GOLGA1 - golgin A1 Gene

Homo sapiens

Also known as golgin-97

Gene ID: 2800 | Gene type: protein coding

About GOLGA1

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:124,878,275-124,948,043 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 12.9), skin (RPKM 6.1) and 25 other tissues.

Summary

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein is associated with Sjogren's syndrome. [provided by RefSeq, Feb 2010]

GOLGA1 Products(1)

mRNA	Protein	Name
NM_002077.4	NP_002068.2	golgin subfamily A member 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	17724343	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	17488291	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GOLGA1 Protein Structure

GRIP

0
200
400
600
767 a.a.

Protein Preferred Names

Protein Names

golgin subfamily A member 1

gap junction protein, alpha 4, 37kD

GOLGA1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GOLGA1	Q92805	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	GOLGA1	Q92805	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	GOLGA1	Q92805	CEP57L1	Homo sapiens	Q8IYX8-2	Validated Y2H	25416956
Intra	GOLGA1	Q92805	ZNF774	Homo sapiens	Q6NX45	Y2H Array	32296183
Intra	GOLGA1	Q92805	ZNF774	Homo sapiens	Q6NX45	Y2H Prey Pooling	32296183
Intra	GOLGA1	Q92805	SLAIN1	Homo sapiens	Q8ND83	Y2H Array	32296183
Intra	GOLGA1	Q92805	SLAIN1	Homo sapiens	Q8ND83	Y2H Prey Pooling	32296183
Intra	GOLGA1	Q92805	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Prey Pooling	32296183
Intra	GOLGA1	Q92805	PPP1R13B	Homo sapiens	Q96KQ4	Validated Y2H	32296183
Intra	GOLGA1	Q92805	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Array	32296183
Intra	GOLGA1	Q92805	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	25416956
Intra	GOLGA1	Q92805	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	GOLGA1	Q92805	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	GOLGA1	Q92805	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	25416956
Intra	GOLGA1	Q92805	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	GOLGA1	Q92805	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	GOLGA1	Q92805	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	GOLGA1	Q92805	LZTS1	Homo sapiens	Q9Y250	Y2H Prey Pooling	32296183
Intra	GOLGA1	Q92805	LZTS1	Homo sapiens	Q9Y250	Validated Y2H	32296183
Intra	GOLGA1	Q92805	LZTS1	Homo sapiens	Q9Y250	Y2H Array	32296183
Intra	GOLGA1	Q92805	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	32296183
Intra	GOLGA1	Q92805	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	32296183
Intra	GOLGA1	Q92805	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	GOLGA1	Q92805	ZC2HC1C	Homo sapiens	Q53FD0-2	Y2H Prey Pooling	32296183
Intra	GOLGA1	Q92805	ZC2HC1C	Homo sapiens	Q53FD0-2	Y2H Array	32296183
Intra	GOLGA1	Q92805	EXOC4	Homo sapiens	Q96A65-2	Y2H Array	32296183
Intra	GOLGA1	Q92805	EXOC4	Homo sapiens	Q96A65-2	Y2H Prey Pooling	32296183
Intra	GOLGA1	Q92805	EXOC4	Homo sapiens	Q96A65-2	Validated Y2H	32296183
Intra	GOLGA1	Q92805	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	GOLGA1	Q92805	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	GOLGA1	Q92805	VPS52	Homo sapiens	Q8N1B4	Validated Y2H	25416956
Intra	GOLGA1	Q92805	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	32296183
Intra	GOLGA1	Q92805	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	25416956
Intra	GOLGA1	Q92805	VPS52	Homo sapiens	Q8N1B4	Y2H Array	32296183
Intra	GOLGA1	Q92805	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
Intra	GOLGA1	Q92805	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
Intra	GOLGA1	Q92805	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	GOLGA1	Q92805	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	GOLGA1	Q92805	KIAA1328	Homo sapiens	Q86T90	Y2H Prey Pooling	32296183
Intra	GOLGA1	Q92805	KIAA1328	Homo sapiens	Q86T90	Y2H Array	32296183
Intra	GOLGA1	Q92805	ATF4	Homo sapiens	P18848	Y2H Prey Pooling	32296183
Intra	GOLGA1	Q92805	ATF4	Homo sapiens	P18848	Y2H Array	25416956
Intra	GOLGA1	Q92805	ATF4	Homo sapiens	P18848	Y2H Array	32296183
Intra	GOLGA1	Q92805	ATF4	Homo sapiens	P18848	Y2H Prey Pooling	25416956
Intra	GOLGA1	Q92805	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	GOLGA1	Q92805	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

GOLGA1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83203	GOLGA1 Antibody (YA2948)	WB	Human

Related Diseases

Diseases

Alias

Robinow Syndrome, Autosomal Dominant 1

Autosomal Dominant Robinow Syndrome 1	DRS1
Robinow Dwarfism	Fetal Face Syndrome
Acral Dysostosis With Facial And Genital Abnormalities	Robinow, Autosomal Dominant Syndrome, Type 1

Spastic Paraplegia 50, Autosomal Recessive

Hereditary Spastic Paraplegia 50	SPG50
Ap-4 Deficiency Syndrome	Ap-4-Associated Hereditary Spastic Paraplegia
Adaptor Protein Complex 4 Deficiency	Cerebral Palsy, Spastic Quadriplegic, 3, Formerly
Cpsq3, Formerly	Autosomal Recessive Spastic Paraplegia 50
Cpsq3	Spastic Quadriplegic Cerebral Palsy 3
Ap-4 Deficiency	Ap-4-Associated Hsp
Paraplegia, Spastic, Autosomal Recessive, Type 50	Spastic Paraplegia-50, Autosomal Recessive

Geroderma Osteodysplasticum

Gerodermia Osteodysplastica	Geroderma Osteodysplastica
GO	Walt Disney Dwarfism
Type Of Gerodermia Osteodysplastica

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05582	GOLGA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GOLGA1	VGNC	VGNC:41338
Rattus norvegicus	GOLGA1	RGD	RGD:1311305
Bos taurus	GOLGA1	VGNC	VGNC:29483
Mus musculus	GOLGA1	MGD	MGI:1924149
Felis catus	GOLGA1	VGNC	VGNC:62637
Macaca mulatta	GOLGA1	VGNC	VGNC:82151

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