2. Gene
  3. GPR35 - G protein-coupled receptor 35 Gene

GPR35 - G protein-coupled receptor 35 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 2859 | Gene type: protein coding

About GPR35

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:240,605,430-240,633,159 (from NCBI)

This gene has 5 transcripts (splice variants), 228 orthologues, 16 paralogues and is associated with 1 phenotype. Biased expression in duodenum (RPKM 17.7), small intestine (RPKM 16.7) and 7 other tissues.

Summary

Enables C-X-C Chemokine Receptor activity. Involved in several processes, including chemokine-mediated signaling pathway; negative regulation of voltage-gated Calcium Channel activity; and positive regulation of cytosolic calcium ion concentration. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR35 Products(4)

mRNA Protein Name
NM_001195381.3 NP_001182310.1 G-protein coupled receptor 35 isoform b
NM_001195382.3 NP_001182311.1 G-protein coupled receptor 35 isoform b
NM_005301.5 NP_005292.2 G-protein coupled receptor 35 isoform a
NM_001394730.1 NP_001381659.1 G-protein coupled receptor 35 isoform b

GPR35 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (38 - 276)

  • 0
  • 100
  • 200
  • 309 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor 35

KYNA receptor

kynurenic acid receptor

Related Diseases

Diseases Alias
Short-Rib Thoracic Dysplasia 10 With Or Without Polydactyly

SRTD10

Short-Rib Thoracic Dysplasia 10 Without Polydactyly

Short Rib-Polydactyly Syndrome
Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis

PSC

Sclerosing Cholangitis

Cholangitis, Sclerosing

Cholangitis Primary Sclerosing

Psc - [Primary Sclerosing Cholangitis]
Microphthalmia, Isolated 1

Isolated Microphthalmia 1

MCOP1

Mcop

Anophthalmia, Clinical, Isolated

Microphthalmos, Autosomal Recessive
Retinitis Pigmentosa 71

RP71

Retinitis Pigmentosa, Type 71
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-100806 Kynurenic acid Agonist 98.58% Phase 1
HY-107512 Kynurenic acid sodium Agonist 99.79% Phase 1
HY-100806R Kynurenic acid (Standard) Agonist / Phase 1
Pre-clinical Phase
Bioactive Molecules (19)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W008613 Pamoic acid Agonist 98.63% Unkown
HY-B1816 Zaprinast Agonist 99.95% Unkown
HY-107537 CID 2745687 Agonist 98.07% Unkown
HY-107536 ML 145 97.04% Unkown
HY-100806S Kynurenic acid-d5 Agonist 98.35% Unkown
HY-W010907 Pamoic acid disodium Agonist ≥98.0% Unkown
HY-134801 CID1231538 99.74% Unkown
HY-101033 GPR35 agonist 1 99.22% Unkown
HY-149190 GPR35 agonist 5 Agonist 98.86% Unkown
HY-15705 GPR35 agonist 2 Agonist 98.84% Unkown
HY-107538 YE120 Agonist 99.80% Unkown
HY-107539 GPR35 agonist 4 Agonist ≥99.0% Unkown
HY-169301 Gpr35 modulator 1 Modulator / Unkown
HY-101958 Tyrphostin 25 Agonist 99.00% Unkown
HY-169304 Gpr35 modulator 3 Modulator / Unkown
HY-131728 GPR35 agonist 3 Agonist 98.32% Unkown
HY-169303 Gpr35 modulator 2 Modulator / Unkown
HY-169302 GPR35 activator-1 Activator / Unkown
HY-106481 Bufrolin Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GPR35 VGNC VGNC:73134
Canis familiaris GPR35 VGNC VGNC:110509
Mus musculus GPR35 MGD MGI:1929509
Bos taurus GPR35 VGNC VGNC:29584
Rattus norvegicus GPR35 RGD RGD:1309404
Felis catus GPR35 VGNC VGNC:67425