MYCBP - MYC binding protein Gene

Homo sapiens

Also known as AMY-1

Gene ID: 26292 | Gene type: protein coding

About MYCBP

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:38,862,490-38,873,378 (from NCBI)

This gene has 4 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in testis (RPKM 11.1), colon (RPKM 10.6) and 25 other tissues.

Summary

The protein encoded by this gene binds to the N-terminus of the oncogenic protein c-Myc, enhancing the ability of c-Myc to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with c-Myc. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the Other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]

MYCBP Products(1)

mRNA	Protein	Name
NM_012333.5	NP_036465.2	C-Myc-binding protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12151104	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	9797456	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9797456	GOA
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	12151104	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9797456	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9797456	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

C-Myc-binding protein

associate of myc-1

MYCBP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MYCBP	Q99417	ARFGEF1	Homo sapiens	Q9Y6D6	Anti Tag CoIP	33961781
Intra	MYCBP	Q99417	ARFGEF1	Homo sapiens	Q9Y6D6	Anti Tag CoIP	16866877
Intra	MYCBP	Q99417	ARFGEF1	Homo sapiens	Q9Y6D6	Y2H	16866877
Intra	MYCBP	Q99417	AKAP8	Homo sapiens	O43823	Anti Tag CoIP	33961781
Intra	MYCBP	Q99417	MYCBPAP	Homo sapiens	Q8TBZ2	Anti Tag CoIP	12151104
Intra	MYCBP	Q99417	CFAP91	Homo sapiens	Q7Z4T9-3	Confocal	12223483
Intra	MYCBP	Q99417	CFAP91	Homo sapiens	Q7Z4T9-3	Pull Down	12223483
Intra	MYCBP	Q99417	AKAP1	Homo sapiens	Q92667-2	Anti Tag CoIP	12223483
Intra	MYCBP	Q99417	ARFGEF2	Homo sapiens	Q9Y6D5	Anti Tag CoIP	33961781
Intra	MYCBP	Q99417	ARFGEF2	Homo sapiens	Q9Y6D5	Imaging	16866877
Intra	MYCBP	Q99417	ARFGEF2	Homo sapiens	Q9Y6D5	Anti Tag CoIP	16866877

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Adult Liposarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08880	MYCBP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08881	MYCBP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MYCBP	VGNC	VGNC:110177
Mus musculus	MYCBP	MGD	MGI:1891750
Rattus norvegicus	MYCBP	RGD	RGD:2320727

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