2. Gene
  3. GTF2A2 - general transcription factor IIA subunit 2 Gene

GTF2A2 - general transcription factor IIA subunit 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as TF2A2; TFIIA; T18745; TFIIAS; HsT18745; TFIIA-12; TFIIA-gamma

Gene ID: 2958 | Gene type: protein coding

About GTF2A2

Cytogenetic location: 15q22.2 Genomic coordinates (GRCh38): 15:59,638,062-59,657,515 (from NCBI)

This gene has 10 transcripts (splice variants) and 184 orthologues. Broad expression in testis (RPKM 46.4), colon (RPKM 13.2) and 24 other tissues.

Summary

Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008]

GTF2A2 Products(3)

mRNA Protein Name
NM_001320929.2 NP_001307858.1 transcription initiation factor IIA subunit 2
NM_001320930.2 NP_001307859.1 transcription initiation factor IIA subunit 2
NM_004492.3 NP_004483.1 transcription initiation factor IIA subunit 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA polymerase II general transcription initiation factor activity IDA
IDA: Inferred from direct assay
7958899 GOA
enables RNA polymerase II general transcription initiation factor binding IPI
IPI: Inferred from physical interaction
8626665 GOA
enables TBP-class protein binding IPI
IPI: Inferred from physical interaction
7724559 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7724559 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
8626665 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
8626665 GOA
Biological Process GO Annotation Evidence Reference Source
involved in RNA polymerase II preinitiation complex assembly IDA
IDA: Inferred from direct assay
7958899 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10022900 GOA
involved in positive regulation of transcription initiation by RNA polymerase II IDA
IDA: Inferred from direct assay
11030333 GOA
involved in transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7724559 GOA
involved in transcription initiation at RNA polymerase II promoter IDA
IDA: Inferred from direct assay
7958899 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
10022900 GOA
part of transcription factor TFIIA complex IDA
IDA: Inferred from direct assay
7724559 GOA
part of transcription factor TFIIA complex IPI
IPI: Inferred from physical interaction
8626665 GOA
part of transcription factor TFIID complex IDA
IDA: Inferred from direct assay
27193682 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GTF2A2 Protein Structure

TFIIA_gamma_N

TFIIA_gamma_N: Transcription initiation factor IIA, gamma subunit, helical domain (1 - 49)

TFIIA_gamma_C

TFIIA_gamma_C: Transcription initiation factor IIA, gamma subunit (51 - 100)

  • 0
  • 100
  • 109 a.a.
Protein Preferred Names Protein Names

transcription initiation factor IIA subunit 2

TFIIA gamma subunit

GTF2A2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GTF2A2 P52657 TRIM7 Homo sapiens Q9C029
Y2H Array
32296183
Intra
GTF2A2 P52657 TRIM7 Homo sapiens Q9C029
Validated Y2H
32296183
Intra
GTF2A2 P52657 TRIM7 Homo sapiens Q9C029
Y2H Prey Pooling
32296183
Intra
GTF2A2 P52657 TBP Homo sapiens P20226
Anti Tag CoIP
33961781
Intra
GTF2A2 P52657 TBP Homo sapiens P20226
Pull Down
8626665
Intra
GTF2A2 P52657 TBP Homo sapiens P20226
Pull Down
7724559
Intra
GTF2A2 P52657 GTF2A1 Homo sapiens P52655
Y2H Array
32296183
Intra
GTF2A2 P52657 GTF2A1 Homo sapiens P52655
Anti Tag CoIP
33961781
Intra
GTF2A2 P52657 GTF2A1 Homo sapiens P52655
Y2H Array
31515488
Intra
GTF2A2 P52657 GTF2A1 Homo sapiens P52655
Y2H Prey Pooling
32296183
Intra
GTF2A2 P52657 GTF2A1 Homo sapiens P52655
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05893 GTF2A2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05895 GTF2E2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05897 GTF2F2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05899 GTF2H2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GTF2A2 VGNC VGNC:67492
Bos taurus GTF2A2 VGNC VGNC:29692
Rattus norvegicus GTF2A2 RGD RGD:620720
Macaca mulatta GTF2A2 VGNC VGNC:84345
Canis familiaris GTF2A2 VGNC VGNC:41542
Mus musculus GTF2A2 MGD MGI:1933289