DPPA4 - developmental pluripotency associated 4 Gene

Homo sapiens

Also known as 2410091M23Rik

Gene ID: 55211 | Gene type: protein coding

About DPPA4

Cytogenetic location: 3q13.13 Genomic coordinates (GRCh38): 3:109,326,144-109,339,636 (from NCBI)

This gene has 8 transcripts (splice variants), 75 orthologues and 1 paralogue. Biased expression in testis (RPKM 2.8), bone marrow (RPKM 2.1) and 5 other tissues.

Summary

This gene encodes a nuclear factor that is involved in the maintenance of pluripotency in stem cells and essential for embryogenesis. The encoded protein has a scaffold-attachment factor A/B, acinus and PIAS (SAP) domain that binds DNA and is thought to modify chromatin. Mice with a homozygous knockout of the orthologous gene die during late embryonic development or within hours after birth. Knockout embryos are normal in size at embryonic day 18.5 but exhibit skeletal and lung tissue abnormalities. This gene, when mutated, is highly expressed in embryonal carcinomas, pluripotent germ cell tumors, and Other cancers and is thought to play an important role in tumor progression. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

DPPA4 Products(3)

mRNA	Protein	Name
NM_001348928.3	NP_001335857.1	developmental pluripotency-associated protein 4 isoform 2
NM_001348929.2	NP_001335858.1	developmental pluripotency-associated protein 4 isoform 3
NM_018189.4	NP_060659.3	developmental pluripotency-associated protein 4 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPPA4 Protein Structure

Dppa2_A

DCR

0
100
200
304 a.a.

Protein Preferred Names

Protein Names

developmental pluripotency-associated protein 4

DPPA4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DPPA4	Q7L190	SH3GL1	Homo sapiens	Q6FGM0	Validated Y2H	25416956
Intra	DPPA4	Q7L190	SH3GL1	Homo sapiens	Q6FGM0	Y2H Array	25416956
Intra	DPPA4	Q7L190	SH3GL1	Homo sapiens	Q6FGM0	Y2H Prey Pooling	25416956
Intra	DPPA4	Q7L190	EIF4A2	Homo sapiens	Q14240-2	Y2H Array	25416956
Intra	DPPA4	Q7L190	EIF4A2	Homo sapiens	Q14240-2	Y2H Prey Pooling	25416956
Intra	DPPA4	Q7L190	RPGRIP1	Homo sapiens	Q96KN7	Validated Y2H	25416956
Intra	DPPA4	Q7L190	RPGRIP1	Homo sapiens	Q96KN7	Y2H Array	25416956
Intra	DPPA4	Q7L190	CIR1	Homo sapiens	Q86X95-2	Validated Y2H	32296183
Intra	DPPA4	Q7L190	SNX33	Homo sapiens	Q8WV41	Validated Y2H	32296183
Intra	DPPA4	Q7L190	SNX33	Homo sapiens	Q8WV41	Y2H Array	32296183
Intra	DPPA4	Q7L190	SNX33	Homo sapiens	Q8WV41	Y2H Prey Pooling	32296183
Intra	DPPA4	Q7L190	MISP	Homo sapiens	Q8IVT2	Validated Y2H	32296183
Intra	DPPA4	Q7L190	TNIP1	Homo sapiens	Q15025	Y2H Prey Pooling	32296183
Intra	DPPA4	Q7L190	TNIP1	Homo sapiens	Q15025	Y2H Array	32296183
Intra	DPPA4	Q7L190	GRB2	Homo sapiens	P62993	Y2H Prey Pooling	25416956
Intra	DPPA4	Q7L190	SH3GL1	Homo sapiens	Q99961	Anti Tag CoIP	33961781
Intra	DPPA4	Q7L190	SH3GL1	Homo sapiens	Q99961	Anti Tag CoIP	28514442
Intra	DPPA4	Q7L190	SH3GL1	Homo sapiens	Q99961	Validated Y2H	32296183
Intra	DPPA4	Q7L190	SH3GL1	Homo sapiens	Q99961	Y2H	21516116
Intra	DPPA4	Q7L190	SH3GL1	Homo sapiens	Q99961	Y2H Prey Pooling	32296183
Intra	DPPA4	Q7L190	SH3GL1	Homo sapiens	Q99961	Y2H Array	32296183
Intra	DPPA4	Q7L190	SH3GL1	Homo sapiens	Q99961	Y2H Pooling	16169070
Intra	DPPA4	Q7L190	INO80B	Homo sapiens	Q9C086	Validated Y2H	32296183
Intra	DPPA4	Q7L190	EIF4A2	Homo sapiens	Q14240	Y2H Prey Pooling	25416956
Intra	DPPA4	Q7L190	EIF4A2	Homo sapiens	Q14240	Validated Y2H	25416956
Intra	DPPA4	Q7L190	GTPBP3	Homo sapiens	Q969Y2	Validated Y2H	32296183
Intra	DPPA4	Q7L190	TLK1	Homo sapiens	Q9UKI8	Validated Y2H	32296183
Intra	DPPA4	Q7L190	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	25416956
Intra	DPPA4	Q7L190	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	32296183
Intra	DPPA4	Q7L190	LDOC1	Homo sapiens	O95751	Y2H Array	25416956
Intra	DPPA4	Q7L190	LDOC1	Homo sapiens	O95751	Y2H Array	32296183
Intra	DPPA4	Q7L190	KAT14	Homo sapiens	Q9H8E8	Validated Y2H	32296183
Intra	DPPA4	Q7L190	GMPPB	Homo sapiens	Q9Y5P6	Validated Y2H	32296183
Intra	DPPA4	Q7L190	EAF1	Homo sapiens	Q96JC9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Astigmatism

Germ Cell And Embryonal Cancer

Germ Cell And Embryonal Neoplasm

Germ Cell Cancer

Malignant Germ Cell Tumor	Neoplasms, Germ Cell And Embryonal
Germ Cell Neoplasm	Germ Cell Tumour
Malignant Tumor Of The Germ Cell	Neoplasms Germ Cell
Malignant Germ Cell Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03972	DPPA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DPPA4	VGNC	VGNC:61609
Rattus norvegicus	DPPA4	RGD	RGD:1595070
Macaca mulatta	DPPA4	VGNC	VGNC:84188
Mus musculus	DPPA4	MGD	MGI:2157525

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