GRK4 - G protein-coupled receptor kinase 4 Gene

Homo sapiens

Also known as IT11; GPRK4; GRK4a; GPRK2L

Gene ID: 2868 | Gene type: protein coding

About GRK4

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:2,963,571-3,040,760 (from NCBI)

This gene has 10 transcripts (splice variants), 187 orthologues and 7 paralogues. Biased expression in testis (RPKM 14.6) and brain (RPKM 0.7).

Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GRK4 Products(5)

mRNA	Protein	Name
NM_001004056.2	NP_001004056.1	G protein-coupled receptor kinase 4 isoform beta
NM_001004057.2	NP_001004057.1	G protein-coupled receptor kinase 4 isoform gamma
NM_001350173.2	NP_001337102.1	G protein-coupled receptor kinase 4 isoform 5
NM_005307.3	NP_005298.2	G protein-coupled receptor kinase 4 isoform delta
NM_182982.3	NP_892027.2	G protein-coupled receptor kinase 4 isoform alpha

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32707033	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in receptor internalization	IDA IDA: Inferred from direct assay	20074556	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRK4 Protein Structure

RGS

Pkinase

0
100
200
300
400
500
578 a.a.

Protein Preferred Names

Protein Names

G protein-coupled receptor kinase 4

G protein-coupled receptor kinase 2-like

Related Diseases

Diseases

Alias

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Hermansky-Pudlak Syndrome 3

HPS3	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial
Delta Storage Pool Disease	Hermansky-Pudlak Syndrome, Type 3
Platelet Storage Pool Deficiency	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05815	GRK4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GRK4	MGD	MGI:95801
Rattus norvegicus	GRK4	RGD	RGD:61858
Macaca mulatta	GRK4	VGNC	VGNC:73266
Canis familiaris	GRK4	VGNC	VGNC:41504
Bos taurus	GRK4	VGNC	VGNC:29655
Felis catus	GRK4	VGNC	VGNC:78506
Others	GRK4	NCBI

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