2. Gene
  3. LSM8 - LSM8 homolog, U6 small nuclear RNA associated Gene

LSM8 - LSM8 homolog, U6 small nuclear RNA associated Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NAA38

Gene ID: 51691 | Gene type: protein coding

About LSM8

Cytogenetic location: 7q31.31 Genomic coordinates (GRCh38): 7:118,184,164-118,204,035 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 1.1), spleen (RPKM 0.9) and 25 other tissues.

Summary

This gene encodes a member of the like-Sm family of proteins. The encoded protein consists of a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. This protein partners with six paralogs to form a heteroheptameric ring which transiently binds U6 small nuclear RNAs and is involved in the general maturation of RNA in the nucleus. [provided by RefSeq, Jan 2010]

LSM8 Products(1)

mRNA Protein Name
NM_016200.5 NP_057284.1 LSM8 homolog, U6 small nuclear RNA associated
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14667819 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Lsm2-8 complex IDA
IDA: Inferred from direct assay
10523320 GOA
part of U2-type precatalytic spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
part of U4/U6 x U5 tri-snRNP complex IDA
IDA: Inferred from direct assay
26912367 GOA
part of U4/U6 x U5 tri-snRNP complex IPI
IPI: Inferred from physical interaction
30975767 GOA
located in nucleus IDA
IDA: Inferred from direct assay
26912367 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LSM8 Protein Structure

LSM

LSM: LSM domain (5 - 71)

  • 0
  • 96 a.a.
Protein Preferred Names Protein Names

LSM8 homolog, U6 small nuclear RNA associated

LSM8 U6 small nuclear RNA associated

LSM8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LSM8 O95777 LSM2 Homo sapiens Q9Y333
Y2H
15231747
Intra
LSM8 O95777 LSM3 Homo sapiens P62310
Y2H
15231747
Intra
LSM8 O95777 LSM7 Homo sapiens Q9UK45
Y2H
15231747
Intra
LSM8 O95777 LSM4 Homo sapiens Q9Y4Z0
Y2H
15231747
Intra
LSM8 O95777 TARDBP Homo sapiens Q13148
Validated Y2H
32814053
Intra
LSM8 O95777 TARDBP Homo sapiens Q13148
Y2H Pooling
32814053
Intra
LSM8 O95777 TARDBP Homo sapiens Q13148
Y2H Array
32814053
Intra
LSM8 O95777 LSM6 Homo sapiens P62312
Y2H
15231747
Intra
LSM8 O95777 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
LSM8 O95777 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
LSM8 O95777 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
LSM8 O95777 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
LSM8 O95777 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
LSM8 O95777 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
LSM8 O95777 SNCA Homo sapiens P37840
Validated Y2H
32814053
Intra
LSM8 O95777 SNCA Homo sapiens P37840
Y2H Array
32814053
Intra
LSM8 O95777 SNCA Homo sapiens P37840
Y2H Pooling
32814053
Intra
LSM8 O95777 SOD1 Homo sapiens P00441
Validated Y2H
32814053
Intra
LSM8 O95777 SOD1 Homo sapiens P00441
Y2H Pooling
32814053
Intra
LSM8 O95777 SOD1 Homo sapiens P00441
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Night Blindness, Congenital Stationary, Autosomal Dominant 1

Congenital Stationary Night Blindness Autosomal Dominant 1

CSNBAD1

Rhodopsin-Related Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary, Rhodopsin-Related

Blindness, Night, Stationary, Congenital, Autosomal Dominant, Type 1
Poikiloderma With Neutropenia

Poikiloderma With Neutropenia, Clericuzio Type

PN

Clericuzio Type Poikiloderma With Neutropenia

Poikiloderma With Neutropenia, Clericuzio-Type

Clericuzio-Type Poikiloderma With Neutropenia

Poikiloderma With Neutropenia Clericuzio Type

Immune-Deficient Poikiloderma

Clericuzio-Type Poikiloderma Neutropenia Syndrome

Poikiloderma With Neutropenia Clericuzio-Type

Poikiloderma, With Neutropenia
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07863 LSM8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LSM8 VGNC VGNC:80618
Macaca mulatta LSM8 VGNC VGNC:81636
Bos taurus LSM8 VGNC VGNC:31060
Mus musculus LSM8 MGD MGI:1923772
Canis familiaris LSM8 VGNC VGNC:49756
Rattus norvegicus LSM8 RGD RGD:1308442