Ywhae - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon Gene

Rattus norvegicus

Also known as 14-3-3e

Gene ID: 29753 | Gene type: protein coding

About Ywhae

Summary

Enables Enzyme binding activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Located in central region of growth cone and cytosol. Part of Kinesin complex. Is active in glutamatergic synapse. Orthologous to human YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon). [provided by Alliance of Genome Resources, Apr 2022]

Ywhae Products(1)

mRNA	Protein	Name
NM_031603.2	NP_113791.2	14-3-3 protein epsilon

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	8694795	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16679322	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	17202468	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	EXP EXP: Inferred from Experiment	19477150	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA IDA: Inferred from direct assay	19477150	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	17202468	RGD
located in central region of growth cone	IDA IDA: Inferred from direct assay	17202468	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	19477150	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19477150	RGD
part of kinesin complex	IDA IDA: Inferred from direct assay	17202468	RGD
is active in synapse	IDA IDA: Inferred from direct assay	7964746	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

14-3-3 protein epsilon

14-3-3 epsilon	MSF L
mitochondrial import stimulation factor (MSF) L subunit	mitochondrial import stimulation factor L subunit
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	tyrosine 3-monooxygenase/trypto

Ywhae Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Ywhae	P62260	FBXO4	Homo sapiens	Q9UKT5	Pull Down	21242966

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15941	YWHAE Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ywhae	NCBI	NCBI:7531
Mus musculus	Ywhae	NCBI	NCBI:22627

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