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HKYK-0030 is an inhibitor for MTDH-SND1 protein-protein interaction. HKYK-0030 exhibits inhibitory activity against cancer metastasis.

For research use only. We do not sell to patients.

HKYK-0030 Chemical Structure

HKYK-0030 Chemical Structure

CAS No. : 2923054-94-6

Size Price Stock Quantity
5 mg USD 240 In-stock
10 mg USD 385 In-stock
25 mg USD 770 In-stock
50 mg USD 1230 In-stock
100 mg USD 1950 In-stock
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Based on 1 publication(s) in Google Scholar

HKYK-0030 Related Antibodies

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Description

HKYK-0030 is an inhibitor for MTDH-SND1 protein-protein interaction. HKYK-0030 exhibits inhibitory activity against cancer metastasis[1].

Molecular Weight

382.78

Formula

C14H11ClN4O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NN2C=CC=C(NS(=O)(C3=CC(Cl)=CC=C3OC)=O)C2=N1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (261.25 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6125 mL 13.0623 mL 26.1247 mL
5 mM 0.5225 mL 2.6125 mL 5.2249 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.53 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.53 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6125 mL 13.0623 mL 26.1247 mL 65.3117 mL
5 mM 0.5225 mL 2.6125 mL 5.2249 mL 13.0623 mL
10 mM 0.2612 mL 1.3062 mL 2.6125 mL 6.5312 mL
15 mM 0.1742 mL 0.8708 mL 1.7416 mL 4.3541 mL
20 mM 0.1306 mL 0.6531 mL 1.3062 mL 3.2656 mL
25 mM 0.1045 mL 0.5225 mL 1.0450 mL 2.6125 mL
30 mM 0.0871 mL 0.4354 mL 0.8708 mL 2.1771 mL
40 mM 0.0653 mL 0.3266 mL 0.6531 mL 1.6328 mL
50 mM 0.0522 mL 0.2612 mL 0.5225 mL 1.3062 mL
60 mM 0.0435 mL 0.2177 mL 0.4354 mL 1.0885 mL
80 mM 0.0327 mL 0.1633 mL 0.3266 mL 0.8164 mL
100 mM 0.0261 mL 0.1306 mL 0.2612 mL 0.6531 mL
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HKYK-0030 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HKYK-00302923054-94-6HKYK0030HKYK 0030OthersmetastasisInhibitorinhibitorinhibit

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HKYK-0030
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HY-160801
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