2. Gene
  3. CCR10 - C-C motif chemokine receptor 10 Gene

CCR10 - C-C motif chemokine receptor 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GPR2

Gene ID: 2826 | Gene type: protein coding

About CCR10

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,678,889-42,681,843 (from NCBI)

This gene has 3 transcripts (splice variants), 188 orthologues and 23 paralogues. Broad expression in fat (RPKM 3.5), colon (RPKM 2.5) and 15 other tissues.

Summary

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC Chemokines and are adjacent in CC Chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]

CCR10 Products(1)

mRNA Protein Name
NM_016602.3 NP_057686.2 C-C chemokine receptor type 10
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
26941067 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
18308860 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCR10 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (58 - 310)

  • 0
  • 100
  • 200
  • 300
  • 362 a.a.
Protein Preferred Names Protein Names

C-C chemokine receptor type 10

C-C CKR-10

Related Diseases

Diseases Alias
Mycosis Fungoides

Mycosis Fungoides Lymphoma

Alibert-Bazin Syndrome

Granuloma Fungoides

Classic Mycosis Fungoides

Mycosis Fungoides, Alibert-Bazin Type
Primary Cutaneous T-Cell Non-Hodgkin Lymphoma

Cutaneous T-Cell Lymphoma

Cutaneous T Cell Lymphoma

Lymphoma, T-Cell, Cutaneous

Ctcl

Lymphoma T-Cell Cutaneous
Sezary'S Disease

Sezary Syndrome

Sézary Syndrome

Sezary'S Lymphoma

Sezary Disease

Sezary Erythroderma

Sezary Lymphoma
Dermatitis

Eczema

Skin Inflammation

Inflammatory Dermatosis
Chancroid

Ulcus Molle, Skin

Chancroids

Bubo Due To Haemophilus Ducreyi

Soft Chancre

Ulcus Molle
Psoriasis
Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-116835 BI-6901 Antagonist 99.76% Unkown
HY-RS02150 CCR10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CCR10 VGNC VGNC:38911
Rattus norvegicus CCR10 RGD RGD:1310716
Mus musculus CCR10 MGD MGI:1096320
Macaca mulatta CCR10 VGNC VGNC:82119
Bos taurus CCR10 VGNC VGNC:26983
Felis catus CCR10 VGNC VGNC:98779
Others CCR10 NCBI