METTL7A - methyltransferase like 7A Gene

Homo sapiens

Also known as AAMB; AAM-B

Gene ID: 25840 | Gene type: protein coding

About METTL7A

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:50,925,015-50,932,508 (from NCBI)

This gene has 5 transcripts (splice variants), 311 orthologues and 4 paralogues. Broad expression in liver (RPKM 132.2), thyroid (RPKM 109.3) and 24 other tissues.

Summary

Predicted to enable methyltransferase activity. Predicted to be involved in methylation. Located in lipid droplet. [provided by Alliance of Genome Resources, Apr 2022]

METTL7A Products(1)

mRNA	Protein	Name
NM_014033.4	NP_054752.3	putative methyltransferase-like protein 7A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA methyltransferase activity	IDA IDA: Inferred from direct assay	34980213	GOA
enables mRNA m(6)A methyltransferase activity	IMP IMP: Inferred from mutant phenotype	34226523	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA
enables thiol S-methyltransferase activity	IDA IDA: Inferred from direct assay	37137720	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in lncRNA processing	IMP IMP: Inferred from mutant phenotype	34980213	GOA
involved in odontogenesis	IMP IMP: Inferred from mutant phenotype	34790668	GOA
involved in osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	34226523	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19773358	GOA
located in lipid droplet	IDA IDA: Inferred from direct assay	18477614	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL7A Protein Structure

Methyltransf_11

0
100
200
244 a.a.

Protein Preferred Names

Protein Names

putative methyltransferase-like protein 7A

methyltransferase-like protein 7A

METTL7A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TMT1A	Q9H8H3	NDUFS3	Homo sapiens	O75489	Y2H Array	32814053
Intra	TMT1A	Q9H8H3	NDUFS3	Homo sapiens	O75489	Y2H Pooling	32814053
Intra	TMT1A	Q9H8H3	NDUFS3	Homo sapiens	O75489	Validated Y2H	32814053
Intra	TMT1A	Q9H8H3	PRKCA	Homo sapiens	P17252	Validated Y2H	32814053
Intra	TMT1A	Q9H8H3	PRKCA	Homo sapiens	P17252	Y2H Pooling	32814053
Intra	TMT1A	Q9H8H3	PRKCA	Homo sapiens	P17252	Y2H Array	32814053
Intra	TMT1A	Q9H8H3	PPIA	Homo sapiens	P62937-2	Y2H Pooling	32814053
Intra	TMT1A	Q9H8H3	PPIA	Homo sapiens	P62937-2	Validated Y2H	32814053
Intra	TMT1A	Q9H8H3	PPIA	Homo sapiens	P62937-2	Y2H Array	32814053
Intra	TMT1A	Q9H8H3	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	TMT1A	Q9H8H3	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	TMT1A	Q9H8H3	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	TMT1A	Q9H8H3	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	TMT1A	Q9H8H3	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	TMT1A	Q9H8H3	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	TMT1A	Q9H8H3	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	TMT1A	Q9H8H3	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	TMT1A	Q9H8H3	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	TMT1A	Q9H8H3	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	TMT1A	Q9H8H3	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	TMT1A	Q9H8H3	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	TMT1A	Q9H8H3	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	TMT1A	Q9H8H3	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	TMT1A	Q9H8H3	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Malignant Otitis Externa

Necrotising Otitis Externa

Pseudomonas Aeruginosa Osteomyelitis Of The Temporal Bone

Pulmonary Aspergilloma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08368	METTL7A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	METTL7A	VGNC	VGNC:74567
Felis catus	METTL7A	VGNC	VGNC:97506
Rattus norvegicus	METTL7A	RGD	RGD:1308407
Canis familiaris	METTL7A	VGNC	VGNC:43180

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