PRDM14 - PR/SET domain 14 Gene

Homo sapiens

Also known as PFM11

Gene ID: 63978 | Gene type: protein coding

About PRDM14

Cytogenetic location: 8q13.3 Genomic coordinates (GRCh38): 8:70,051,651-70,071,252 (from NCBI)

This gene has 2 transcripts (splice variants), 195 orthologues and 36 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess Histone Methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast Cancer. [provided by RefSeq, Dec 2011]

PRDM14 Products(1)

mRNA	Protein	Name
NM_024504.4	NP_078780.1	PR domain zinc finger protein 14

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20211142	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRDM14 Protein Structure

SET

zf-C2H2_4

zf-H2C2_2

zf-C2H2

0
100
200
300
400
500
571 a.a.

Protein Preferred Names

Protein Names

PR domain zinc finger protein 14

PR domain 14

PRDM14 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRDM14	Q9GZV8	RUNX1T1	Homo sapiens	Q06455-4	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	RUNX1T1	Homo sapiens	Q06455-4	Validated Y2H	25416956
Intra	PRDM14	Q9GZV8	RUNX1T1	Homo sapiens	Q06455-4	Y2H Array	25416956
Intra	PRDM14	Q9GZV8	MIA3	Homo sapiens	Q5JRA6-2	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	MIA3	Homo sapiens	Q5JRA6-2	Validated Y2H	25416956
Intra	PRDM14	Q9GZV8	RAD51D	Homo sapiens	O75771	Y2H Array	25416956
Intra	PRDM14	Q9GZV8	RAD51D	Homo sapiens	O75771	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	PATZ1	Homo sapiens	Q9HBE1-4	Validated Y2H	32296183
Intra	PRDM14	Q9GZV8	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	PRDM14	Q9GZV8	CBFA2T2	Homo sapiens	O43439-4	Anti Tag CoIP	28514442
Intra	PRDM14	Q9GZV8	GPATCH2L	Homo sapiens	Q9NWQ4-1	Validated Y2H	32296183
Intra	PRDM14	Q9GZV8	TCAF1	Homo sapiens	Q9Y4C2-2	Validated Y2H	32296183
Intra	PRDM14	Q9GZV8	RUNX1T1	Homo sapiens	Q06455-2	Anti Tag CoIP	28514442
Intra	PRDM14	Q9GZV8	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	PSMA1	Homo sapiens	P25786	Y2H Array	25416956
Intra	PRDM14	Q9GZV8	PSMA1	Homo sapiens	P25786	Validated Y2H	25416956
Cross	PRDM14	Q9GZV8	Hoxa1	Mus musculus	P09022	Y2H	23088713
Intra	PRDM14	Q9GZV8	EIF4E2	Homo sapiens	O60573	Y2H Array	25416956
Intra	PRDM14	Q9GZV8	HEXIM2	Homo sapiens	Q96MH2	Y2H	21516116
Intra	PRDM14	Q9GZV8	HEXIM2	Homo sapiens	Q96MH2	Y2H Array	25416956
Intra	PRDM14	Q9GZV8	GPATCH2L	Homo sapiens	Q9NWQ4	Y2H Array	25416956
Intra	PRDM14	Q9GZV8	GPATCH2L	Homo sapiens	Q9NWQ4	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	ZNF835	Homo sapiens	Q9Y2P0	Validated Y2H	32296183
Intra	PRDM14	Q9GZV8	HSPB7	Homo sapiens	Q9UBY9	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	HSPB7	Homo sapiens	Q9UBY9	Y2H Array	25416956
Intra	PRDM14	Q9GZV8	RUNX1T1	Homo sapiens	Q06455	Anti Tag CoIP	33961781
Intra	PRDM14	Q9GZV8	RCOR3	Homo sapiens	Q9P2K3	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	PRDM14	Q9GZV8	BEX2	Homo sapiens	Q9BXY8	Y2H Array	25416956
Intra	PRDM14	Q9GZV8	BEX2	Homo sapiens	Q9BXY8	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	CBFA2T2	Homo sapiens	O43439	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	CBFA2T2	Homo sapiens	O43439	MAPPIT	25416956
Intra	PRDM14	Q9GZV8	CBFA2T2	Homo sapiens	O43439	Anti Tag CoIP	25416956
Intra	PRDM14	Q9GZV8	CBFA2T2	Homo sapiens	O43439	Anti Bait CoIP	27281218
Intra	PRDM14	Q9GZV8	CBFA2T2	Homo sapiens	O43439	GMS	27281218
Intra	PRDM14	Q9GZV8	CBFA2T2	Homo sapiens	O43439	Y2H Array	25416956
Intra	PRDM14	Q9GZV8	CBFA2T2	Homo sapiens	O43439	Anti Tag CoIP	33961781
Intra	PRDM14	Q9GZV8	CBFA2T2	Homo sapiens	O43439	Anti Tag CoIP	27281218
Intra	PRDM14	Q9GZV8	TEKT4	Homo sapiens	Q8WW24	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	TTC32	Homo sapiens	Q5I0X7	Validated Y2H	25416956
Intra	PRDM14	Q9GZV8	TTC32	Homo sapiens	Q5I0X7	Y2H Array	25416956
Intra	PRDM14	Q9GZV8	TTC32	Homo sapiens	Q5I0X7	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	DMRT3	Homo sapiens	Q9NQL9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Malignant Pineal Area Germ Cell Neoplasm

Pineal Germ Cell Tumor	Malignant Pineal Parenchymal Germ Cell Tumor
Pineal Region Germ Cell Tumor	Pineal Cell Tumor
Pineal Cell Tumour	Pineal Region Germinoma
Malignant Pineal Region Germ Cell Tumor	Pineal Germinoma

Brain Germinoma

Intracranial Germinoma

Germinoma Of The Brain

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Pineal Region Germinoma

Pineal Germinoma

Malignant Teratoma

Immature Teratoma	Malignant Extragonadal Teratoma
Primary Malignant Extragonadal Teratoma	Teratoma, Malignant, Nos
Teratoma, Malignant	Immature Extragonadal Teratoma

Testicular Germ Cell Cancer

Germ Cell Tumor Of Testis	Testicular Germ Cell Tumor
Testicular Germ Cell Neoplasm	Testicular Malignant Germ Cell Tumor

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11064	PRDM14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PRDM14	VGNC	VGNC:44946
Rattus norvegicus	PRDM14	RGD	RGD:2319590
Mus musculus	PRDM14	MGD	MGI:3588194
Bos taurus	PRDM14	VGNC	VGNC:33292
Felis catus	PRDM14	VGNC	VGNC:64345
Macaca mulatta	PRDM14	VGNC	VGNC:104473

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