MAGEH1 - MAGE family member H1 Gene

Homo sapiens

Also known as APR1; APR-1; MAGEH

Gene ID: 28986 | Gene type: protein coding

About MAGEH1

Cytogenetic location: Xp11.21 Genomic coordinates (GRCh38): X:55,452,127-55,453,566 (from NCBI)

This gene has 1 transcript (splice variant), 170 orthologues and 37 paralogues.

Summary

This gene belongs to the non-CT (non Cancer/testis) subgroup of the melanoma-associated antigen (MAGE) superfamily. The encoded protein is likely associated with Apoptosis, cell cycle arrest, growth inhibition or cell differentiation. The protein may be involved in the atRA (all-trans retinoic acid) signaling through the STAT1-alpha (signal transducer and activator of transcription 1-alpha) pathway. [provided by RefSeq, Aug 2013]

MAGEH1 Products(1)

mRNA	Protein	Name
NM_014061.5	NP_054780.2	melanoma-associated antigen H1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAGEH1 Protein Structure

MAGE

0
100
200
219 a.a.

Protein Preferred Names

Protein Names

melanoma-associated antigen H1

apoptosis-related protein 1

MAGEH1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAGEH1	Q9H213	SH2B2	Homo sapiens	O14492-2	Y2H Array	32296183
Intra	MAGEH1	Q9H213	SH2B2	Homo sapiens	O14492-2	Y2H Prey Pooling	32296183
Intra	MAGEH1	Q9H213	HMBOX1	Homo sapiens	Q6NT76	Y2H Prey Pooling	25416956
Intra	MAGEH1	Q9H213	HMBOX1	Homo sapiens	Q6NT76	Y2H Array	25416956
Intra	MAGEH1	Q9H213	TNIP1	Homo sapiens	Q15025	Validated Y2H	25416956
Intra	MAGEH1	Q9H213	TNIP1	Homo sapiens	Q15025	Y2H Array	25416956
Intra	MAGEH1	Q9H213	TNIP1	Homo sapiens	Q15025	Y2H Prey Pooling	25416956
Intra	MAGEH1	Q9H213	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	MAGEH1	Q9H213	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	MAGEH1	Q9H213	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	MAGEH1	Q9H213	TRIM41	Homo sapiens	Q8WV44	Validated Y2H	25416956
Intra	MAGEH1	Q9H213	TRIM41	Homo sapiens	Q8WV44	Y2H Prey Pooling	25416956
Intra	MAGEH1	Q9H213	ZSCAN9	Homo sapiens	O15535	Y2H Array	25416956
Intra	MAGEH1	Q9H213	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	MAGEH1	Q9H213	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	MAGEH1	Q9H213	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Necatoriasis

Miner'S Anaemia	Negro Cachexia
Dochmiasis	Ground Itch Disease
Brickmaker'S Chlorosis	Coolie Itch Anaemia
Cachexia Aquosa	Dew Itch Anaemia
Brickmaker'S Anaemia	Tunnel Worker'S Anaemia
Egyptian Anaemia	Tunnel Worker'S Disease
Miner'S Cachexia	Greisinger Disease
Tropical Chlorosis	Egyptian Chlorosis
Tunnel Anaemia	Dochmiosis
Necatorosis	African Cachexia
Water Itch Anaemia	Infection Due To Necator Americanus
St Gotthard Disease	Gotthard Tunnel Disease

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Ostertagiasis

Ascaris Lumbricoides Infection

Ascariasis	Ascaris Lumbricoides Infection, Susceptibility To
Ascariasis, Susceptibility To	Ascariasis - Roundworm
Infection Due To Ascaris Lumbricoides	Ascaridiasis
Roundworm Infection	Ascaridia
Ascaridiosis	Ascaridosis
Ascariosis	Ascaris
Ascaris Lumbricoides Infestation	Ascaris Infection
Infection By Ascaridia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07979	MAGEH1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MAGEH1	VGNC	VGNC:42926
Bos taurus	MAGEH1	VGNC	VGNC:31145
Mus musculus	MAGEH1	MGD	MGI:1922875
Rattus norvegicus	MAGEH1	RGD	RGD:1359316

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