VIRMA - vir like m6A methyltransferase associated Gene

Homo sapiens

Also known as MSTP054; fSAP121; KIAA1429

Gene ID: 25962 | Gene type: protein coding

About VIRMA

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:94,487,689-94,553,469 (from NCBI)

This gene has 9 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in testis (RPKM 11.6), ovary (RPKM 8.4) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in mRNA alternative polyadenylation and mRNA methylation. Located in cytosol and nuclear speck. Colocalizes with RNA N6-methyladenosine methyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

VIRMA Products(2)

mRNA	Protein	Name
NM_015496.5	NP_056311.2	protein virilizer homolog isoform 1
NM_183009.3	NP_892121.1	protein virilizer homolog isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15161933	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA processing	IDA IDA: Inferred from direct assay	29507755	GOA
involved in mRNA processing	IMP IMP: Inferred from mutant phenotype	24981863	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA N6-methyladenosine methyltransferase complex	IDA IDA: Inferred from direct assay	24981863	GOA
part of RNA N6-methyladenosine methyltransferase complex	IPI IPI: Inferred from physical interaction	29507755	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	24100041	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	24100041	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein virilizer homolog

functional spliceosome-associated protein 121

Related Diseases

Diseases

Alias

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15657	VIRMA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	VIRMA	MGD	MGI:1913435
Macaca mulatta	VIRMA	VGNC	VGNC:79436
Canis familiaris	VIRMA	VGNC	VGNC:48267
Bos taurus	VIRMA	VGNC	VGNC:36801
Felis catus	VIRMA	VGNC	VGNC:66947
Rattus norvegicus	VIRMA	RGD	RGD:1559904

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