GTF2A1 - general transcription factor IIA subunit 1 Gene

Homo sapiens

Also known as TF2A1; TFIIA; TFIIAL; TFIIA-42

Gene ID: 2957 | Gene type: protein coding

About GTF2A1

Cytogenetic location: 14q31.1 Genomic coordinates (GRCh38): 14:81,175,452-81,221,390 (from NCBI)

This gene has 4 transcripts (splice variants), 213 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 15.3), testis (RPKM 12.9) and 25 other tissues.

Summary

Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010]

GTF2A1 Products(3)

mRNA	Protein	Name
NM_001278940.2	NP_001265869.1	transcription initiation factor IIA subunit 1 isoform 3
NM_015859.4	NP_056943.1	transcription initiation factor IIA subunit 1 isoform 1
NM_201595.3	NP_963889.1	transcription initiation factor IIA subunit 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	7724559	GOA
enables RNA polymerase II core promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	29111974	GOA
enables RNA polymerase II general transcription initiation factor activity	IDA IDA: Inferred from direct assay	27193682	GOA
enables RNA polymerase II general transcription initiation factor binding	IPI IPI: Inferred from physical interaction	8626665	GOA
enables TBP-class protein binding	IPI IPI: Inferred from physical interaction	7724559	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8006019	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	8626665	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10022900	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	11030333	GOA
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7724559	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	10022900	GOA
part of transcription factor TFIIA complex	IDA IDA: Inferred from direct assay	7724559	GOA
part of transcription factor TFIIA complex	IPI IPI: Inferred from physical interaction	8626665	GOA
part of transcription factor TFIID complex	IDA IDA: Inferred from direct assay	27193682	GOA
part of transcription preinitiation complex	IDA IDA: Inferred from direct assay	8224850	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GTF2A1 Protein Structure

TFIIA

0
100
200
300
376 a.a.

Protein Preferred Names

Protein Names

transcription initiation factor IIA subunit 1

TFIIA alpha/beta subunits

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05892	GTF2A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05896	GTF2F1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05898	GTF2H1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05904	GTF2IRD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GTF2A1	MGD	MGI:1933277
Bos taurus	GTF2A1	VGNC	VGNC:29691
Canis familiaris	GTF2A1	VGNC	VGNC:41541
Macaca mulatta	GTF2A1	VGNC	VGNC:73305
Rattus norvegicus	GTF2A1	RGD	RGD:69246
Felis catus	GTF2A1	VGNC	VGNC:104398

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