2. Gene
  3. Cul1 - cullin 1 Gene

Cul1 - cullin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cul-1

Gene ID: 26965 | Gene type: protein coding

About Cul1

Summary

Predicted to enable ubiquitin protein Ligase binding activity and ubiquitin-protein transferase activity. Predicted to contribute to ubiquitin protein Ligase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including animal organ morphogenesis; apoptotic process; and protein ubiquitination. Part of SCF ubiquitin Ligase complex. Is expressed in several structures, including adrenal gland; genitourinary system; immune system; neural retina; and telencephalon. Orthologous to human CUL1 (cullin 1). [provided by Alliance of Genome Resources, Apr 2022]

Cul1 Products(7)

mRNA Protein Name
NM_001355550.2 NP_001342479.1 cullin-1
NM_001355551.2 NP_001342480.1 cullin-1
NM_001410599.1 NP_001397528.1 cullin-1
NM_001410600.1 NP_001397529.1 cullin-1
NM_001410601.1 NP_001397530.1 cullin-1
NM_001410602.1 NP_001397531.1 cullin-1
NM_012042.5 NP_036172.1 cullin-1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12665572 MGI
Biological Process GO Annotation Evidence Reference Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
12140560 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
10508527 MGI
acts upstream of or within apoptotic process IMP
IMP: Inferred from mutant phenotype
10508527 MGI
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
10508527 MGI
acts upstream of or within protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
29593216 MGI
acts upstream of or within protein monoubiquitination IGI
IGI: Inferred from genetic interaction
21343341 MGI
Cellular Component GO Annotation Evidence Reference Source
part of SCF ubiquitin ligase complex IDA
IDA: Inferred from direct assay
12140560 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cullin-1

Cul1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
Cul1 Q9WTX6 UBXN7 Homo sapiens O94888
Anti Tag CoIP
22466964
Cross
Cul1 Q9WTX6 VCP Homo sapiens P55072
Anti Tag CoIP
22466964
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112134 CSN5i-3 Inhibitor 99.95% Unkown
HY-148602 KH-4-43 Inhibitor 99.99% Unkown
HY-159601 CSN5-IN-1 Inhibitor / Unkown
HY-RS03359 CUL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cul1 NCBI NCBI:8454