2. Gene
  3. LSM7 - LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

LSM7 - LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as YNL147W

Gene ID: 51690 | Gene type: protein coding

About LSM7

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,321,521-2,328,586 (from NCBI)

This gene has 7 transcripts (splice variants), 195 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 29.6), bone marrow (RPKM 20.9) and 25 other tissues.

Summary

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

LSM7 Products(1)

mRNA Protein Name
NM_016199.3 NP_057283.1 U6 snRNA-associated Sm-like protein LSm7
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12165861 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Lsm2-8 complex IDA
IDA: Inferred from direct assay
10523320 GOA
part of U2-type precatalytic spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
part of U4/U6 x U5 tri-snRNP complex IDA
IDA: Inferred from direct assay
26912367 GOA
part of U4/U6 x U5 tri-snRNP complex IPI
IPI: Inferred from physical interaction
30975767 GOA
located in nucleus IDA
IDA: Inferred from direct assay
26912367 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LSM7 Protein Structure

LSM

LSM: LSM domain (14 - 86)

  • 0
  • 103 a.a.
Protein Preferred Names Protein Names

U6 snRNA-associated Sm-like protein LSm7

LSM7 U6 small nuclear RNA and mRNA degradation associated

LSM7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LSM7 Q9UK45 LSM2 Homo sapiens Q9Y333
Y2H Array
32296183
Intra
LSM7 Q9UK45 LSM2 Homo sapiens Q9Y333
Anti Tag CoIP
33961781
Intra
LSM7 Q9UK45 LSM2 Homo sapiens Q9Y333
Y2H Prey Pooling
32296183
Intra
LSM7 Q9UK45 LSM2 Homo sapiens Q9Y333
Validated Y2H
32296183
Intra
LSM7 Q9UK45 LSM2 Homo sapiens Q9Y333
Y2H
15231747
Intra
LSM7 Q9UK45 LSM8 Homo sapiens O95777
Anti Tag CoIP
33961781
Intra
LSM7 Q9UK45 LSM3 Homo sapiens P62310
Y2H
15231747
Intra
LSM7 Q9UK45 SNRPF Homo sapiens P62306
Y2H
22365833
Intra
LSM7 Q9UK45 LSM4 Homo sapiens Q9Y4Z0
Y2H
15231747
Intra
LSM7 Q9UK45 LSM4 Homo sapiens Q9Y4Z0
Validated Y2H
32296183
Intra
LSM7 Q9UK45 SNRPD3 Homo sapiens P62318
Y2H
15231747
Intra
LSM7 Q9UK45 LSM5 Homo sapiens Q9Y4Y9
Anti Tag CoIP
33961781
Intra
LSM7 Q9UK45 LSM5 Homo sapiens Q9Y4Y9
Validated Y2H
32296183
Intra
LSM7 Q9UK45 LSM5 Homo sapiens Q9Y4Y9
Y2H Array
25416956
Intra
LSM7 Q9UK45 LSM5 Homo sapiens Q9Y4Y9
Y2H
15231747
Intra
LSM7 Q9UK45 LSM6 Homo sapiens P62312
Y2H
22365833
Intra
LSM7 Q9UK45 LSM6 Homo sapiens P62312
Y2H
15231747
Intra
LSM7 Q9UK45 TACC1 Homo sapiens O75410-1
Anti Bait CoIP
12165861
Intra
LSM7 Q9UK45 TACC1 Homo sapiens O75410-1
Y2H
12165861
Intra
LSM7 Q9UK45 TCL1B Homo sapiens O95988
Y2H Array
32296183
Intra
LSM7 Q9UK45 TCL1B Homo sapiens O95988
Y2H Prey Pooling
32296183
Intra
LSM7 Q9UK45 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
LSM7 Q9UK45 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
25416956
Intra
LSM7 Q9UK45 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Leukodystrophy

Leukodystrophies
Hypomyelinating Leukodystrophy

Hld

Leukodystrophy, Hypomyelinating
Spermatogenic Failure 5

Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa

Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna

SPGF5

Macrocephalic Sperm Head Syndrome

Male Infertility Due To Macrozoospermia

Infertility Associated With Multitailed Spermatozoa And Excessive Dna

Macrozoospermia

Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa

Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid

Large-Headed Multiflagellar Polyploid Spermatozoa

Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa
Spinal Muscular Atrophy

Sma

5q Sma

Proximal Sma

Sma-Associated Sma

Spinal Amyotrophies

Spinal Amyotrophy

Spinal Muscle Degeneration

Spinal Muscle Wasting

Muscular Atrophy Spinal

Atrophy, Muscular, Spinal

Hereditary Motor Neuronopathy

Progressive Muscular Atrophy

Sma - [Spinal Muscular Atrophy]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07862 LSM7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LSM7 VGNC VGNC:42846
Felis catus LSM7 VGNC VGNC:63325
Mus musculus LSM7 MGD MGI:1913344
Bos taurus LSM7 VGNC VGNC:31059
Rattus norvegicus LSM7 RGD RGD:1305354