FBXO5 - F-box protein 5 Gene

Homo sapiens

Also known as EMI1; FBX5; Fbxo31

Gene ID: 26271 | Gene type: protein coding

About FBXO5

Cytogenetic location: 6q25.2 Genomic coordinates (GRCh38): 6:152,970,535-152,983,579 (from NCBI)

This gene has 3 transcripts (splice variants), 195 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 14.0), lymph node (RPKM 6.9) and 22 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008]

FBXO5 Products(2)

mRNA	Protein	Name
NM_001142522.3	NP_001135994.1	F-box only protein 5 isoform b
NM_012177.5	NP_036309.1	F-box only protein 5 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables anaphase-promoting complex binding	IDA IDA: Inferred from direct assay	16921029	GOA
enables molecular function inhibitor activity	IDA IDA: Inferred from direct assay	23708605	GOA
enables molecular function inhibitor activity	IMP IMP: Inferred from mutant phenotype	23708605	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11988738	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15148369	GOA
enables ubiquitin ligase inhibitor activity	IDA IDA: Inferred from direct assay	15148369	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	17875940	GOA
involved in negative regulation of DNA endoreduplication	IMP IMP: Inferred from mutant phenotype	17875940	GOA
involved in negative regulation of cellular senescence	IMP IMP: Inferred from mutant phenotype	17875940	GOA
involved in negative regulation of mitotic metaphase/anaphase transition	IDA IDA: Inferred from direct assay	11988738	GOA
involved in negative regulation of ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	11988738	GOA
involved in negative regulation of ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	23708605	GOA
involved in negative regulation of ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	23708001	GOA
involved in positive regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	17485488	GOA
involved in positive regulation of biomineral tissue development	IMP IMP: Inferred from mutant phenotype	29850565	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17234884	GOA
involved in positive regulation of mesenchymal stem cell migration	IMP IMP: Inferred from mutant phenotype	29850565	GOA
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	29850565	GOA
involved in regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	17234884	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11988738	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11988738	GOA
located in spindle	IDA IDA: Inferred from direct assay	15469984	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO5 Protein Structure

F-box

0
100
200
300
400
447 a.a.

Protein Preferred Names

Protein Names

F-box only protein 5

F-box protein Fbx5

Related Diseases

Diseases

Alias

Aleutian Mink Disease

Aleutian Disease

Arthrogryposis Multiplex Congenita 2, Neurogenic Type

Arthrogryposis Multiplex Congenita, Neurogenic Type	Amcn
Arthrogryposis Multiplex Congenita Neurogenic Type	AMC2
Amc, Neurogenic Type	Neurogenic-Type Arthrogryposis Multiplex Congenita-2
Amc Neurogenic Type	Neurogenic Type Of Amc
Neurogenic Arthrogryposis Multiplex Congenita	Arthrogryposis Multiplex Congenita, Neurogenic

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04811	FBXO5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FBXO5	VGNC	VGNC:62196
Canis familiaris	FBXO5	VGNC	VGNC:40787
Mus musculus	FBXO5	MGD	MGI:1914391
Macaca mulatta	FBXO5	VGNC	VGNC:72489
Rattus norvegicus	FBXO5	RGD	RGD:1309405
Bos taurus	FBXO5	VGNC	VGNC:28917

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