MOB4 - MOB family member 4, phocein Gene

Homo sapiens

Also known as 2C4D; MOB1; MOB3; PHOCN; PREI3; CGI-95; MOBKL3

Gene ID: 25843 | Gene type: protein coding

About MOB4

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:197,515,554-197,553,699 (from NCBI)

This gene has 8 transcripts (splice variants), 234 orthologues and 6 paralogues. Ubiquitous expression in adrenal (RPKM 20.9), esophagus (RPKM 14.5) and 25 other tissues.

Summary

This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HSPE1.[provided by RefSeq, Feb 2011]

MOB4 Products(4)

mRNA	Protein	Name
NM_001100819.3	NP_001094289.1	MOB-like protein phocein isoform 3
NM_001204094.1	NP_001191023.1	MOB-like protein phocein isoform 2
NM_015387.5	NP_056202.2	MOB-like protein phocein isoform 1
NM_199482.4	NP_955776.1	MOB-like protein phocein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18782753	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	33633399	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of hippo signaling	IDA IDA: Inferred from direct assay	33633399	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of FAR/SIN/STRIPAK complex	IDA IDA: Inferred from direct assay	18782753	GOA
located in Golgi apparatus	IDA IDA: Inferred from direct assay	11251078	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOB4 Protein Structure

Mob1_phocein

0
100
200
225 a.a.

Protein Preferred Names

Protein Names

MOB-like protein phocein

MOB1, Mps One Binder kinase activator-like 3

Recombinant MOB4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70940	MOB4 Protein, Human (His)	Q9Y3A3 (M1-A225)	≥95%

Related Diseases

Diseases

Alias

Cerebral Cavernous Malformations 3

Cerebral Cavernous Malformation 3	CCM3
Cerebral Cavernous Malformations-3	Cavernous Angiomatous Malformations
Cavernous Hemangioma Of The Brain	Cerebral Capillary Malformations
Cerebral Cavernoma	Familial Cavernous Angioma
Cerebral Cavernous Malformations, Type 3

Osteogenesis Imperfecta, Type X

Osteogenesis Imperfecta Type 10	OI10
Osteogenesis Imperfecta Type X	Oi, Type X
Osteogenesis Imperfecta 10	Oi Type X
Oi-X

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08577	MOB4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MOB4	RGD	RGD:620183
Mus musculus	MOB4	MGD	MGI:104899

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