SND1 - staphylococcal nuclease and tudor domain containing 1 Gene

Homo sapiens

Also known as p100; TDRD11; Tudor-SN

Gene ID: 27044 | Gene type: protein coding

About SND1

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:127,652,194-128,092,593 (from NCBI)

This gene has 16 transcripts (splice variants), 199 orthologues, 1 paralogue and is associated with 81 phenotypes. Ubiquitous expression in placenta (RPKM 45.9), thyroid (RPKM 41.6) and 25 other tissues.

Summary

This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and Other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016]

SND1 Products(1)

mRNA	Protein	Name
NM_014390.4	NP_055205.2	staphylococcal nuclease domain-containing protein 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables RISC complex binding	IDA IDA: Inferred from direct assay	28546213	GOA
enables RNA binding	IDA IDA: Inferred from direct assay	18453631	GOA
enables RNA endonuclease activity	IDA IDA: Inferred from direct assay	28546213	GOA
enables endonuclease activity	IDA IDA: Inferred from direct assay	18453631	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20643132	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in miRNA catabolic process	IDA IDA: Inferred from direct assay	28546213	GOA
involved in regulation of cell cycle process	IMP IMP: Inferred from mutant phenotype	28546213	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SND1 Protein Structure

SNase

TUDOR

SNase

0
200
400
600
800
910 a.a.

Protein Preferred Names

Protein Names

staphylococcal nuclease domain-containing protein 1

EBNA2 coactivator p100

SND1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SND1	Q7KZF4	MTDH	Homo sapiens	Q86UE4	Anti Bait CoIP	24981741
Intra	SND1	Q7KZF4	MTDH	Homo sapiens	Q86UE4	Anti Tag CoIP	24981741
Intra	SND1	Q7KZF4	MTDH	Homo sapiens	Q86UE4	Pull Down	24981741
Intra	SND1	Q7KZF4	G3BP1	Homo sapiens	Q13283	Anti Bait CoIP	20643132
Intra	SND1	Q7KZF4	PIWIL1	Homo sapiens	Q96J94	FPS	20937909
Intra	SND1	Q7KZF4	PIWIL1	Homo sapiens	Q96J94	ITC	20937909
Intra	SND1	Q7KZF4	PIWIL1	Homo sapiens	Q96J94	X-Ray Diffraction	20937909

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Posterior Pituitary Gland Neoplasm

Posterior Pituitary Tumor

Neoplasm Of The Posterior Pituitary

Pancreatic Acinar Cell Adenocarcinoma

Pancreatic Acinar Cell Carcinoma

Acinar Cell Adenocarcinoma Of The Pancreas

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115581A	Thymidine 3',5'-diphosphate tetrasodium		≥97.0%	Unkown
HY-155170	MTDH-SND1 blocker 1	Inhibitor	99.33%	Unkown
HY-160801	HKYK-0030	Inhibitor	99.38%	Unkown
HY-RS13488	SND1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-115581	Thymidine 3',5'-disphosphate	Inducer	/	Unkown
HY-168850	MTDH-SND1 blocker 2	Inducer	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SND1	MGD	MGI:1929266
Rattus norvegicus	SND1	RGD	RGD:631340
Bos taurus	SND1	VGNC	VGNC:35063
Macaca mulatta	SND1	VGNC	VGNC:77798
Felis catus	SND1	VGNC	VGNC:65528
Canis familiaris	SND1	VGNC	VGNC:46600

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