2. Gene
  3. Vcp - valosin containing protein Gene

Vcp - valosin containing protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as p97; CDC48; p97/VCP; 3110001E05

Gene ID: 269523 | Gene type: protein coding

About Vcp

Chromosome 4: 42,979,963-43,000,507 reverse strand.GRCm39:CM000997.3

This gene has 5 transcripts (splice variants), 229 orthologues, 6 paralogues and is associated with 37 phenotypes. Ubiquitous expression in placenta adult (RPKM 19.8), adrenal adult (RPKM 19.) and 28 other tissues.

Summary

Enables several functions, including ATP hydrolysis activity; K48-linked polyubiquitin modification-dependent protein binding activity; and adenyl ribonucleotide binding activity. Involved in ATP metabolic process; positive regulation of mitochondrial membrane potential; and proteasomal protein catabolic process. Acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process; aggresome assembly; and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum membrane and synapse. Part of ATPase complex; VCP-NSFL1C complex; and endoplasmic reticulum membrane. Is expressed in several structures, including cerebral cortex; early embryo; gonad; gut; and triceps surae muscle. Used to study inclusion body myopathy with Paget disease of bone and frontotemporal dementia. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein). [provided by Alliance of Genome Resources, Apr 2022]

Vcp Products(1)

mRNA Protein Name
NM_009503.4 NP_033529.3 transitional endoplasmic reticulum ATPase
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ADP binding IMP
IMP: Inferred from mutant phenotype
15740751 MGI
enables ATP binding IDA
IDA: Inferred from direct assay
12847084 MGI
enables ATP binding IMP
IMP: Inferred from mutant phenotype
15740751 MGI
enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
12847084 MGI
enables K48-linked polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
12847084 MGI
enables MHC class I protein binding IDA
IDA: Inferred from direct assay
12847084 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
15740751 MGI
enables polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
11483959 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10811609 MGI
enables ubiquitin-specific protease binding IPI
IPI: Inferred from physical interaction
17000876 MGI
Biological Process GO Annotation Evidence Reference Source
involved in ATP metabolic process IDA
IDA: Inferred from direct assay
12847084 MGI
involved in ERAD pathway EXP
EXP: Inferred from Experiment
12847084 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
14561754 MGI
acts upstream of or within aggresome assembly IGI
IGI: Inferred from genetic interaction
16810319 MGI
involved in positive regulation of mitochondrial membrane potential IMP
IMP: Inferred from mutant phenotype
23498975 MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
26692333 MGI
involved in retrograde protein transport, ER to cytosol EXP
EXP: Inferred from Experiment
12847084 MGI
involved in retrograde protein transport, ER to cytosol IMP
IMP: Inferred from mutant phenotype
12847084 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IGI
IGI: Inferred from genetic interaction
16810319 MGI
Cellular Component GO Annotation Evidence Reference Source
part of ATPase complex IMP
IMP: Inferred from mutant phenotype
15740751 MGI
part of Derlin-1 retrotranslocation complex IDA
IDA: Inferred from direct assay
15215856 MGI
part of VCP-NPL4-UFD1 AAA ATPase complex EXP
EXP: Inferred from Experiment
22232657 MGI
part of VCP-NPL4-UFD1 AAA ATPase complex IDA
IDA: Inferred from direct assay
10811609 MGI
part of VCP-NPL4-UFD1 AAA ATPase complex IPI
IPI: Inferred from physical interaction
12847084 MGI
part of VCP-NSFL1C complex IPI
IPI: Inferred from physical interaction
10811609 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
12847084 MGI
part of protein-containing complex IPI
IPI: Inferred from physical interaction
17785525 MGI
is active in synapse EXP
EXP: Inferred from Experiment
16635246 MGI
is active in synapse IDA
IDA: Inferred from direct assay
16635246 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Vcp Protein Structure

CDC48

CDC48: cl36852 (24 - 763)

  • 0
  • 200
  • 400
  • 600
  • 806 a.a.
Protein Preferred Names Protein Names

transitional endoplasmic reticulum ATPase

15S Mg(2+)-ATPase p97 subunit

AAA ATPase p97

Inv protein

TER ATPase

homolog of yeast cdc48

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12861 CB-5083 Inhibitor 99.90% Phase 1
Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15713 NMS-873 Inhibitor 99.87% Unkown
HY-123872 MSC1094308 Inhibitor 99.89% Unkown
HY-128870 Mal-PEG2-VCP-Eribulin 99.82% Unkown
HY-157508 VCP Activator 1 Activator 99.71% Unkown
HY-15714 NMS-859 Inhibitor 98.05% Unkown
HY-130084 Mal-PEG2-VCP-NB 98.25% Unkown
HY-124776 NPD8733 99.92% Unkown
HY-138233 KUS121 Modulator ≥98.0% Unkown
HY-RS15621 VCP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-128871 VCP-Eribulin / Unkown
HY-113608 VCP171 Modulator / Unkown
HY-139606 VCP/p97 inhibitor-1 Inhibitor / Unkown
HY-148122 NW 1028 Inhibitor / Unkown
HY-160981 Mal-PEG4-VCP-NB / Unkown
HY-160982 Mal-PEG3-VCP-NB / Unkown
HY-RS15622 Vcp Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS15623 Vcp Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vcp NCBI NCBI:7415