2. Gene
  3. FOXR1 - forkhead box R1 Gene

FOXR1 - forkhead box R1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FOXN5; DLNB13

Gene ID: 283150 | Gene type: protein coding

About FOXR1

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,971,761-118,981,287 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 82 orthologues, 42 paralogues and is associated with 42 phenotypes. Restricted expression toward testis (RPKM 1.2).

Summary

This gene encodes a member of the forkhead box (FOX) family of transcription factors. FOX family members are monomeric, helix-turn-helix proteins with a core DNA-binding domain of approximately 110 aa. Many FOX transcription factors play roles in determining cell fates during early development. This forkhead box protein lacks the C-terminal basic region found in many Other FOX family members. It is located within the 11q23.3 region which is commonly deleted in neuroblastomas. [provided by RefSeq, Jul 2008]

FOXR1 Products(1)

mRNA Protein Name
NM_181721.3 NP_859072.1 forkhead box protein R1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
34723967 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
34723967 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
34723967 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
34723967 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
34723967 GOA
located in nucleus IDA
IDA: Inferred from direct assay
34723967 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXR1 Protein Structure

Forkhead

Forkhead: Forkhead domain (173 - 265)

  • 0
  • 100
  • 200
  • 292 a.a.
Protein Preferred Names Protein Names

forkhead box protein R1

forkhead box protein N5

FOXR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FOXR1 Q6PIV2 FLJ13057 Homo sapiens Q53SE7
Validated Y2H
25416956
Intra
FOXR1 Q6PIV2 FLJ13057 Homo sapiens Q53SE7
Y2H Prey Pooling
25416956
Intra
FOXR1 Q6PIV2 FLJ13057 Homo sapiens Q53SE7
Y2H Array
25416956
Intra
FOXR1 Q6PIV2 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra
FOXR1 Q6PIV2 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Intra
FOXR1 Q6PIV2 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Intra
FOXR1 Q6PIV2 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
FOXR1 Q6PIV2 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
FOXR1 Q6PIV2 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
FOXR1 Q6PIV2 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
Intra
FOXR1 Q6PIV2 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
Intra
FOXR1 Q6PIV2 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
Intra
FOXR1 Q6PIV2 MECP2 Homo sapiens P51608
Validated Y2H
32814053
Intra
FOXR1 Q6PIV2 MECP2 Homo sapiens P51608
Y2H Array
32814053
Intra
FOXR1 Q6PIV2 MECP2 Homo sapiens P51608
Y2H Pooling
32814053
Intra
FOXR1 Q6PIV2 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra
FOXR1 Q6PIV2 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra
FOXR1 Q6PIV2 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra
FOXR1 Q6PIV2 GMCL1 Homo sapiens Q96IK5
Validated Y2H
32296183
Intra
FOXR1 Q6PIV2 GMCL1 Homo sapiens Q96IK5
Y2H Array
32296183
Intra
FOXR1 Q6PIV2 GMCL1 Homo sapiens Q96IK5
Y2H Prey Pooling
32296183
Intra
FOXR1 Q6PIV2 TOR1A Homo sapiens O14656-2
Y2H Pooling
32814053
Intra
FOXR1 Q6PIV2 TOR1A Homo sapiens O14656-2
Validated Y2H
32814053
Intra
FOXR1 Q6PIV2 TOR1A Homo sapiens O14656-2
Y2H Array
32814053
Intra
FOXR1 Q6PIV2 SMN1 Homo sapiens Q16637
Validated Y2H
32814053
Intra
FOXR1 Q6PIV2 SMN1 Homo sapiens Q16637
Y2H Pooling
32814053
Intra
FOXR1 Q6PIV2 SMN1 Homo sapiens Q16637
Y2H Array
32814053
Intra
FOXR1 Q6PIV2 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
FOXR1 Q6PIV2 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
FOXR1 Q6PIV2 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
FOXR1 Q6PIV2 A2M Homo sapiens P01023
Validated Y2H
32814053
Intra
FOXR1 Q6PIV2 A2M Homo sapiens P01023
Y2H Array
32814053
Intra
FOXR1 Q6PIV2 A2M Homo sapiens P01023
Y2H Pooling
32814053
Intra
FOXR1 Q6PIV2 DPPA4 Homo sapiens Q7L190
Y2H Prey Pooling
32296183
Intra
FOXR1 Q6PIV2 DPPA4 Homo sapiens Q7L190
Validated Y2H
32296183
Intra
FOXR1 Q6PIV2 DPPA4 Homo sapiens Q7L190
Y2H Array
32296183
Intra
FOXR1 Q6PIV2 PPCDC Homo sapiens Q96CD2
Validated Y2H
32296183
Intra
FOXR1 Q6PIV2 PPCDC Homo sapiens Q96CD2
Y2H Prey Pooling
32296183
Intra
FOXR1 Q6PIV2 PPCDC Homo sapiens Q96CD2
Y2H Array
25416956
Intra
FOXR1 Q6PIV2 PPCDC Homo sapiens Q96CD2
Y2H Array
32296183
Intra
FOXR1 Q6PIV2 CEP19 Homo sapiens Q96LK0
Validated Y2H
32296183
Intra
FOXR1 Q6PIV2 BANP Homo sapiens Q8N9N5
Y2H Prey Pooling
25416956
Intra
FOXR1 Q6PIV2 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Intra
FOXR1 Q6PIV2 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Intra
FOXR1 Q6PIV2 MEOX2 Homo sapiens P50222
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cns Neuroblastoma With Foxr2 Activation

Central Nervous System Neuroblastoma With Foxr2 Activation

Cns Nb-Foxr2

Cns Neuroblastoma, Foxr2-Activated
Central Nervous System Neuroblastoma
Central Nervous System Germ Cell Tumor

Central Nervous System Germ Cell Tumour

Germ Cell Tumor Of The Cns

Germ Cell Tumour Of The Cns
Lymphedema-Distichiasis Syndrome

Lymphedema With Distichiasis

Lymphedema-Distichiasis Syndrome With Renal Disease And Diabetes Mellitus

LPHDST

Distichiasis-Lymphedema Syndrome

Lymphedema Distichiasis Syndrome

Hereditary Lymphedema-Distichiasis Syndrome

Lymphedema Distichiasis
Hematologic Cancer

Hematologic Neoplasm

Hematologic Neoplasms

Hematologic Malignancies

Blood Cancer

Hematologic Malignancy

Hematological Tumors

Hematopoietic And Lymphoid System Tumor

Hematopoietic Cancer

Hematopoietic Neoplasm

Hematopoietic Tumors

Malignant Hematopoietic Neoplasm

Liquid Tumor

Hematopoietic Neoplasms
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05078 FOXR1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FOXR1 VGNC VGNC:40969
Rattus norvegicus FOXR1 RGD RGD:1309739
Macaca mulatta FOXR1 VGNC VGNC:107449
Bos taurus FOXR1 VGNC VGNC:29104
Felis catus FOXR1 VGNC VGNC:62347
Mus musculus FOXR1 MGD MGI:2685961