GRK6 - G protein-coupled receptor kinase 6 Gene

Homo sapiens

Also known as GPRK6

Gene ID: 2870 | Gene type: protein coding

About GRK6

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,425,523-177,442,891 (from NCBI)

This gene has 11 transcripts (splice variants), 209 orthologues and 7 paralogues. Broad expression in bone marrow (RPKM 27.2), lymph node (RPKM 19.5) and 23 other tissues.

Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GRK6 Products(4)

mRNA	Protein	Name
NM_001004105.3	NP_001004105.1	G protein-coupled receptor kinase 6 isoform C
NM_001004106.3	NP_001004106.1	G protein-coupled receptor kinase 6 isoform A
NM_001364164.2	NP_001351093.1	G protein-coupled receptor kinase 6 isoform D
NM_002082.4	NP_002073.2	G protein-coupled receptor kinase 6 isoform B

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-adrenergic receptor kinase activity	IDA IDA: Inferred from direct assay	20038610	GOA
enables beta-adrenergic receptor kinase activity	IMP IMP: Inferred from mutant phenotype	20038610	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20729810	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRK6 Protein Structure

RGS

Pkinase

0
100
200
300
400
500
576 a.a.

Protein Preferred Names

Protein Names

G protein-coupled receptor kinase 6

GRK6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GRK6	P43250	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	GRK6	P43250	GRK4	Homo sapiens	P32298	Pull Down	32707033
Cross	GRK6	P43250	ROM1	Bos taurus	P52205	Protein Kinase Assay	20729810

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GRK6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75799	GRK6 Protein, Human (sf9, His-GST)	P43250-2 (M1-R589)	≥95%

GRK6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83207	GRK6 Antibody (YA2952)	WB	Human, Mouse

Related Diseases

Diseases

Alias

Whim Syndrome 1

Whim Syndrome	Whims
Warts, Hypogammaglobulinemia, Infections, And Myelokathexis	WHIMS1
Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome	Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1
Myelokathexis, Isolated	Wilm
Warts-Infections-Leukopenia-Myelokatexis Syndrome	Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-128231	GRK6-IN-4	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-142812	GRK6-IN-1		99.61%	Unkown
HY-142817	GRK6-IN-2		99.39%	Unkown
HY-128311	GRK6-IN-3	Inhibitor	/	Unkown
HY-150021	GRK5-IN-3	Inhibitor	/	Unkown
HY-RS05817	GRK6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-159996	GRL093-22	Inhibitor	/	Unkown
HY-169678	GRK6-IN-5	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GRK6	VGNC	VGNC:73268
Felis catus	GRK6	VGNC	VGNC:67449
Bos taurus	GRK6	VGNC	VGNC:29657
Mus musculus	GRK6	MGD	MGI:1347078
Rattus norvegicus	GRK6	RGD	RGD:61986
Canis familiaris	GRK6	VGNC	VGNC:41506
Others	GRK6	NCBI

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