LSM4 - LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

Homo sapiens

Also known as GRP; YER112W

Gene ID: 25804 | Gene type: protein coding

About LSM4

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,306,236-18,323,076 (from NCBI)

This gene has 6 transcripts (splice variants), 196 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 22.8), colon (RPKM 19.7) and 25 other tissues.

Summary

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

LSM4 Products(2)

mRNA	Protein	Name
NM_001252129.2	NP_001239058.1	U6 snRNA-associated Sm-like protein LSm4 isoform 2
NM_012321.5	NP_036453.1	U6 snRNA-associated Sm-like protein LSm4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PH domain binding	IDA IDA: Inferred from direct assay	15905169	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15231747	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Lsm2-8 complex	IDA IDA: Inferred from direct assay	10523320	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: Inferred from direct assay	26912367	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: Inferred from physical interaction	30975767	GOA
located in cytosol	IDA IDA: Inferred from direct assay	15905169	GOA
located in membrane	IDA IDA: Inferred from direct assay	15905169	GOA
located in nucleus	IDA IDA: Inferred from direct assay	26912367	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	15905169	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LSM4 Protein Structure

LSM

0
100
139 a.a.

Protein Preferred Names

Protein Names

U6 snRNA-associated Sm-like protein LSm4

LSM4 U6 small nuclear RNA and mRNA degradation associated

Recombinant LSM4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70944	LSM4 Protein, Human (His)	Q9Y4Z0 (M1-Q139)	≥95%

Related Diseases

Diseases

Alias

Trombiculiasis

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Tick Infestation

Tick Infestations

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07859	LSM4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	LSM4	VGNC	VGNC:31056
Canis familiaris	LSM4	VGNC	VGNC:42844
Felis catus	LSM4	VGNC	VGNC:102631
Rattus norvegicus	LSM4	RGD	RGD:1306808
Macaca mulatta	LSM4	VGNC	VGNC:74304
Mus musculus	LSM4	MGD	MGI:1354692
Others	LSM4	NCBI

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