UTP25 - UTP25 small subunit processome component Gene

Homo sapiens

Also known as DEF; DIEXF; C1orf107; DJ434O14.5

Gene ID: 27042 | Gene type: protein coding

About UTP25

Cytogenetic location: 1q32.2 Genomic coordinates (GRCh38): 1:209,827,972-209,857,565 (from NCBI)

This gene has 2 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in ovary (RPKM 3.8), thyroid (RPKM 2.8) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in several processes, including protein catabolic process; protein destabilization; and protein localization to nucleolus. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

UTP25 Products(1)

mRNA	Protein	Name
NM_014388.7	NP_055203.4	U3 small nucleolar RNA-associated protein 25 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23357851	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in embryonic organ development	IMP IMP: Inferred from mutant phenotype	27657329	GOA
involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	23357851	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	23357851	GOA
involved in protein localization to nucleolus	IDA IDA: Inferred from direct assay	27657329	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleolus	IDA IDA: Inferred from direct assay	23357851	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UTP25 Protein Structure

UTP25

0
200
400
600
756 a.a.

Protein Preferred Names

Protein Names

U3 small nucleolar RNA-associated protein 25 homolog

UTP25 small subunit processor component

UTP25 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UTP25	Q68CQ4	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	25416956
Intra	UTP25	Q68CQ4	MAGEA11	Homo sapiens	P43364-2	Validated Y2H	25416956
Intra	UTP25	Q68CQ4	MAGEA11	Homo sapiens	P43364-2	Y2H Array	25416956
Intra	UTP25	Q68CQ4	ZBTB10	Homo sapiens	Q96DT7-3	Y2H Prey Pooling	32296183
Intra	UTP25	Q68CQ4	ZBTB10	Homo sapiens	Q96DT7-3	Validated Y2H	32296183
Intra	UTP25	Q68CQ4	ZBTB10	Homo sapiens	Q96DT7-3	Y2H Array	32296183
Intra	UTP25	Q68CQ4	RUFY1	Homo sapiens	Q96T51-2	Y2H Prey Pooling	32296183
Intra	UTP25	Q68CQ4	RUFY1	Homo sapiens	Q96T51-2	Y2H Array	31515488
Intra	UTP25	Q68CQ4	RUFY1	Homo sapiens	Q96T51-2	Validated Y2H	32296183
Intra	UTP25	Q68CQ4	RUFY1	Homo sapiens	Q96T51-2	Y2H Array	32296183
Intra	UTP25	Q68CQ4	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	UTP25	Q68CQ4	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	UTP25	Q68CQ4	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	UTP25	Q68CQ4	MIPOL1	Homo sapiens	Q8TD10	Y2H Prey Pooling	25416956
Intra	UTP25	Q68CQ4	MIPOL1	Homo sapiens	Q8TD10	Y2H Array	25416956
Intra	UTP25	Q68CQ4	AP2M1	Homo sapiens	Q96CW1	Y2H Prey Pooling	32296183
Intra	UTP25	Q68CQ4	AP2M1	Homo sapiens	Q96CW1	Y2H Array	32296183
Intra	UTP25	Q68CQ4	AP2M1	Homo sapiens	Q96CW1	Anti Tag CoIP	33961781
Intra	UTP25	Q68CQ4	AP2M1	Homo sapiens	Q96CW1	Validated Y2H	32296183
Intra	UTP25	Q68CQ4	RUFY1	Homo sapiens	Q96T51	Y2H Prey Pooling	25416956
Intra	UTP25	Q68CQ4	RUFY1	Homo sapiens	Q96T51	Y2H Array	25416956
Intra	UTP25	Q68CQ4	TRIM62	Homo sapiens	Q9BVG3	Y2H Prey Pooling	32296183
Intra	UTP25	Q68CQ4	TRIM62	Homo sapiens	Q9BVG3	Validated Y2H	32296183
Intra	UTP25	Q68CQ4	TRIM62	Homo sapiens	Q9BVG3	Y2H Array	32296183
Intra	UTP25	Q68CQ4	TRIM9	Homo sapiens	Q9C026	Y2H Array	32296183
Intra	UTP25	Q68CQ4	TRIM9	Homo sapiens	Q9C026	Y2H Prey Pooling	32296183
Intra	UTP25	Q68CQ4	TRIM9	Homo sapiens	Q9C026	Validated Y2H	32296183
Intra	UTP25	Q68CQ4	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
Intra	UTP25	Q68CQ4	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	25416956
Intra	UTP25	Q68CQ4	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	UTP25	Q68CQ4	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	25416956
Intra	UTP25	Q68CQ4	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15578	UTP25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	UTP25	VGNC	VGNC:55764
Felis catus	UTP25	VGNC	VGNC:66905
Mus musculus	UTP25	MGD	MGI:2138080
Rattus norvegicus	UTP25	RGD	RGD:1359148
Bos taurus	UTP25	VGNC	VGNC:54509
Macaca mulatta	UTP25	VGNC	VGNC:79711

Name
Email *

	Sorry, but the email address you supplied was invalid.