FBXO4 - F-box protein 4 Gene

Homo sapiens

Also known as FBX4

Gene ID: 26272 | Gene type: protein coding

About FBXO4

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:41,925,281-42,040,404 (from NCBI)

This gene has 7 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in thyroid (RPKM 3.2), lymph node (RPKM 2.5) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

FBXO4 Products(3)

mRNA	Protein	Name
NM_001297437.2	NP_001284366.1	F-box only protein 4 isoform 3
NM_012176.3	NP_036308.1	F-box only protein 4 isoform 1
NM_033484.3	NP_277019.1	F-box only protein 4 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16275645	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	20181953	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	29142209	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	10531035	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	20159592	GOA
involved in positive regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	16275645	GOA
involved in positive regulation of telomere maintenance via telomerase	IMP IMP: Inferred from mutant phenotype	16275645	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	16275645	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	10531035	GOA
involved in regulation of protein stability	IDA IDA: Inferred from direct assay	24389012	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	16275645	GOA
involved in telomere maintenance	IMP IMP: Inferred from mutant phenotype	16275645	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	16275645	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	20181953	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21378169	GOA
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	10531035	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO4 Protein Structure

F-box

0
100
200
300
387 a.a.

Protein Preferred Names

Protein Names

F-box only protein 4

F-box protein Fbx4

FBXO4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FBXO4	Q9UKT5	SKP1	Homo sapiens	P63208	Anti Bait CoIP	21242966
Intra	FBXO4	Q9UKT5	SKP1	Homo sapiens	P63208	Y2H Array	32296183
Intra	FBXO4	Q9UKT5	SKP1	Homo sapiens	P63208	Anti Tag CoIP	28514442
Intra	FBXO4	Q9UKT5	SKP1	Homo sapiens	P63208	Anti Tag CoIP	16278047
Intra	FBXO4	Q9UKT5	SKP1	Homo sapiens	P63208	Y2H Prey Pooling	32296183
Intra	FBXO4	Q9UKT5	YWHAE	Homo sapiens	P62258	Anti Bait CoIP	21242966
Intra	FBXO4	Q9UKT5	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	21242966
Intra	FBXO4	Q9UKT5	CUL1	Homo sapiens	Q13616	Anti Bait CoIP	17353931
Intra	FBXO4	Q9UKT5	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	33961781
Intra	FBXO4	Q9UKT5	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	16278047
Intra	FBXO4	Q9UKT5	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	28514442
Intra	FBXO4	Q9UKT5	TNNI3K	Homo sapiens	Q59H18	Y2H Array	32296183
Intra	FBXO4	Q9UKT5	TNNI3K	Homo sapiens	Q59H18	Y2H Prey Pooling	32296183
Intra	FBXO4	Q9UKT5	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	FBXO4	Q9UKT5	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	FBXO4	Q9UKT5	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Cross	FBXO4	Q9UKT5	Ywhae	Rattus norvegicus	P62260	Anti Tag CoIP	21242966

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Dyskeratosis Congenita, Autosomal Dominant 3

DKCA3	Autosomal Dominant Dyskeratosis Congenita 3
Dyskeratosis Congenita, Autosomal Dominant, 3	Dyskeratosis Congenita, Autosomal Dominant, Type 3

Dyskeratosis Congenita, Autosomal Recessive 6

DKCB6	Autosomal Recessive Dyskeratosis Congenita 6
Dyskeratosis Congenita, Autosomal Recessive, 6	Dyskeratosis Congenita, Autosomal Recessive, Type 6

Dyskeratosis Congenita, Autosomal Recessive 1

DKCB1	Autosomal Recessive Dyskeratosis Congenita 1
Dyskeratosis Congenita, Autosomal Recessive, 1	Dyskeratosis Congenita, Autosomal Recessive, Type 1

Dyskeratosis Congenita, Autosomal Recessive 3

DKCB3	Autosomal Recessive Dyskeratosis Congenita 3
Dyskeratosis Congenita, Autosomal Recessive, 3	Dyskeratosis Congenita, Autosomal Recessive, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04806	FBXO4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FBXO4	MGD	MGI:2146220
Felis catus	FBXO4	VGNC	VGNC:62191
Canis familiaris	FBXO4	VGNC	VGNC:40779
Bos taurus	FBXO4	VGNC	VGNC:28910
Rattus norvegicus	FBXO4	RGD	RGD:1307580
Macaca mulatta	FBXO4	VGNC	VGNC:72488
Others	FBXO4	NCBI

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