1. Gene
  2. Pacsin1 - protein kinase C and casein kinase substrate in neurons 1 Gene

Pacsin1 - protein kinase C and casein kinase substrate in neurons 1 Gene

Rattus norvegicus
Gene ID: 29704 | Gene type: protein coding

About Pacsin1

Summary

Enables phospholipid binding activity. Involved in several processes, including plasma membrane tubulation; positive regulation of dendrite development; and regulation of postsynaptic neurotransmitter receptor internalization. Located in axon terminus; perinuclear region of cytoplasm; and plasma membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human PACSIN1 (protein kinase C and Casein Kinase substrate in neurons 1). [provided by Alliance of Genome Resources, Apr 2022]

Pacsin1 Products(1)

mRNA Protein Name
NM_017294.1 NP_058990.1 protein kinase C and casein kinase substrate in neurons protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phospholipid binding IDA
IDA: Inferred from direct assay
22355135 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9950691 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cytoskeleton organization IDA
IDA: Inferred from direct assay
9950691 RGD
involved in neuron projection morphogenesis IMP
IMP: Inferred from mutant phenotype
22355135 RGD
involved in plasma membrane tubulation IMP
IMP: Inferred from mutant phenotype
22355135 RGD
involved in positive regulation of dendrite development IDA
IDA: Inferred from direct assay
21725280 RGD
involved in protein localization to plasma membrane IDA
IDA: Inferred from direct assay
21725280 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
16617342 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
16617342 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axon terminus IDA
IDA: Inferred from direct assay
22355135 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16617342 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
16617342 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
21725280 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
21725280 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
16617342 RGD
located in synapse IDA
IDA: Inferred from direct assay
21725280 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein kinase C and casein kinase substrate in neurons protein 1

dynamin PRD-interacting protein

dynamin proline-rich domain-interacting protein

sdpI

synaptic, dynamin-associated protein I

syndapin-1

syndapin-I

Pacsin1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
Pacsin1 Q9Z0W5 Cobl Mus musculus Q5NBX1
Pull Down
21725280
Cross
Pacsin1 Q9Z0W5 Cobl Mus musculus Q5NBX1
Y2H
17956734
Intra
Pacsin1 Q9Z0W5 Cobl Rattus norvegicus D3ZUI5
Anti Bait CoIP
21725280
Intra
Pacsin1 Q9Z0W5 Cobl Rattus norvegicus D3ZUI5
Density Sedimentation
21725280
Cross
Pacsin1 Q9Z0W5 NCKIPSD Homo sapiens Q9NZQ3
Y2H
16999739
Cross
Pacsin1 Q9Z0W5 NCKIPSD Homo sapiens Q9NZQ3
Anti Bait CoIP
16999739
Cross
Pacsin1 Q9Z0W5 NCKIPSD Homo sapiens Q9NZQ3
Pull Down
16999739
Intra
Pacsin1 Q9Z0W5 Dnm1 Rattus norvegicus P21575
Anti Bait CoIP
17437541
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Homo sapiens Pacsin1 NCBI NCBI:29993