2. Gene
  3. TES - testin LIM domain protein Gene

TES - testin LIM domain protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TESS; TESS-2

Gene ID: 26136 | Gene type: protein coding

About TES

Cytogenetic location: 7q31.2 Genomic coordinates (GRCh38): 7:116,210,539-116,258,783 (from NCBI)

This gene has 11 transcripts (splice variants), 223 orthologues and 3 paralogues. Ubiquitous expression in urinary bladder (RPKM 42.6), thyroid (RPKM 41.1) and 23 other tissues.

Summary

Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin Cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Mar 2011]

TES Products(2)

mRNA Protein Name
NM_015641.4 NP_056456.1 testin isoform 1
NM_152829.3 NP_690042.1 testin isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21278383 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
21278383 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11420696 GOA
Cellular Component GO Annotation Evidence Reference Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
21278383 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TES Protein Structure

PET

PET: PET Domain (92 - 195)

LIM

LIM: LIM domain (236 - 296)

LIM

LIM: LIM domain (301 - 357)

  • 0
  • 100
  • 200
  • 300
  • 421 a.a.
Protein Preferred Names Protein Names

testin

testis derived transcript (3 LIM domains)

Related Diseases

Diseases Alias
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (18)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1532 Anabasine Agonist 99.87% Unkown
HY-111365 TES-1025 Inhibitor 98.12% Unkown
HY-112619 TES-991 Inhibitor 99.65% Unkown
HY-23430 TES ≥98.0% Unkown
HY-151598 Pks13-TE inhibitor 2 Inhibitor / Unkown
HY-151599 Pks13-TE inhibitor 3 Inhibitor / Unkown
HY-156138A CB-TE2A tetrahydrochloride / Unkown
HY-159518 ROS inducer 4 / Unkown
HY-161046 PLK1-IN-8 Inhibitor / Unkown
HY-23430A TES sodium ≥98.0% Unkown
HY-23430S TES-d15 / Unkown
HY-D1392 Ag2Te QDs / Unkown
HY-P3571 [Ala2] Endothelin-3, human / Unkown
HY-RS14378 TES Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W014928 Anabasine hydrochloride Agonist / Unkown
HY-W022973 Trinexapac-ethyl / Unkown
HY-118147 ML356 Inhibitor / Unkown
HY-155460 Pks13-TE inhibitor 4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TES MGD MGI:105081
Rattus norvegicus TES RGD RGD:1566346
Felis catus TES VGNC VGNC:66087
Bos taurus TES VGNC VGNC:35752
Macaca mulatta TES VGNC VGNC:78383
Canis familiaris TES VGNC VGNC:47256
Macaca fascicularis TES NCBI NCBI:102120966
Canis lupus familiaris TES NCBI
Others TES NCBI