2. Gene
  3. CDC27 - cell division cycle 27 Gene

CDC27 - cell division cycle 27 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as APC3; HNUC; NUC2; H-NUC; ANAPC3; CDC27Hs; D0S1430E; D17S978E

Gene ID: 996 | Gene type: protein coding

About CDC27

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,117,703-47,189,295 (from NCBI)

This gene has 19 transcripts (splice variants), 205 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 20.3), testis (RPKM 11.6) and 25 other tissues.

Summary

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]

CDC27 Products(9)

mRNA Protein Name
NM_001114091.4 NP_001107563.1 cell division cycle protein 27 homolog isoform 1
NM_001256.6 NP_001247.3 cell division cycle protein 27 homolog isoform 2
NM_001293089.3 NP_001280018.1 cell division cycle protein 27 homolog isoform 3
NM_001293091.3 NP_001280020.1 cell division cycle protein 27 homolog isoform 4
NM_001353035.2 NP_001339964.1 cell division cycle protein 27 homolog isoform 5
NM_001353047.2 NP_001339976.1 cell division cycle protein 27 homolog isoform 6
NM_001353049.2 NP_001339978.1 cell division cycle protein 27 homolog isoform 7
NM_001353050.2 NP_001339979.1 cell division cycle protein 27 homolog isoform 8
NM_001353051.2 NP_001339980.1 cell division cycle protein 27 homolog isoform 9
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10548110 GOA
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
21241890 GOA
Biological Process GO Annotation Evidence Reference Source
involved in anaphase-promoting complex-dependent catabolic process IDA
IDA: Inferred from direct assay
29033132 GOA
acts upstream of or within metaphase/anaphase transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
7736578 GOA
involved in protein K11-linked ubiquitination IDA
IDA: Inferred from direct assay
18485873 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
29033132 GOA
involved in protein branched polyubiquitination IDA
IDA: Inferred from direct assay
29033132 GOA
Cellular Component GO Annotation Evidence Reference Source
part of anaphase-promoting complex IDA
IDA: Inferred from direct assay
16364912 GOA
part of anaphase-promoting complex IPI
IPI: Inferred from physical interaction
27120157 GOA
located in centrosome IDA
IDA: Inferred from direct assay
7736578 GOA
located in mitotic spindle IDA
IDA: Inferred from direct assay
7736578 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18445686 GOA
located in spindle IDA
IDA: Inferred from direct assay
18445686 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC27 Protein Structure

ANAPC3

ANAPC3: Anaphase-promoting complex, cyclosome, subunit 3 (17 - 93)

TPR_1

TPR_1: Tetratricopeptide repeat (118 - 146)

TPR_11

TPR_11: TPR repeat (600 - 666)

TPR_1

TPR_1: Tetratricopeptide repeat (671 - 702)

TPR_11

TPR_11: TPR repeat (703 - 768)

  • 0
  • 200
  • 400
  • 600
  • 824 a.a.
Protein Preferred Names Protein Names

cell division cycle protein 27 homolog

D0S1430E, D17S978E

Related Diseases

Diseases Alias
Glandular Tularemia
Pyomyositis

Tropical Pyomyositis

Myositis Tropicans

Myositis Purulenta Tropica

Pm

Suppurative Myositis

Purulent Myositis
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02295 CDC27 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CDC27 VGNC VGNC:60653
Mus musculus CDC27 MGD MGI:102685
Rattus norvegicus CDC27 RGD RGD:1304921
Bos taurus CDC27 VGNC VGNC:50040
Canis familiaris CDC27 VGNC VGNC:53202
Macaca mulatta CDC27 VGNC VGNC:70797