2. Gene
  3. UBXN7 - UBX domain protein 7 Gene

UBXN7 - UBX domain protein 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UBXD7

Gene ID: 26043 | Gene type: protein coding

About UBXN7

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:196,347,662-196,432,427 (from NCBI)

This gene has 6 transcripts (splice variants), 174 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 8.3), testis (RPKM 7.0) and 25 other tissues.

Summary

Enables ubiquitin binding activity and ubiquitin protein Ligase binding activity. Located in nuclear body. Part of VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]

UBXN7 Products(1)

mRNA Protein Name
NM_015562.2 NP_056377.1 UBX domain-containing protein 7
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
18775313 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18775313 GOA
enables ubiquitin binding IDA
IDA: Inferred from direct assay
18775313 GOA
enables ubiquitin protein ligase binding IDA
IDA: Inferred from direct assay
18775313 GOA
Cellular Component GO Annotation Evidence Reference Source
part of VCP-NPL4-UFD1 AAA ATPase complex IDA
IDA: Inferred from direct assay
18775313 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBXN7 Protein Structure

UBA_4

UBA_4: UBA-like domain (16 - 54)

Thioredoxin_7

Thioredoxin_7: Thioredoxin-like (153 - 233)

UBX

UBX: UBX domain (410 - 486)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 489 a.a.
Protein Preferred Names Protein Names

UBX domain-containing protein 7

UBX domain containing 7

UBXN7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
UBXN7 O94888 REL Homo sapiens Q04864-2
Validated Y2H
32296183
Intra
UBXN7 O94888 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
UBXN7 O94888 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
UBXN7 O94888 TRIM39 Homo sapiens Q9HCM9-2
Validated Y2H
32296183
Intra
UBXN7 O94888 TRIM39 Homo sapiens Q9HCM9-2
Y2H Array
32296183
Intra
UBXN7 O94888 TRIM39 Homo sapiens Q9HCM9-2
Y2H Prey Pooling
32296183
Intra
UBXN7 O94888 NFYC Homo sapiens Q13952-2
Y2H Prey Pooling
32296183
Intra
UBXN7 O94888 NFYC Homo sapiens Q13952-2
Validated Y2H
32296183
Intra
UBXN7 O94888 NFYC Homo sapiens Q13952-2
Y2H Array
32296183
Intra
UBXN7 O94888 FAM168A Homo sapiens Q92567-2
Y2H Array
32296183
Intra
UBXN7 O94888 FAM168A Homo sapiens Q92567-2
Y2H Prey Pooling
32296183
Intra
UBXN7 O94888 FAM168A Homo sapiens Q92567-2
Validated Y2H
32296183
Intra
UBXN7 O94888 CLEC19A Homo sapiens Q6UXS0
Validated Y2H
32296183
Intra
UBXN7 O94888 CLEC19A Homo sapiens Q6UXS0
Y2H Array
32296183
Intra
UBXN7 O94888 CLEC19A Homo sapiens Q6UXS0
Y2H Prey Pooling
32296183
Cross
UBXN7 O94888 Cul1 Mus musculus Q9WTX6
Anti Tag CoIP
22466964
Intra
UBXN7 O94888 ZNRF1 Homo sapiens Q8ND25
Validated Y2H
32296183
Intra
UBXN7 O94888 ZNRF1 Homo sapiens Q8ND25
Y2H Prey Pooling
32296183
Intra
UBXN7 O94888 ZNRF1 Homo sapiens Q8ND25
Y2H Array
32296183
Intra
UBXN7 O94888 TRIM8 Homo sapiens Q9BZR9
Validated Y2H
32296183
Intra
UBXN7 O94888 TRIM8 Homo sapiens Q9BZR9
Y2H Array
32296183
Intra
UBXN7 O94888 TRIM8 Homo sapiens Q9BZR9
Y2H Prey Pooling
32296183
Intra
UBXN7 O94888 MEOX1 Homo sapiens P50221
Validated Y2H
32296183
Intra
UBXN7 O94888 MEOX1 Homo sapiens P50221
Y2H Array
32296183
Intra
UBXN7 O94888 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
32296183
Intra
UBXN7 O94888 PAX5 Homo sapiens Q02548
Validated Y2H
32296183
Intra
UBXN7 O94888 PAX5 Homo sapiens Q02548
Y2H Prey Pooling
32296183
Intra
UBXN7 O94888 PAX5 Homo sapiens Q02548
Y2H Array
32296183
Intra
UBXN7 O94888 VCP Homo sapiens P55072
Anti Tag CoIP
33961781
Intra
UBXN7 O94888 VCP Homo sapiens P55072
Anti Tag CoIP
18775313
Intra
UBXN7 O94888 VCP Homo sapiens P55072
Validated Y2H
32296183
Intra
UBXN7 O94888 VCP Homo sapiens P55072
Anti Tag CoIP
22466964
Intra
UBXN7 O94888 VCP Homo sapiens P55072
Y2H Array
32296183
Intra
UBXN7 O94888 VCP Homo sapiens P55072
Y2H Prey Pooling
32296183
Intra
UBXN7 O94888 TRAF6 Homo sapiens Q9Y4K3
Y2H Prey Pooling
32296183
Intra
UBXN7 O94888 TRAF6 Homo sapiens Q9Y4K3
Validated Y2H
32296183
Intra
UBXN7 O94888 TRAF6 Homo sapiens Q9Y4K3
Y2H Array
32296183
Intra
UBXN7 O94888 CUL1 Homo sapiens Q13616
Anti Tag CoIP
18775313
Intra
UBXN7 O94888 CUL1 Homo sapiens Q13616
Anti Tag CoIP
22466964
Intra
UBXN7 O94888 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
UBXN7 O94888 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
UBXN7 O94888 HIF1A Homo sapiens Q16665
Anti Tag CoIP
18775313
Intra
UBXN7 O94888 CUL4B Homo sapiens Q13620
Anti Tag CoIP
18775313
Intra
UBXN7 O94888 CUL4B Homo sapiens Q13620
Anti Tag CoIP
22466964
Intra
UBXN7 O94888 CUL4A Homo sapiens Q13619
Anti Tag CoIP
22466964
Intra
UBXN7 O94888 CUL4A Homo sapiens Q13619
Anti Tag CoIP
18775313
Intra
UBXN7 O94888 CUL3 Homo sapiens Q13618
Anti Tag CoIP
22466964
Intra
UBXN7 O94888 CUL3 Homo sapiens Q13618
Anti Tag CoIP
18775313
Intra
UBXN7 O94888 CUL2 Homo sapiens Q13617
Anti Tag CoIP
18775313
Intra
UBXN7 O94888 CUL2 Homo sapiens Q13617
Anti Tag CoIP
22466964
Intra
UBXN7 O94888 TRIM62 Homo sapiens Q9BVG3
Validated Y2H
32296183
Intra
UBXN7 O94888 TRIM62 Homo sapiens Q9BVG3
Y2H Prey Pooling
32296183
Intra
UBXN7 O94888 TRIM62 Homo sapiens Q9BVG3
Y2H Array
32296183
Intra
UBXN7 O94888 NEDD8 Homo sapiens Q15843
Anti Tag CoIP
22466964
Intra
UBXN7 O94888 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra
UBXN7 O94888 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra
UBXN7 O94888 DAZAP2 Homo sapiens Q15038
Validated Y2H
32296183
Intra
UBXN7 O94888 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Intra
UBXN7 O94888 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
UBXN7 O94888 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Intra
UBXN7 O94888 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra
UBXN7 O94888 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
UBXN7 O94888 PAX6 Homo sapiens P26367
Validated Y2H
32296183
Intra
UBXN7 O94888 CRX Homo sapiens O43186
Y2H Array
32296183
Intra
UBXN7 O94888 CRX Homo sapiens O43186
Y2H Prey Pooling
32296183
Intra
UBXN7 O94888 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
UBXN7 O94888 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
UBXN7 O94888 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Immunodeficiency 46

Tfrc-Related Combined Immunodeficiency

IMD46

Cid Due To Tfrc Deficiency

Combined Immunodeficiency Due To Tfrc Deficiency
Chromosome 3q29 Deletion Syndrome

Chromosome 3q29 Microdeletion Syndrome

3q29 Microdeletion Syndrome

3q Subtelomere Deletion Syndrome

3q29 Recurrent Deletion

3qter Deletion

3q29 Deletion Syndrome

Monosomy 3q29

Microdeletion 3q29 Syndrome

Del(3)(Q29)

Monosomy 3qter

3q29 Deletion

Del3q29
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia

Ibmpfd

Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia

Pagetoid Amyotrophic Lateral Sclerosis

Pagetoid Neuroskeletal Syndrome

Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia

Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia

Multisystem Proteinopathy

Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone

Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia

Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement

Lower Motor Neuron Degeneration With Paget-Like Bone Disease

Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone

Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15399 UBXN7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus UBXN7 VGNC VGNC:36629
Rattus norvegicus UBXN7 RGD RGD:1306346
Macaca mulatta UBXN7 VGNC VGNC:79778
Canis familiaris UBXN7 VGNC VGNC:48102
Felis catus UBXN7 VGNC VGNC:102862
Mus musculus UBXN7 MGD MGI:2146388