Il18 - interleukin 18 Gene

Rattus norvegicus

Also known as IL-18; IL-1 gamma

Gene ID: 29197 | Gene type: protein coding

About Il18

Summary

Predicted to enable cytokine activity and interleukin-18 receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of cell population proliferation; and positive regulation of cytokine production. Located in apical plasma membrane; cytoplasm; and extracellular space. Used to study brain edema; fatty liver disease; heart disease; status epilepticus; and vasculitis. Biomarker of several diseases, including cardiac arrest; ischemia (multiple); lung disease (multiple); perinatal necrotizing enterocolitis; and urinary tract Infection. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18). [provided by Alliance of Genome Resources, Apr 2022]

Il18 Products(1)

mRNA	Protein	Name
NM_019165.2	NP_062038.2	interleukin-18

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12034039	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	12490070	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	12684057	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	11739527	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	18320471	RGD
involved in cellular response to parathyroid hormone stimulus	IEP IEP: Inferred from expression pattern	18165223	RGD
involved in cellular response to peptide hormone stimulus	IMP IMP: Inferred from mutant phenotype	12490070	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	18547159	RGD
involved in cellular response to type II interferon	IEP IEP: Inferred from expression pattern	18547159	RGD
involved in detection of mechanical stimulus involved in sensory perception of pain	IDA IDA: Inferred from direct assay	19853379	RGD
involved in digestive tract morphogenesis	IEP IEP: Inferred from expression pattern	21088234	RGD
involved in liver regeneration	IEP IEP: Inferred from expression pattern	24412291	RGD
involved in lung development	IEP IEP: Inferred from expression pattern	18952566	RGD
involved in negative regulation of neutrophil apoptotic process	IMP IMP: Inferred from mutant phenotype	20844839	RGD
involved in negative regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	22001439	RGD
involved in osteoblast differentiation	IEP IEP: Inferred from expression pattern	18165223	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	22001439	RGD
involved in positive regulation of blood vessel remodeling	IDA IDA: Inferred from direct assay	19717152	RGD
involved in positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	19497959	RGD
involved in positive regulation of collagen biosynthetic process	IDA IDA: Inferred from direct assay	20644901	RGD
involved in positive regulation of hepatocyte proliferation	IDA IDA: Inferred from direct assay	24412291	RGD
involved in positive regulation of interleukin-1 beta production	IEP IEP: Inferred from expression pattern	17623049	RGD
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	18547159	RGD
involved in positive regulation of male germ cell proliferation	IDA IDA: Inferred from direct assay	16002206	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17188500	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	22636674	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	22636674	RGD
involved in positive regulation of superoxide anion generation	IMP IMP: Inferred from mutant phenotype	19497959	RGD
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	17623049	RGD
involved in positive regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	11739527	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	19672068	RGD
involved in response to hypoxia	IMP IMP: Inferred from mutant phenotype	12122053	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	11086064	RGD
involved in sleep	IDA IDA: Inferred from direct assay	11506998	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	12032269	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	16002206	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interleukin-18

IFN-gamma-inducing factor	interferon gamma-inducing factor
interleukin-1 gamma

Recombinant Il18 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7210	IL-18 Protein, Rat	P97636-1 (H37-S194)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101092	QS-21	Activator	99.67%	Phase 3
HY-13205	Belnacasan	Inhibitor	99.99%	Phase 2

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990591	GSK-1070806	Inhibitor	99.50%	Phase 2
HY-P99491	Camoteskimab	Inhibitor	98.41%	Phase 1

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16990	Ac-YVAD-cmk	Inhibitor	98.94%	Unkown
HY-156413	NLRP3 agonist 1	Agonist	99.01%	Unkown
HY-19676	Pralnacasan	Inhibitor	99.83%	Unkown
HY-123879	BAA473		98.93%	Unkown
HY-150742	ODN 2336	Agonist	90.74%	Unkown
HY-149478	JT002	Inhibitor	99.49%	Unkown
HY-W176629	Hydrocotarnine	Inhibitor	99.59%	Unkown
HY-130413	Protectin D1		99.10%	Unkown
HY-147660	IMMH001	Agonist	98.10%	Unkown
HY-102019	NSC61610	Inhibitor	99.50%	Unkown
HY-160793	NSC80734	Inhibitor	98.08%	Unkown
HY-164426	HEI3090	Activator	99.04%	Unkown
HY-150742A	ODN 2336 sodium		90.74%	Unkown
HY-158024A	(S)-NDT-19795	Inhibitor	/	Unkown
HY-111662	Fc 11a-2	Inhibitor	/	Unkown
HY-130480	Fructose-arginine	Inhibitor	/	Unkown
HY-172162	LC-04-045		/	Unkown
HY-RS06708	IL18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06709	IL18BP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06710	IL18R1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06711	IL18RAP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-119337	CE-2072	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990312	ABT-325	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il18	NCBI	NCBI:3606
Canis lupus familiaris	Il18	NCBI
Mus musculus	Il18	NCBI	NCBI:16173

Name
Email *

	Sorry, but the email address you supplied was invalid.