated Spg	Complicated Familial Spastic Paraplegia
Complicated Hereditary Spastic Paraplegia

Autosomal Recessive Complex Spastic Paraplegia

Autosomal Recessive Complex Hsp	Autosomal Recessive Complex Spg
Autosomal Recessive Complicated Hsp	Autosomal Recessive Complicated Spg
Autosomal Recessive Complicated Spastic Paraplegia

Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract

Pharc Syndrome	PHARC
Polyneyropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract	Polyneuropathy-Hearing Loss-Ataxia-Retinitis Pigmentosa-Cataract Syndrome
Peripheral Neuropathy, Fiskerstrand Type	Polyneuropathy-Deafness-Ataxia-Retinitis Pigmentosa-Cataract Syndrome
Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, Cataract

Oliver-Mcfarlane Syndrome

Trichomegaly-Retina Pigmentary Degeneration-Dwarfism Syndrome	OMCS
Long Eyelashes-Intellectual Disability Syndrome	Trichomegaly With Mental Retardation, Dwarfism, And Pigmentary Degeneration Of Retina
Eyelashes, Long, With Mental Retardation	Eyelashes Long Mental Retardation
Trichomegaly With Intellectual Disability, Dwarfism And Pigmentary Degeneration	Trichomegaly With Intellectual Disability, Dwarfism And Pigmentary Degeneration Of Retina
Eyelashes, Long With Intellectual Disability	Oliver Mcfarlane Syndrome
Congenital Trichomegaly, Pigmentary Retinal Degeneration, And Short Stature	Trichomegaly, Retina Pigmentary Degeneration, Dwarfism
Trichomegaly Retina Pigmentary Degeneration Dwarfism

Short-Rib Thoracic Dysplasia 6 With Or Without Polydactyly

Majewski Syndrome	SRTD6
Srps2a	Short Rib-Polydactyly Syndrome, Majewski Type
Polydactyly With Neonatal Chondrodystrophy, Type Ii	Short Rib-Polydactyly Syndrome Type Iia
Short Rib-Polydactyly Syndrome Type 2	Short Rib-Polydactyly Syndrome Type Ii
Short Rib-Polydactyly Syndrome, Type Ii	Srps, Type Ii
Short Rib-Polydactyly Syndrome, Type Iia	Polydactyly With Neonatal Chondrodystrophy Type 2
Srps Type 2	Short Rib-Polydactyly Syndrome Majewski Type
Polydactyly With Neonatal Chondrodystrophy Type Ii	Short Rib-Polydactyly Syndrome 2a
Srps Type Ii

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120299	KC01	Inhibitor	≥99.0%	Unkown
HY-121892	(Z)-KC02		/	Unkown
HY-RS00090	ABHD16A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ABHD16A	VGNC	VGNC:37464
Felis catus	ABHD16A	VGNC	VGNC:59481
Bos taurus	ABHD16A	VGNC	VGNC:25495
Macaca mulatta	ABHD16A	VGNC	VGNC:69393
Mus musculus	ABHD16A	MGD	MGI:99476
Rattus norvegicus	ABHD16A	RGD	RGD:1303164

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