ARIH1 - ariadne RBR E3 ubiquitin protein ligase 1 Gene

Homo sapiens

Also known as ARI; HARI; HHARI; UBCH7BP

Gene ID: 25820 | Gene type: protein coding

About ARIH1

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:72,474,330-72,602,987 (from NCBI)

This gene has 10 transcripts (splice variants), 231 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 22.0), thyroid (RPKM 13.4) and 25 other tissues.

Summary

Enables Enzyme binding activity; ubiquitin-protein transferase activity; and zinc ion binding activity. Involved in protein ubiquitination. Located in Lewy body; cytoplasm; and nuclear body. Colocalizes with cullin-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

ARIH1 Products(1)

mRNA	Protein	Name
NM_005744.5	NP_005735.2	E3 ubiquitin-protein ligase ARIH1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10521492	GOA
enables ubiquitin conjugating enzyme binding	IPI IPI: Inferred from physical interaction	23707686	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	11278816	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	14623119	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	15236971	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	14623119	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
NOT part of Cul2-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	27565346	GOA
part of Cul2-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	24076655	GOA
part of Cul3-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	24076655	GOA
part of Cul4A-RING E3 ubiquitin ligase complex	IDA IDA: Inferred from direct assay	24076655	GOA
located in Lewy body	IDA IDA: Inferred from direct assay	21590270	GOA
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	24076655	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11278816	GOA
located in nuclear body	IDA IDA: Inferred from direct assay	23059369	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARIH1 Protein Structure

zf-C3HC4_2

IBR

0
100
200
300
400
500
557 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase ARIH1

ARI-1

ARIH1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARIH1	Q9Y4X5	UBE2L3	Homo sapiens	P68036-1	ITC	23707686
Intra	ARIH1	Q9Y4X5	UBE2L3	Homo sapiens	P68036-1	Pull Down	21532592
Intra	ARIH1	Q9Y4X5	UBE2L3	Homo sapiens	P68036-1	GMS	23707686
Intra	ARIH1	Q9Y4X5	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	33961781
Intra	ARIH1	Q9Y4X5	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	24076655
Intra	ARIH1	Q9Y4X5	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	28514442
Intra	ARIH1	Q9Y4X5	UBE2L3	Homo sapiens	P68036	Anti Tag CoIP	24076655
Intra	ARIH1	Q9Y4X5	UBE2L3	Homo sapiens	P68036	Anti Tag CoIP	33961781
Intra	ARIH1	Q9Y4X5	UBE2L3	Homo sapiens	P68036	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cerebrovascular Disease

Cerebrovascular Disorder	Cerebrovascular Accident
Cerebrovascular Disorders	Cva
Stroke

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Familial Thoracic Aortic Aneurysm
Congenital Aneurysm Of Ascending Aorta	Familial Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00975	ARIH1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-164476	ES-072		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ARIH1	MGD	MGI:1344363
Felis catus	ARIH1	VGNC	VGNC:68178
Macaca mulatta	ARIH1	VGNC	VGNC:84308
Rattus norvegicus	ARIH1	RGD	RGD:1308131
Bos taurus	ARIH1	VGNC	VGNC:26133
Canis familiaris	ARIH1	VGNC	VGNC:38102

Name
Email *

	Sorry, but the email address you supplied was invalid.