PACSIN1 - protein kinase C and casein kinase substrate in neurons 1 Gene

Homo sapiens

Also known as SDPI

Gene ID: 29993 | Gene type: protein coding

About PACSIN1

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:34,466,076-34,535,223 (from NCBI)

This gene has 7 transcripts (splice variants), 275 orthologues and 2 paralogues. Biased expression in brain (RPKM 42.1) and lymph node (RPKM 1.5).

Summary

Enables phospholipid binding activity. Involved in plasma membrane tubulation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PACSIN1 Products(2)

mRNA	Protein	Name
NM_001199583.3	NP_001186512.1	protein kinase C and casein kinase substrate in neurons protein 1
NM_020804.5	NP_065855.1	protein kinase C and casein kinase substrate in neurons protein 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables phospholipid binding	IDA IDA: Inferred from direct assay	19549836	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in plasma membrane tubulation	IDA IDA: Inferred from direct assay	19549836	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PACSIN1 Protein Structure

FCH

SH3_9

0
100
200
300
400
444 a.a.

Protein Preferred Names

Protein Names

protein kinase C and casein kinase substrate in neurons protein 1

syndapin I

PACSIN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PACSIN1	Q9BY11	SLFN12	Homo sapiens	Q8IYM2	Y2H Pooling	32814053
Intra	PACSIN1	Q9BY11	SLFN12	Homo sapiens	Q8IYM2	Validated Y2H	32814053
Intra	PACSIN1	Q9BY11	SLFN12	Homo sapiens	Q8IYM2	Y2H Array	32814053
Intra	PACSIN1	Q9BY11	COBLL1	Homo sapiens	Q53SF7	Anti Tag CoIP	33961781
Intra	PACSIN1	Q9BY11	COBLL1	Homo sapiens	Q53SF7	Y2H Pooling	20936779
Intra	PACSIN1	Q9BY11	COBL	Homo sapiens	O75128	Y2H Fragment Pooling	31413325
Intra	PACSIN1	Q9BY11	COBL	Homo sapiens	O75128	Anti Tag CoIP	33961781
Intra	PACSIN1	Q9BY11	FASLG	Homo sapiens	P48023	Anti Bait CoIP	16318909
Intra	PACSIN1	Q9BY11	FASLG	Homo sapiens	P48023	Anti Tag CoIP	16318909
Intra	PACSIN1	Q9BY11	FASLG	Homo sapiens	P48023	Pull Down	16318909
Intra	PACSIN1	Q9BY11	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	PACSIN1	Q9BY11	PACSIN2	Homo sapiens	Q9UNF0	Anti Tag CoIP	33961781
Intra	PACSIN1	Q9BY11	PACSIN2	Homo sapiens	Q9UNF0	Validated Y2H	25416956
Intra	PACSIN1	Q9BY11	PACSIN2	Homo sapiens	Q9UNF0	Validated Y2H	32296183
Intra	PACSIN1	Q9BY11	PACSIN2	Homo sapiens	Q9UNF0	Y2H Array	25416956
Intra	PACSIN1	Q9BY11	PACSIN2	Homo sapiens	Q9UNF0	Y2H Pooling	20936779
Intra	PACSIN1	Q9BY11	PACSIN2	Homo sapiens	Q9UNF0	Y2H Fragment Pooling	31413325
Intra	PACSIN1	Q9BY11	PACSIN2	Homo sapiens	Q9UNF0	Y2H Prey Pooling	25416956
Intra	PACSIN1	Q9BY11	POT1	Homo sapiens	Q9NUX5	Pull Down	21044950
Intra	PACSIN1	Q9BY11	PACSIN3	Homo sapiens	Q9UKS6	Anti Tag CoIP	33961781
Intra	PACSIN1	Q9BY11	PACSIN3	Homo sapiens	Q9UKS6	Anti Tag CoIP	28514442
Intra	PACSIN1	Q9BY11	PACSIN3	Homo sapiens	Q9UKS6	Y2H Array	31515488
Intra	PACSIN1	Q9BY11	PACSIN3	Homo sapiens	Q9UKS6	Y2H Prey Pooling	25416956
Intra	PACSIN1	Q9BY11	PACSIN3	Homo sapiens	Q9UKS6	Validated Y2H	32296183
Intra	PACSIN1	Q9BY11	PACSIN3	Homo sapiens	Q9UKS6	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PACSIN1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71183	PACSIN1 Protein, Human (HEK293, His)	Q9BY11 (M1-I444)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09957	PACSIN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PACSIN1	VGNC	VGNC:44231
Rattus norvegicus	PACSIN1	RGD	RGD:3247
Felis catus	PACSIN1	VGNC	VGNC:68681
Macaca mulatta	PACSIN1	VGNC	VGNC:75744
Bos taurus	PACSIN1	VGNC	VGNC:32542
Mus musculus	PACSIN1	MGD	MGI:1345181
Others	PACSIN1	NCBI

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