HIPK2 - homeodomain interacting protein kinase 2 Gene

Homo sapiens

Also known as PRO0593

Gene ID: 28996 | Gene type: protein coding

About HIPK2

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:139,561,570-139,777,998 (from NCBI)

This gene has 3 transcripts (splice variants), 213 orthologues and 12 paralogues. Ubiquitous expression in brain (RPKM 22.7), kidney (RPKM 17.9) and 24 other tissues.

Summary

This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many Other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

HIPK2 Products(2)

mRNA	Protein	Name
NM_001113239.3	NP_001106710.1	homeodomain-interacting protein kinase 2 isoform 2
NM_022740.5	NP_073577.3	homeodomain-interacting protein kinase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	14647468	GOA
enables SMAD binding	IPI IPI: Inferred from physical interaction	12874272	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12220523	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	19448668	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	33591310	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	12874272	GOA
enables virion binding	IPI IPI: Inferred from physical interaction	14990717	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response, signal transduction by p53 class mediator	IDA IDA: Inferred from direct assay	14647468	GOA
involved in SMAD protein signal transduction	IDA IDA: Inferred from direct assay	12874272	GOA
involved in negative regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	12874272	GOA
involved in negative regulation of ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	21628596	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	33591310	GOA
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	14678985	GOA
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	19046997	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	14647468	GOA
involved in positive regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	14678985	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	19448668	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with PML body	IDA IDA: Inferred from direct assay	14647468	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	33591310	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	33591310	GOA
located in nuclear body	IDA IDA: Inferred from direct assay	12874272	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12220523	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HIPK2 Protein Structure

Pkinase

0
200
400
600
800
1000
1198 a.a.

Protein Preferred Names

Protein Names

homeodomain-interacting protein kinase 2

hHIPk2

HIPK2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HIPK2	Q9H2X6	MECP2	Homo sapiens	P51608	Anti Bait CoIP	19820693
Intra	HIPK2	Q9H2X6	TP63	Homo sapiens	Q9H3D4	Protein Kinase Assay	21602882
Intra	HIPK2	Q9H2X6	DCAF7	Homo sapiens	P61962	Anti Tag CoIP	20940704
Intra	HIPK2	Q9H2X6	DCAF7	Homo sapiens	P61962	Y2H	20940704
Intra	HIPK2	Q9H2X6	DCAF7	Homo sapiens	P61962	Pull Down	20940704
Intra	HIPK2	Q9H2X6	EP300	Homo sapiens	Q09472	Pull Down	16917507
Intra	HIPK2	Q9H2X6	RUNX1	Homo sapiens	Q01196	Pull Down	16917507
Intra	HIPK2	Q9H2X6	RUNX1	Homo sapiens	Q01196	Anti Bait CoIP	16917507
Intra	HIPK2	Q9H2X6	RUNX1	Homo sapiens	Q01196	Protein Kinase Assay	16917507

Cross: Cross-species interaction Intra: Intraspecies interaction

HIPK2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82168	HIPK2 Antibody (YA1913)	WB, ICC/IF, IP, FC	Human, Mouse

Related Diseases

Diseases

Alias

Keratoacanthoma

Ka - [Keratoacanthoma]

Well-Differentiated Squamous Cell Carcinoma

Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations

Severe Congenital Encephalopathy Due To Mecp2 Mutation	Severe Neonatal-Onset Encephalopathy With Microcephaly
Encephalopathy, Neonatal Severe	Neonatal Severe Encephalopathy Due To Mecp2 Mutations
Mecp2-Related Severe Neonatal Encephalopathy	Methyl-Cytosine Phosphate Guanine Binding Protein 2 Related Severe Neonatal Encephalopathy
Severe Neonatal Encephalopathy Due To Mecp2 Mutations	ENS-MECP2
Encephalopathy, Neonatal, Severe

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100464	tBID	Inhibitor	99.03%	Unkown
HY-U00439A	Protein kinase inhibitor 1 hydrochloride	Inhibitor	≥98.0%	Unkown
HY-135906	CK2/ERK8-IN-1		≥99.0%	Unkown
HY-128439	BT173	Inhibitor	98.71%	Unkown
HY-U00439	Protein kinase inhibitor 1	Inhibitor	≥99.0%	Unkown
HY-RS06182	HIPK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HIPK2	MGD	MGI:1314872
Macaca mulatta	HIPK2	VGNC	VGNC:73391
Rattus norvegicus	HIPK2	RGD	RGD:1309349
Bos taurus	HIPK2	VGNC	VGNC:58380
Canis familiaris	HIPK2	VGNC	VGNC:41694
Felis catus	HIPK2	VGNC	VGNC:62820

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