VCP - valosin containing protein Gene

Homo sapiens

Also known as p97; TERA; CDC48; FTDALS6

Gene ID: 7415 | Gene type: protein coding

About VCP

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:35,056,064-35,072,625 (from NCBI)

This gene has 36 transcripts (splice variants), 229 orthologues, 5 paralogues and is associated with 12 phenotypes. Ubiquitous expression in appendix (RPKM 60.7), thyroid (RPKM 56.9) and 25 other tissues.

Summary

This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients. [provided by RefSeq, Aug 2017]

VCP Products(3)

mRNA	Protein	Name
NM_001354927.2	NP_001341856.1	transitional endoplasmic reticulum ATPase isoform 2
NM_007126.5	NP_009057.1	transitional endoplasmic reticulum ATPase isoform 1
NM_001354928.2	NP_001341857.1	transitional endoplasmic reticulum ATPase isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	24129571	GOA
enables ATP hydrolysis activity	IMP IMP: Inferred from mutant phenotype	23349634	GOA
enables BAT3 complex binding	IPI IPI: Inferred from physical interaction	21636303	GOA
enables K48-linked polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	37816088	GOA
enables deubiquitinase activator activity	IDA IDA: Inferred from direct assay	22970133	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20512113	GOA
enables polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	11483959	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9452483	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	15362974	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	10364224	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	22590560	GOA
enables ubiquitin-like protein ligase binding	IPI IPI: Inferred from physical interaction	16186510	GOA
enables ubiquitin-modified protein reader activity	IDA IDA: Inferred from direct assay	29033132	GOA
enables ubiquitin-specific protease binding	IPI IPI: Inferred from physical interaction	22590560	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	16140914	GOA
involved in ERAD pathway	IDA IDA: Inferred from direct assay	17872946	GOA
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	20104022	GOA
involved in NADH metabolic process	IMP IMP: Inferred from mutant phenotype	23498975	GOA
involved in autophagosome maturation	IMP IMP: Inferred from mutant phenotype	20104022	GOA
involved in autophagy	IMP IMP: Inferred from mutant phenotype	20104022	GOA
involved in cellular response to arsenite ion	IMP IMP: Inferred from mutant phenotype	29804830	GOA
involved in cellular response to heat	IMP IMP: Inferred from mutant phenotype	29804830	GOA
involved in cellular response to misfolded protein	IMP IMP: Inferred from mutant phenotype	24089527	GOA
involved in cytoplasm protein quality control	IDA IDA: Inferred from direct assay	29033132	GOA
involved in double-strand break repair	IDA IDA: Inferred from direct assay	10855792	GOA
involved in endoplasmic reticulum stress-induced pre-emptive quality control	IMP IMP: Inferred from mutant phenotype	26565908	GOA
involved in endosome to lysosome transport via multivesicular body sorting pathway	IMP IMP: Inferred from mutant phenotype	21822278	GOA
involved in flavin adenine dinucleotide catabolic process	IMP IMP: Inferred from mutant phenotype	23498975	GOA
involved in macroautophagy	IMP IMP: Inferred from mutant phenotype	27753622	GOA
involved in negative regulation of hippo signaling	IGI IGI: Inferred from genetic interaction	38710747	GOA
involved in negative regulation of protein localization to chromatin	IDA IDA: Inferred from direct assay	35013556	GOA
involved in negative regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	23747190	GOA
involved in positive regulation of ATP biosynthetic process	IMP IMP: Inferred from mutant phenotype	23498975	GOA
involved in positive regulation of Lys63-specific deubiquitinase activity	IDA IDA: Inferred from direct assay	22970133	GOA
involved in positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	28689657	GOA
involved in positive regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	23498975	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	37816088	GOA
involved in positive regulation of oxidative phosphorylation	IMP IMP: Inferred from mutant phenotype	23498975	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	9452483	GOA
involved in positive regulation of protein K63-linked deubiquitination	IDA IDA: Inferred from direct assay	22970133	GOA
involved in positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	11483959	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	18775313	GOA
involved in proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	26565908	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	31387940	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	20104022	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	22120668	GOA
involved in protein-DNA covalent cross-linking repair	IDA IDA: Inferred from direct assay	32152270	GOA
involved in regulation of aerobic respiration	IMP IMP: Inferred from mutant phenotype	23498975	GOA
involved in regulation of protein localization to chromatin	IDA IDA: Inferred from direct assay	32152270	GOA
involved in retrograde protein transport, ER to cytosol	IDA IDA: Inferred from direct assay	15215856	GOA
involved in retrograde protein transport, ER to cytosol	IMP IMP: Inferred from mutant phenotype	25660456	GOA
involved in stress granule disassembly	IDA IDA: Inferred from direct assay	36692217	GOA
involved in stress granule disassembly	IMP IMP: Inferred from mutant phenotype	29804830	GOA
involved in translesion synthesis	IMP IMP: Inferred from mutant phenotype	23042605	GOA
involved in viral genome replication	IMP IMP: Inferred from mutant phenotype	22379090	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Derlin-1 retrotranslocation complex	IDA IDA: Inferred from direct assay	15215856	GOA
part of VCP-NPL4-UFD1 AAA ATPase complex	IPI IPI: Inferred from physical interaction	20414249	GOA
part of VCP-NSFL1C complex	IPI IPI: Inferred from physical interaction	21645854	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	27753622	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	29804830	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10855792	GOA
is active in cytosol	IMP IMP: Inferred from mutant phenotype	38710747	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15215856	GOA
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	24129571	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	17872946	GOA
located in lipid droplet	IDA IDA: Inferred from direct assay	23297223	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10855792	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16275660	GOA
part of proteasome complex	IDA IDA: Inferred from direct assay	9452483	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	21822278	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	22120668	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VCP Protein Structure

CDC48_N

CDC48_2

AAA

Vps4_C

0
200
400
600
806 a.a.

Protein Preferred Names

Protein Names

transitional endoplasmic reticulum ATPase

15S Mg(2+)-ATPase p97 subunit

TER ATPase

VCP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	VCP	P55072	ATG5	Homo sapiens	A9UGY9	Y2H Prey Pooling	25416956
Intra	VCP	P55072	VCF1	Homo sapiens	Q969W3	Validated Y2H	32296183
Intra	VCP	P55072	VCF1	Homo sapiens	Q969W3	Y2H Prey Pooling	25416956
Intra	VCP	P55072	VCF1	Homo sapiens	Q969W3	Anti Tag CoIP	33961781
Intra	VCP	P55072	AMFR	Homo sapiens	Q9UKV5	Filter Binding	16275660
Intra	VCP	P55072	AMFR	Homo sapiens	Q9UKV5	Pull Down	26712280
Intra	VCP	P55072	AMFR	Homo sapiens	Q9UKV5	Pull Down	16275660
Intra	VCP	P55072	AMFR	Homo sapiens	Q9UKV5	IF	16275660
Intra	VCP	P55072	PTPN3	Homo sapiens	P26045	Anti Tag CoIP	10364224
Intra	VCP	P55072	FAF2	Homo sapiens	Q96CS3	Anti Tag CoIP	35271311
Intra	VCP	P55072	FAF2	Homo sapiens	Q96CS3	BRET	29997244
Intra	VCP	P55072	UBXN1	Homo sapiens	Q04323	Y2H Prey Pooling	25416956
Intra	VCP	P55072	METTL17	Homo sapiens	Q9H7H0-2	Validated Y2H	32296183
Intra	VCP	P55072	FCHSD2	Homo sapiens	O94868	Y2H	18654987
Cross	VCP	P55072	Cul1	Mus musculus	Q9WTX6	Anti Tag CoIP	22466964
Intra	VCP	P55072	UBXN2B	Homo sapiens	Q14CS0	Anti Tag CoIP	35271311
Intra	VCP	P55072	UBXN2B	Homo sapiens	Q14CS0	Validated Y2H	32296183
Intra	VCP	P55072	UBXN2B	Homo sapiens	Q14CS0	BRET	29997244
Intra	VCP	P55072	UBXN2B	Homo sapiens	Q14CS0	Y2H Prey Pooling	25416956
Intra	VCP	P55072	UBXN7	Homo sapiens	O94888	Anti Tag CoIP	18775313
Intra	VCP	P55072	UBXN2A	Homo sapiens	P68543	Y2H	21900206
Intra	VCP	P55072	UBXN2A	Homo sapiens	P68543	Validated Y2H	32296183
Intra	VCP	P55072	UBXN2A	Homo sapiens	P68543	Anti Tag CoIP	35271311
Intra	VCP	P55072	UBXN2A	Homo sapiens	P68543	BRET	29997244
Intra	VCP	P55072	ASPSCR1	Homo sapiens	Q9BZE9	Validated Y2H	25416956
Intra	VCP	P55072	ASPSCR1	Homo sapiens	Q9BZE9	Y2H Array	25416956
Intra	VCP	P55072	ASPSCR1	Homo sapiens	Q9BZE9	Anti Tag CoIP	26496610
Intra	VCP	P55072	ASPSCR1	Homo sapiens	Q9BZE9	Y2H	21900206
Intra	VCP	P55072	ASPSCR1	Homo sapiens	Q9BZE9	BRET	29997244
Intra	VCP	P55072	UBXN8	Homo sapiens	O00124	Anti Tag CoIP	35271311
Intra	VCP	P55072	UBXN8	Homo sapiens	O00124	Lumier	29997244
Intra	VCP	P55072	UBXN8	Homo sapiens	O00124	BRET	29997244
Intra	VCP	P55072	UBXN6	Homo sapiens	Q9BZV1	Anti Tag CoIP	35271311
Intra	VCP	P55072	UBXN6	Homo sapiens	Q9BZV1	Lumier	29997244
Intra	VCP	P55072	UBXN6	Homo sapiens	Q9BZV1	Anti Tag CoIP	18775313
Intra	VCP	P55072	UBXN6	Homo sapiens	Q9BZV1	Y2H	18656546
Intra	VCP	P55072	UBXN6	Homo sapiens	Q9BZV1	BRET	29997244
Intra	VCP	P55072	UBXN6	Homo sapiens	Q9BZV1	GMS	18656546
Intra	VCP	P55072	UBXN10	Homo sapiens	Q96LJ8	BRET	29997244
Intra	VCP	P55072	PLAA	Homo sapiens	Q9Y263	Validated Y2H	32296183
Intra	VCP	P55072	PLAA	Homo sapiens	Q9Y263	Anti Tag CoIP	35271311
Intra	VCP	P55072	PLAA	Homo sapiens	Q9Y263	Validated Y2H	25416956
Intra	VCP	P55072	UFD1	Homo sapiens	Q92890	X-Ray Diffraction	26712280
Intra	VCP	P55072	UFD1	Homo sapiens	Q92890	Anti Tag CoIP	18775313
Intra	VCP	P55072	UFD1	Homo sapiens	Q92890	Pull Down	26712280
Intra	VCP	P55072	UFD1	Homo sapiens	Q92890	Anti Tag CoIP	20414249
Intra	VCP	P55072	UFD1	Homo sapiens	Q92890	Anti Tag CoIP	35271311
Intra	VCP	P55072	NPLOC4	Homo sapiens	Q8TAT6	Anti Tag CoIP	35271311
Intra	VCP	P55072	NPLOC4	Homo sapiens	Q8TAT6	Anti Tag CoIP	18775313
Intra	VCP	P55072	NPLOC4	Homo sapiens	Q8TAT6	Anti Tag CoIP	20414249
Intra	VCP	P55072	NPLOC4	Homo sapiens	Q8TAT6	Anti Bait CoIP	20414249
Intra	VCP	P55072	NPLOC4	Homo sapiens	Q8TAT6	Anti Tag CoIP	33961781
Intra	VCP	P55072	RNF125	Homo sapiens	Q96EQ8	Pull Down	26471729
Intra	VCP	P55072	YOD1	Homo sapiens	Q5VVQ6	Validated Y2H	32296183
Intra	VCP	P55072	XAF1	Homo sapiens	Q6GPH4	Validated Y2H	32296183
Intra	VCP	P55072	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	VCP	P55072	YWHAZ	Homo sapiens	P63104	Y2H Array	21988832
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	Anti Tag CoIP	20414249
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	ITC	21645854
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	Anti Bait CoIP	20414249
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	ITC	26712280
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	Anti Tag CoIP	26496610
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	Y2H Prey Pooling	25416956
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	BRET	29997244
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	Validated Y2H	25416956
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	Anti Tag CoIP	33961781
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	Filter Binding	16275660
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	Lumier	29997244
Intra	VCP	P55072	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	25416956
Intra	VCP	P55072	PSMA1	Homo sapiens	P25786	Validated Y2H	25416956
Intra	VCP	P55072	RNF8	Homo sapiens	O76064	Y2H Array	25416956
Intra	VCP	P55072	GRB2	Homo sapiens	P62993	Y2H Array	25814554
Intra	VCP	P55072	GRB2	Homo sapiens	P62993	Lumier	25814554
Intra	VCP	P55072	CUL4A	Homo sapiens	Q13619	Anti Tag CoIP	22466964
Intra	VCP	P55072	UBXN4	Homo sapiens	Q92575	Anti Tag CoIP	18775313
Intra	VCP	P55072	UBXN4	Homo sapiens	Q92575	Anti Tag CoIP	35271311
Intra	VCP	P55072	UBXN4	Homo sapiens	Q92575	BRET	29997244
Intra	VCP	P55072	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	VCP	P55072	LNX1	Homo sapiens	Q8TBB1	Y2H Array	29892012
Intra	VCP	P55072	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
Intra	VCP	P55072	DTNB	Homo sapiens	O60941	Validated Y2H	25416956
Intra	VCP	P55072	DTNB	Homo sapiens	O60941	Y2H Array	31515488
Intra	VCP	P55072	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	25416956
Intra	VCP	P55072	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	VCP	P55072	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	25416956
Intra	VCP	P55072	CEP19	Homo sapiens	Q96LK0	Validated Y2H	25416956
Intra	VCP	P55072	CEP19	Homo sapiens	Q96LK0	Validated Y2H	32296183
Intra	VCP	P55072	CEP19	Homo sapiens	Q96LK0	Y2H Prey Pooling	25416956
Intra	VCP	P55072	UBOX5	Homo sapiens	O94941	Validated Y2H	25416956
Intra	VCP	P55072	UBOX5	Homo sapiens	O94941	Y2H Prey Pooling	25416956
Intra	VCP	P55072	UBE4B	Homo sapiens	B1AQ61	Anti Tag CoIP	20414249
Intra	VCP	P55072	ATXN3	Homo sapiens	P54252-1	Pull Down	16525503
Intra	VCP	P55072	ATXN3	Homo sapiens	P54252-1	Anti Bait CoIP	20414249
Intra	VCP	P55072	ATXN3	Homo sapiens	P54252-1	Peptide Array	16525503
Intra	VCP	P55072	ATXN3	Homo sapiens	P54252-1	Pull Down	12944474
Intra	VCP	P55072	ATXN3	Homo sapiens	P54252-1	Anti Tag CoIP	20414249

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VCP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71420	VCP Protein, Human (His)	P55072 (A2-N589)	≥95%

Related Diseases

Diseases

Alias

Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia

Ibmpfd	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia
Pagetoid Amyotrophic Lateral Sclerosis	Pagetoid Neuroskeletal Syndrome
Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia	Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia
Multisystem Proteinopathy	Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone
Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement
Lower Motor Neuron Degeneration With Paget-Like Bone Disease	Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone
Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia

Movement Disease

Movement Disorders

Movement Disorder

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1	Frontotemporal Dementia And/Or Motor Neuron Disease
Ftdmnd	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia
Alsftd	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1	Frontotemporal Dementia With Motor Neuron Disease
Ftdals	Ftd-Als
Ftd-Mnd	Frontotemporal Dementia With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1	Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1
Frontotemporal Lobar Degeneration	Grn-Related Frontotemporal Dementia

Myofibrillar Myopathy

Desmin Related Myopathy	Myotilinopathy
Myopathy, Myofibrillar	Alpha Beta Crystallinopathy
Desmin Storage Myopathy	Desminopathy
Filaminopathy	Protein Surplus Myopathy
Zaspopathy	Myofibrillar Myopathies
Myopathy, Myofibrillar, Desmin-Related	Myopathy, Desmin Storage
Mfm - [Myofibrillar Myopathy]

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Amyotrophic Lateral Sclerosis Type 15

Amyotrophic Lateral Sclerosis 15, With Or Without Frontotemporal Dementia	Als15
Amyotrophic Lateral Sclerosis 15

Supranuclear Palsy, Progressive, 1

Progressive Supranuclear Palsy	Steele-Richardson-Olszewski Syndrome
Supranuclear Palsy, Progressive	Psp
Progressive Supranuclear Ophthalmoplegia	PSNP1
Familial Progressive Supranuclear Palsy	Richardson'S Syndrome
Psp Syndrome	Progressive Supranuclear Palsy 1
Supranuclear Palsy Progressive	Ophthalmoplegia, Supranuclear, Progressive
Steele-Richardson-Olszewksi Syndrome

Amyotrophic Lateral Sclerosis 16, Juvenile

Amyotrophic Lateral Sclerosis Type 16	ALS16
Amyotrophic Lateral Sclerosis 16	Sclerosis, Lateral, Amyotrophic, Type 16, Juvenile

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 1

Ibmpfd1	Msp1
Multisystem Proteinopathy 1

Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 2

Ibmpfd2	Msp2
Multisystem Proteinopathy 2

Amyotrophic Lateral Sclerosis 6 With Or Without Frontotemporal Dementia

ALS6	Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia
Amyotrophic Lateral Sclerosis 6 Without Frontotemporal Dementia	Amyotrophic Lateral Sclerosis 6

Muscle Tissue Disease

Dysgraphia

Agraphia

Werner Syndrome

Werner'S Syndrome	WRN
Adult Progeria	Ws
Adult Premature Ageing Syndrome	Adult Premature Aging Syndrome
Werners Syndrome

Aphasia

Dementia

Dementias	Presenile Dementia
Alzheimer Type Dementia	Alzheimer Sclerosis
Alzheimer Disease Dementia	Alzheimer Dementia
Primary Degenerative Alzheimer Type Dementia	End Stage Alzheimer'S Dementia
Alzheimer'S Type Atypical Dementia	Alzheimer Type Presenile Dementia
Early Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 2
Dementia In Alzheimer Disease With Early Onset	Early Onset Alzheimer Type Dementia, Uncomplicated
Primary Degenerative Alzheimer Type Dementia, Early Onset	Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated
Alzheimer Disease Dementia With Early Onset	Presenile Sclerosis
Presenile Brain Sclerosis	Presenile Alzheimer Brain Sclerosis
Late Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 1
Dementia In Alzheimer Disease With Late Onset	Primary Degenerative Alzheimer Type Dementia, Late Onset
Sdat - [Senile Dementia, Alzheimer Type]	Alzheimer Disease Dementia With Late Onset
Late Onset Alzheimer Brain Sclerosis	Senile Alzheimer Brain Disease
Senile Alzheimer Brain Sclerosis	Senile Primary Degenerative Alzheimer Type Dementia
Senile Dementia Of The Alzheimer Type	Arteriosclerotic Dementia
Strategic-Infarct Dementia	Post Stroke Dementia
Vascular Cognitive Impairment	Vascular Dementia
Dementia Of The Lewy Body Type	Dementia With Lewy Bodies
Sdlt - [Senile Dementia Of The Lewy Body Type]	Senile Dementia Of The Lewy Body Type
Alcohol-Related Dementia	Alcoholic Dementia Nos
Alcohol-Induced Dementia	Alcoholic Brain Syndrome
Chronic Alcoholic Brain Syndrome	Alcohol Dementia
Late Onset Alcoholic Psychosis	Residual And Late-Onset Alcohol-Induced Psychotic Disorder
Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder	Late-Onset Psychoactive Substance-Induced Psychotic Disorder
Inhalant Dementia	Volatile Solvents Dementia
Dementia In Paralysis Agitans	Pdd - [Parkinson Disease Dementia]
Dementia Syndrome Of Parkinson Disease	Dementia In Parkinson Disease
Parkinson Related Dementia	Dementia In Huntington Chorea
Hiv - [Human Immunodeficiency Virus] Dementia	Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex
Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex	Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex
Aids Related Dementia	Dementia Due To Niacin Deficiency

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7

Ftd3	Frontotemporal Dementia, Chromosome 3-Linked
Amyotrophic Lateral Sclerosis, Chmp2b-Related	Chromosome 3-Linked Frontotemporal Dementia
FTDALS7	Chmp2b-Related Frontotemporal Dementia
Amyotrophic Lateral Sclerosis 17, Formerly	Als17, Formerly
Amyotrophic Lateral Sclerosis Type 17	Dtm1
Ftd-3	Ftd-Chmp2b
Als17	Amyotrophic Lateral Sclerosis 17
Sclerosis, Lateral, Amyotrophic, Type 17	Dementia, Frontotemporal, Chromosome 3-Linked

Prosopagnosia

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Myositis

Idiopathic Inflammatory Myopathy	Idiopathic Inflammatory Myositis
Iim	Imm
Idiopathic Inflammatory Myopathies	Myopathy, Familial Idiopathic Inflammatory
Inflammatory Disorder Of Muscle	Idiopathic Inflammatory Myopathy, Familial
Inflammatory Myopathy, Idiopathic	Myopathies Idiopathic Inflammatory
Familial Idiopathic Inflammatory Myopathy

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Writing Disorder

Nominal Aphasia

Anomia

Anomic Aphasia

Tooth Disease

Tooth Diseases	Teeth Disease
Tooth Disorders

Motor Neuron Disease

Anterior Horn Cell Disease	Motor Neuron Diseases
Mnd - [Motor Neurone Disease]	Lou Gehrig Disease
Creeping Palsy	Creeping Paralysis
Bulbar Motor Neuron Disease	Bulbar Syndrome
Anterior Horn Cell Disorder	Hereditary Motor Neuron Disease

Dementia, Lewy Body

Lewy Body Dementia	Lewy Body Disease
Diffuse Lewy Body Disease	Dementia With Lewy Bodies
DLB	Autosomal Dominant Diffuse Lewy Body Disease
Cortical Lewy Body Disease	Dementia, Lewy Body, Susceptibility To
Lewy Body Dementia, Susceptibility To	Senile Dementia Of The Lewy Body Type
Dementia Of The Lewy Body Type	Lbd
Diffuse Lewy Body Disease With Gaze Palsy	Dysphasic Dementia Hereditary
Lewy Body Type Senile Dementia	Lewy Body Variant Of Alzheimer Disease
Lewy Bodies	Lewy Body
Dlbd - [Diffuse Lewy Body Disease]	Clbd - [Cortical Lewy Body Disease]

Mammary Paget'S Disease

Paget'S Disease	Mammary Paget Disease
Paget'S Disease Of The Breast	Paget Disease Of The Breast
Paget'S Disease Of The Nipple	Paget'S Disease, Mammary
Paget Cell Neoplasm	Paget Disease Of The Nipple
Pagets Disease Mammary	Osteitis Deformans

Inclusion Body Myopathy With Early-Onset Paget Disease With Or Without Frontotemporal Dementia 1

IBMPFD1	Multisystem Proteinopathy 1
Pagetoid Amyotrophic Lateral Sclerosis	Pagetoid Neuroskeletal Syndrome
Lower Motor Neuron Degeneration With Paget-Like Bone Disease	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia
Msp1	Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone
Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia 1	Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone
Inclusion Body Myopathy Without Early-Onset Paget Disease And Frontotemporal Dementia 1

Lateral Sclerosis

Primary Lateral Sclerosis	Adult-Onset Primary Lateral Sclerosis
Adult-Onset Pls	Motor Neuron Disease
Pls	Pls - [Primary Lateral Sclerosis]
Lateral Spinal Sclerosis	Lateral Complete Paralysis
Lateral Incomplete Paralysis	Lateral Paralysis

Cerebellar Disease

Cerebellar Diseases	Cerebellar Dysfunction
Cerebellar Abnormality	Cerebellar Disorders

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia	Adca
Pierre Marie Cerebellar Ataxia	Ataxia, Spinocerebellar
Sca	Autosomal Dominant Spinocerebellar Ataxia
Spinocerebellar Ataxias

Spinal And Bulbar Muscular Atrophy, X-Linked 1

Kennedy Disease	Sbma
Spinal And Bulbar Muscular Atrophy	Kennedy'S Disease
X-Linked Spinal And Bulbar Muscular Atrophy	SMAX1
Kd	Kennedy Spinal And Bulbar Muscular Atrophy
Spinobulbar Muscular Atrophy	Bulbospinal Muscular Atrophy, X-Linked
Bulbospinal Neuronopathy, X-Linked Recessive	Xbsn
Spinal And Bulbar Muscular Atrophy Of Kennedy	Bulbospinal Muscular Atrophy
X-Linked Bulbospinal Amyotrophy	Bulbo-Spinal Atrophy, X-Linked
Spinal Bulbar Muscular Atrophy	X-Linked Bulbo-Spinal Atrophy
X-Linked Spinal Bulbar Muscular Atrophy	X-Linked Bsma
X-Linked Bulbospinal Muscular Atrophy	Spinal And Bulbar Muscular Atrophy X-Linked 1
Bulbospinal Muscular Atrophy X-Linked	Bulbospinal Neuronopathy X-Linked Recessive
Kennedy Disease)	Kennedy Syndrome
Atrophy, Muscular, Spinal And Bulbar, Kennedy Type	Atrophy, Muscular, Spinobulbar
Bulbospinal Neuronopathy

Machado-Joseph Disease

SCA3	MJD
Spinocerebellar Ataxia 3	Azorean Disease
Spinocerebellar Ataxia Type 3	Azorean Neurologic Disease
Spinopontine Atrophy	Nigrospinodentatal Degeneration
Spinocerebellar Atrophy	Spinocerebellar Atrophy Iii
Spinocerebellar Atrophy Type 3	Azorean Ataxia
Azorean Disease Of The Nervous System	Machado Disease
Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia	Disease, Machado-Joseph
Ataxia, Spinocerebellar

Alzheimer Disease 7

Ad7	Alzheimer'S Disease 7
Alzheimer Disease, Familial, 7	Alzheimer Disease-7
Alzheimer Disease, Familial 7

Associative Agnosia

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis	Batten Disease
Ncl	Neuronal Ceroid-Lipofuscinoses
Lipofuscinosis, Ceroid, Neuronal	Juvenile Neuronal Ceroid Lipofuscinosis
Cerebromacular Dystrophy	Cerebromacular Degeneration
Ceroid-Lipofuscinosis	Ncl - [Neuronal Ceroid Lipofuscinosis]
Amaurotic Familial Idiocy	Amaurotic Idiocy
Amaurotic Idiot	Neuronal Lipofuscinosis
Pigmentary Retinal Lipoid Neuronal Heredodegeneration

Cortical Deafness

Agraphia

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Hsp
Spg	Strümpell-Lorrain Disease
Spastic Paraplegia, Hereditary	French Settlement Disease
Strumpell-Lorrain Syndrome	Fsp
Familial Spastic Paraparesis	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 6

FTDALS6	Amyotrophic Lateral Sclerosis 14 With Or Without Frontotemporal Dementia, Formerly
Als14, Formerly	Als14
Amyotrophic Lateral Sclerosis 14, With Or Without Frontotemporal Dementia	Sclerosis, Lateral, Amyotrophic, Type 14, With/Without Frontotemporal Dementia

Amyotrophic Lateral Sclerosis Type 14

Als14	Amyotrophic Lateral Sclerosis 14
Amyotrophic Lateral Sclerosis, With Or Without Frontotemporal Dementia	Amyotrophic Lateral Sclerosis 14 With Or Without Frontotemporal Dementia

Myopathy

Muscular Diseases

Myopathies

Spastic Paraplegia-Paget Disease Of Bone Syndrome

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Progressive Non-Fluent Aphasia

Non-Fluent Variant Ppa	Non-Fluent Primary Progressive Aphasia
Agramatic Variant Of Ppa	Agramatic Variant Of Primary Progressive Aphasia
Progressive Nonfluent Aphasia	Primary Progressive Non Fluent Aphasia
Primary Progressive Nonfluent Aphasia

Progressive Muscular Atrophy

Progressive Spinal Muscular Atrophy	Pure Progressive Muscular Atrophy
Pma	Hereditary Spinal Muscle Atrophy
Pma - [Progressive Muscular Atrophy]	Progressive Muscle Atrophy
Progressive Spinal Muscle Atrophy	Duchenne-Aran Atrophy
Duchenne-Aran Muscle Atrophy	Hereditary Sma - [Spinal Muscle Atrophy]

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Muscular Disease

Nonaka Myopathy

Gne Myopathy	Hibm
Distal Myopathy With Rimmed Vacuoles	Hereditary Inclusion Body Myopathy
Ibm2	Inclusion Body Myopathy, Quadriceps-Sparing
Qsm	Dmrv
Distal Myopathy, Nonaka Type	Inclusion Body Myopathy 2
Inclusion Body Myopathy, Autosomal Recessive	NM
Nonaka Distal Myopathy	Myopathy, Distal, With Or Without Rimmed Vacuoles
Inclusion Body Myopathy, Hereditary, Autosomal Recessive	Inclusion Body Myopathy Type 2
Quadriceps-Sparing Myopathy	Quadriceps Sparing Myopathy
Rimmed Vacuole Myopathy	Inclusion Body Myopathy 2, Autosomal Recessive, Formerly
Ibm2, Formerly	Hibm2
Hereditary Inclusion Body Myopathy Type 2	Inclusion Body Myopathy 2, Autosomal Recessive
Myopathy, Distal, With Rimmed Vacuoles	Inclusion Body Myopathy Autosomal Recessive
Myopathy, Inclusion Body, Type 2	Myopathy, Nonaka

Amyotrophic Lateral Sclerosis Type 6

Amyotrophic Lateral Sclerosis 6, Autosomal Recessive	Als6
Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia	Autosomal Recessive Amyotrophic Lateral Sclerosis 6
Sclerosis, Lateral, Amyotrophic, Type Type 6	Amyotrophic Lateral Sclerosis 6

Spinocerebellar Ataxia 2

Spinocerebellar Ataxia Type 2	SCA2
Amyotrophic Lateral Sclerosis 13	Spinocerebellar Degeneration With Slow Eye Movements
SDSEM	Spinocerebellar Atrophy Ii
Olivopontocerebellar Atrophy Ii	Opca2
Cerebellar Degeneration With Slow Eye Movements	Wadia-Swami Syndrome
Amyotrophic Lateral Sclerosis Type 13	ALS13
Olivopontocerebellar Atrophy Holguin Type	Spinocerebellar Ataxia Cuban Type
Olivopontocerebellar Atrophy, Holguin Type	Spinocerebellar Ataxia, Cuban Type
Amyotrophic Lateral Sclerosis, Susceptibility To, 13	Olivopontocerebellar Atrophy 2
Sca 2	Spinocerebellar Ataxia With Slow Eye Movements
Spinocerebellar Atrophy 2	Wadia Swami Syndrome
Opca Ii	Spinocerebellar Ataxia-2
Ataxia, Spinocerebellar, Type 2

Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2	CMT2E
CMT2S	CMT2Y
Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Disease Type 2y
Charcot-Marie-Tooth Disease Axonal Type 2s	Charcot-Marie-Tooth Disease, Axonal, Type 2s
Charcot-Marie-Tooth Disease, Type 2e	Hereditary Motor And Sensory Neuropathy Type 2
Charcot-Marie-Tooth Neuropathy, Type 2s	Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s
Charcot-Marie-Tooth Disease, Axonal, Type 2y	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y
Charcot-Marie-Tooth Neuropathy, Type 2y	Charcot-Marie-Tooth Disease, Type 2y
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Neuropathy Type 2e
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation	Cmt2 Due To Vcp Mutation
Charcot-Marie-Tooth Disease Type 2s	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease	Cmt2
Charcot-Marie-Tooth Neuropathy, Type 2e	Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type
Hereditary Motor And Sensory Neuropathy Okinawa Type	Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y
Charcot-Marie-Tooth Neuropathy Type 2y	Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s
Charcot-Marie-Tooth Neuropathy Type 2s	Charcot-Marie-Tooth Type 2
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y	Charcot-Marie-Tooth Disease 2e
Charcot-Marie-Tooth Disease Axonal Type 2e	Charcot-Marie-Tooth Disease Neuronal Type 2e
Charcot-Marie-Tooth Disease 2s	Charcot-Marie-Tooth Neuropathy Axonal Type 2s
Charcot-Marie-Tooth Disease 2y	Charcot-Marie-Tooth Disease, Type 2
Hereditary Motor And Sensory-Neuropathy Type Ii

Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3

Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like	Scd-Eds
EDSSPD3	Ehlers-Danlos Syndrome Spondylodysplastic Type 3
Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type	Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome
Slc39a13-Related Speds	Slc39a13-Related Spondylodysplastic Eds
Spondylocheirodysplastic Ehlers-Danlos Syndrome	Speds-Slc39a13
Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia	Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3

Neuromuscular Disease

Neuromuscular Diseases	Neuromuscular Disorders
Neuromuscular Disorder

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Adult-Onset Distal Myopathy Due To Vcp Mutation

Familial Expansile Osteolysis

FEO	Mccabe Disease
Osteolysis, Familial Expansile	Polyostotic Osteolytic Dysplasia, Hereditary Expansile
Hepod	Expansile Osteolysis, Familial
Eof	Hereditary Expansile Polyostotic Osteolytic Dysplasia

Pick Disease Of Brain

Pick Disease	Pick Disease Of The Brain
Lobar Atrophy Of Brain	Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions
Pick'S Disease	Behavioral Variant Of Frontotemporal Dementia
Dementia In Pick'S Disease	Lobar Atrophy Of The Brain
Bvftd	Bv-Ftd
PIDB	Picks Disease

Paget'S Disease Of Bone

Osteitis Deformans	Paget Disease Of Bone
Osseous Paget'S Disease	Paget Disease Of Bone, Familial
Bone Paget Disease	Familial Paget'S Disease Of Bone
Paget'S Bone Disease	Familial Paget Disease Of Bone
Paget Disease, Bone	Pdb
Pagets Bone Disease

Speech And Communication Disorders

Language Disorder	Communication Disorder
Language Disorders	Communication Disorders
Speech Language Disorder	Speech-Language Disorder
Communication Impairment	Speech And Language Disorder

Multisystem Proteinopathy

Perry Syndrome

Parkinsonism With Alveolar Hypoventilation And Mental Depression

PERRYS

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12861	CB-5083	Inhibitor	99.90%	Phase 1

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15713	NMS-873	Inhibitor	99.87%	Unkown
HY-123872	MSC1094308	Inhibitor	99.89%	Unkown
HY-128870	Mal-PEG2-VCP-Eribulin		99.82%	Unkown
HY-157508	VCP Activator 1	Activator	99.71%	Unkown
HY-15714	NMS-859	Inhibitor	98.05%	Unkown
HY-130084	Mal-PEG2-VCP-NB		98.25%	Unkown
HY-124776	NPD8733		99.92%	Unkown
HY-RS15621	VCP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-138233	KUS121	Modulator	≥98.0%	Unkown
HY-128871	VCP-Eribulin		/	Unkown
HY-113608	VCP171	Modulator	/	Unkown
HY-139606	VCP/p97 inhibitor-1	Inhibitor	/	Unkown
HY-148122	NW 1028	Inhibitor	/	Unkown
HY-160981	Mal-PEG4-VCP-NB		/	Unkown
HY-160982	Mal-PEG3-VCP-NB		/	Unkown
HY-RS15622	Vcp Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS15623	Vcp Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	VCP	VGNC	VGNC:66933
Rattus norvegicus	VCP	RGD	RGD:621595
Canis familiaris	VCP	VGNC	VGNC:48243
Mus musculus	VCP	MGD	MGI:99919
Bos taurus	VCP	VGNC	VGNC:36780
Macaca mulatta	VCP	VGNC	VGNC:78762
Others	VCP	NCBI