2. Gene
  3. MIPOL1 - mirror-image polydactyly 1 Gene

MIPOL1 - mirror-image polydactyly 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CCDC193

Gene ID: 145282 | Gene type: protein coding

About MIPOL1

Cytogenetic location: 14q13.3-q21.1 Genomic coordinates (GRCh38): 14:37,197,937-37,585,618 (from NCBI)

This gene has 30 transcripts (splice variants) and 177 orthologues. Broad expression in prostate (RPKM 1.7), testis (RPKM 0.6) and 20 other tissues.

Summary

This gene encodes a coiled-coil domain-containing protein. The encoded protein may function as a tumor suppressor. A translocation that results in truncation of the protein encoded by this locus has been associated with mirror-image polydactyly, also known as Laurin-Sandrow Syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2010]

MIPOL1 Products(14)

mRNA Protein Name
NM_001195296.2 NP_001182225.1 mirror-image polydactyly gene 1 protein isoform 1
NM_001195297.2 NP_001182226.1 mirror-image polydactyly gene 1 protein isoform 1
NM_001388067.1 NP_001374996.1 mirror-image polydactyly gene 1 protein isoform 1
NM_001388068.1 NP_001374997.1 mirror-image polydactyly gene 1 protein isoform 1
NM_001388069.1 NP_001374998.1 mirror-image polydactyly gene 1 protein isoform 2
NM_001388070.1 NP_001374999.1 mirror-image polydactyly gene 1 protein isoform 3
NM_001388071.1 NP_001375000.1 mirror-image polydactyly gene 1 protein isoform 3
NM_001388072.1 NP_001375001.1 mirror-image polydactyly gene 1 protein isoform 3
NM_001388073.1 NP_001375002.1 mirror-image polydactyly gene 1 protein isoform 4
NM_001388074.1 NP_001375003.1 mirror-image polydactyly gene 1 protein isoform 5
NM_001388075.1 NP_001375004.1 mirror-image polydactyly gene 1 protein isoform 5
NM_001388077.1 NP_001375006.1 mirror-image polydactyly gene 1 protein isoform 6
NM_001412440.1 NP_001399369.1 mirror-image polydactyly gene 1 protein isoform 7
NM_138731.7 NP_620059.1 mirror-image polydactyly gene 1 protein isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
19667180 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mirror-image polydactyly gene 1 protein

MIPOL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra MIPOL1 Q8TD10 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra MIPOL1 Q8TD10 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra MIPOL1 Q8TD10 ZGPAT Homo sapiens Q8N5A5-2
Y2H Prey Pooling
25416956
Intra MIPOL1 Q8TD10 ZGPAT Homo sapiens Q8N5A5-2
Y2H Array
25416956
Intra MIPOL1 Q8TD10 RTP5 Homo sapiens Q14D33
Validated Y2H
25416956
Intra MIPOL1 Q8TD10 FBF1 Homo sapiens Q8TES7-6
Validated Y2H
25416956
Intra MIPOL1 Q8TD10 FBF1 Homo sapiens Q8TES7-6
Y2H Array
25416956
Intra MIPOL1 Q8TD10 FBF1 Homo sapiens Q8TES7-6
Y2H Prey Pooling
25416956
Intra MIPOL1 Q8TD10 TTC12 Homo sapiens Q9H892-2
Y2H Prey Pooling
26871637
Intra MIPOL1 Q8TD10 TTC12 Homo sapiens Q9H892-2
Validated Y2H
26871637
Intra MIPOL1 Q8TD10 TTC12 Homo sapiens Q9H892-2
Y2H Array
25416956
Intra MIPOL1 Q8TD10 TTC12 Homo sapiens Q9H892-2
Y2H Array
26871637
Intra MIPOL1 Q8TD10 SSX3 Homo sapiens Q99909
Y2H Array
31515488
Intra MIPOL1 Q8TD10 SSX3 Homo sapiens Q99909
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 SSX3 Homo sapiens Q99909
Y2H Array
25416956
Intra MIPOL1 Q8TD10 PBX4 Homo sapiens Q9BYU1
Y2H Prey Pooling
32296183
Intra MIPOL1 Q8TD10 PBX4 Homo sapiens Q9BYU1
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 PBX4 Homo sapiens Q9BYU1
Y2H Array
32296183
Intra MIPOL1 Q8TD10 MAGEA6 Homo sapiens P43360
Y2H Prey Pooling
25416956
Intra MIPOL1 Q8TD10 MAGEA6 Homo sapiens P43360
Y2H Prey Pooling
32296183
Intra MIPOL1 Q8TD10 MAGEA6 Homo sapiens P43360
Y2H Array
32296183
Intra MIPOL1 Q8TD10 MAGEA6 Homo sapiens P43360
Validated Y2H
25416956
Intra MIPOL1 Q8TD10 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra MIPOL1 Q8TD10 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra MIPOL1 Q8TD10 PPP1R13B Homo sapiens Q96KQ4
Y2H Prey Pooling
25416956
Intra MIPOL1 Q8TD10 PPP1R13B Homo sapiens Q96KQ4
Validated Y2H
25416956
Intra MIPOL1 Q8TD10 PPP1R13B Homo sapiens Q96KQ4
Y2H Array
25416956
Intra MIPOL1 Q8TD10 FAM124B Homo sapiens Q9H5Z6-2
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 SNAP91 Homo sapiens O60641-3
Y2H Prey Pooling
32296183
Intra MIPOL1 Q8TD10 SNAP91 Homo sapiens O60641-3
Y2H Array
32296183
Intra MIPOL1 Q8TD10 PRPF31 Homo sapiens Q8WWY3
Y2H Prey Pooling
25416956
Intra MIPOL1 Q8TD10 SNTG2 Homo sapiens Q9NY99-2
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 SNTG2 Homo sapiens Q9NY99-2
Y2H Array
32296183
Intra MIPOL1 Q8TD10 SNTG2 Homo sapiens Q9NY99-2
Y2H Prey Pooling
32296183
Intra MIPOL1 Q8TD10 HAUS1 Homo sapiens Q96CS2
Validated Y2H
25416956
Intra MIPOL1 Q8TD10 HAUS1 Homo sapiens Q96CS2
Y2H Prey Pooling
25416956
Intra MIPOL1 Q8TD10 NEBL Homo sapiens O76041
Y2H Array
25416956
Intra MIPOL1 Q8TD10 TXN2 Homo sapiens Q99757
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 TBC1D7 Homo sapiens Q9P0N9
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 KIAA1328 Homo sapiens Q86T90
Y2H Prey Pooling
32296183
Intra MIPOL1 Q8TD10 KIAA1328 Homo sapiens Q86T90
Y2H Array
32296183
Intra MIPOL1 Q8TD10 ZGPAT Homo sapiens Q8N5A5
Y2H Prey Pooling
25416956
Intra MIPOL1 Q8TD10 ATP5PO Homo sapiens P48047
Y2H Prey Pooling
25416956
Intra MIPOL1 Q8TD10 ATP5PO Homo sapiens P48047
Y2H Array
25416956
Intra MIPOL1 Q8TD10 MCM7 Homo sapiens P33993
Y2H Array
25416956
Intra MIPOL1 Q8TD10 MCM7 Homo sapiens P33993
Y2H Prey Pooling
25416956
Intra MIPOL1 Q8TD10 CCT3 Homo sapiens P49368
Y2H Array
25416956
Intra MIPOL1 Q8TD10 BYSL Homo sapiens Q13895
Y2H Prey Pooling
25416956
Intra MIPOL1 Q8TD10 BYSL Homo sapiens Q13895
Validated Y2H
25416956
Intra MIPOL1 Q8TD10 TSEN15 Homo sapiens Q8WW01
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 GADD45GIP1 Homo sapiens Q8TAE8
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 EIF4E2 Homo sapiens O60573
Validated Y2H
25416956
Intra MIPOL1 Q8TD10 EIF4E2 Homo sapiens O60573
Y2H Array
25416956
Intra MIPOL1 Q8TD10 SMARCE1 Homo sapiens Q969G3
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 SMARCE1 Homo sapiens Q969G3
Y2H Array
25416956
Intra MIPOL1 Q8TD10 UBE2K Homo sapiens P61086
Y2H Prey Pooling
25416956
Intra MIPOL1 Q8TD10 UBE2K Homo sapiens P61086
Validated Y2H
25416956
Intra MIPOL1 Q8TD10 ANKRD23 Homo sapiens Q86SG2
Y2H Prey Pooling
32296183
Intra MIPOL1 Q8TD10 ANKRD23 Homo sapiens Q86SG2
Y2H Array
32296183
Intra MIPOL1 Q8TD10 MYLIP Homo sapiens Q8WY64
Y2H Array
25416956
Intra MIPOL1 Q8TD10 MYLIP Homo sapiens Q8WY64
Y2H Prey Pooling
25416956
Intra MIPOL1 Q8TD10 FAM161A Homo sapiens Q3B820
Y2H Prey Pooling
32296183
Intra MIPOL1 Q8TD10 FAM161B Homo sapiens Q96MY7
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 STMN3 Homo sapiens Q9NZ72
Y2H Prey Pooling
32296183
Intra MIPOL1 Q8TD10 STMN3 Homo sapiens Q9NZ72
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 STMN3 Homo sapiens Q9NZ72
Y2H Array
32296183
Intra MIPOL1 Q8TD10 LENG1 Homo sapiens Q96BZ8
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 RBM41 Homo sapiens Q96IZ5
Y2H Prey Pooling
25416956
Intra MIPOL1 Q8TD10 RBM41 Homo sapiens Q96IZ5
Validated Y2H
25416956
Intra MIPOL1 Q8TD10 RBM41 Homo sapiens Q96IZ5
Y2H Array
25416956
Intra MIPOL1 Q8TD10 TCHP Homo sapiens Q9BT92
Y2H Prey Pooling
25416956
Intra MIPOL1 Q8TD10 TCHP Homo sapiens Q9BT92
Validated Y2H
25416956
Intra MIPOL1 Q8TD10 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 MMTAG2 Homo sapiens Q9BU76
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 RCOR3 Homo sapiens Q9P2K3
Y2H Prey Pooling
25416956
Intra MIPOL1 Q8TD10 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
25416956
Intra MIPOL1 Q8TD10 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 CCDC120 Homo sapiens Q96HB5
Y2H Array
32296183
Intra MIPOL1 Q8TD10 CCDC120 Homo sapiens Q96HB5
Y2H Prey Pooling
32296183
Intra MIPOL1 Q8TD10 CCDC120 Homo sapiens Q96HB5
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 BEX2 Homo sapiens Q9BXY8
Y2H Prey Pooling
25416956
Intra MIPOL1 Q8TD10 BEX2 Homo sapiens Q9BXY8
Y2H Array
25416956
Intra MIPOL1 Q8TD10 CDK18 Homo sapiens Q07002
Y2H Prey Pooling
25416956
Intra MIPOL1 Q8TD10 CDK18 Homo sapiens Q07002
Validated Y2H
25416956
Intra MIPOL1 Q8TD10 CDK18 Homo sapiens Q07002
Y2H Array
25416956
Intra MIPOL1 Q8TD10 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
Intra MIPOL1 Q8TD10 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
Intra MIPOL1 Q8TD10 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra MIPOL1 Q8TD10 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra MIPOL1 Q8TD10 UTP25 Homo sapiens Q68CQ4
Validated Y2H
25416956
Intra MIPOL1 Q8TD10 UTP25 Homo sapiens Q68CQ4
Y2H Array
29892012
Intra MIPOL1 Q8TD10 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 EAF1 Homo sapiens Q96JC9
Y2H Prey Pooling
25416956
Intra MIPOL1 Q8TD10 DAXX Homo sapiens Q9UER7
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 KIF9 Homo sapiens Q9HAQ2
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Intra MIPOL1 Q8TD10 TTC23 Homo sapiens Q5W5X9-3
Y2H Array
32296183
Intra MIPOL1 Q8TD10 TTC23 Homo sapiens Q5W5X9-3
Y2H Prey Pooling
32296183
Intra MIPOL1 Q8TD10 USH1C Homo sapiens Q9Y6N9
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Polydactyly

Non-Syndromic Polydactyly

Polydactyly, Postaxial

Postaxial Polydactyly

Supernumerary Digit

Extra Digits

Hyperdactyly

Polydactylia

Polydactylism

Supernumerary Digits
Laurin-Sandrow Syndrome

Sandrow Syndrome

Tetramelic Mirror-Image Polydactyly

Mirror-Image Polydactyly

Mirror Hands And Feet With Nasal Defects

Tmip

LSS

Mip

Mirror Hands And Feets-Nasal Defects Syndrome

Fibula And Ulna, Duplication Of, With Absence Of Tibia And Radius

Miccor Hands And Feet With Nasal Defects

Mipduplication Of Fibuland Ulna With Absence Of Tibia And Radius

Fibula Ulna Duplication Tibia Radius Absence

Laurin Sandrow Syndrome

Duplication Of Fibula And Ulna With Absence Of Tibia And Radius

Segmental Laurin-Sandrow Syndrome

Laurin-Sandrow Syndrome, Segmental
Bronchus Adenoma

Bronchial Adenoma

Adenoma Of The Bronchus
Acute Laryngitis

Acute Laryngitis Nos

Laryngeal Inflammation

Laryngitis Nos

Larynx Inflammation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08462 MIPOL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MIPOL1 VGNC VGNC:106823
Canis familiaris MIPOL1 VGNC VGNC:43243
Felis catus MIPOL1 VGNC VGNC:80911
Rattus norvegicus MIPOL1 RGD RGD:6504372
Mus musculus MIPOL1 MGD MGI:1920740
Macaca mulatta MIPOL1 VGNC VGNC:74801