SNX10 - sorting nexin 10 Gene

Homo sapiens

Also known as OPTB8

Gene ID: 29887 | Gene type: protein coding

About SNX10

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:26,291,862-26,374,383 (from NCBI)

This gene has 27 transcripts (splice variants), 278 orthologues, 15 paralogues and is associated with 2 phenotypes. Broad expression in brain (RPKM 20.5), appendix (RPKM 13.4) and 19 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

SNX10 Products(8)

mRNA	Protein	Name
NM_001199835.1	NP_001186764.1	sorting nexin-10 isoform 1
NM_001199837.3	NP_001186766.1	sorting nexin-10 isoform 2
NM_001199838.2	NP_001186767.1	sorting nexin-10 isoform 3
NM_001318198.1	NP_001305127.1	sorting nexin-10 isoform 4
NM_001318199.3	NP_001305128.1	sorting nexin-10 isoform 1
NM_001362753.1	NP_001349682.1	sorting nexin-10 isoform 4
NM_001362754.1	NP_001349683.1	sorting nexin-10 isoform 4
NM_013322.3	NP_037454.2	sorting nexin-10 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-phosphatidylinositol binding	IMP IMP: Inferred from mutant phenotype	17012226	GOA
enables ATPase binding	IPI IPI: Inferred from physical interaction	21844891	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	21844891	GOA
involved in endosome organization	IMP IMP: Inferred from mutant phenotype	17012226	GOA
involved in protein localization to centrosome	IMP IMP: Inferred from mutant phenotype	21844891	GOA
involved in protein localization to cilium	IMP IMP: Inferred from mutant phenotype	21844891	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with centrosome	IDA IDA: Inferred from direct assay	21844891	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	22174188	GOA
located in extrinsic component of endosome membrane	IDA IDA: Inferred from direct assay	17012226	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22174188	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX10 Protein Structure

0
100
201 a.a.

Protein Preferred Names

Protein Names

sorting nexin-10

SNX10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SNX10	Q9Y5X0	PRKCA	Homo sapiens	P17252	Validated Y2H	32814053
Intra	SNX10	Q9Y5X0	PRKCA	Homo sapiens	P17252	Y2H Array	32814053
Intra	SNX10	Q9Y5X0	PRKCA	Homo sapiens	P17252	Y2H Pooling	32814053
Intra	SNX10	Q9Y5X0	YIF1A	Homo sapiens	O95070	Y2H Array	32296183
Intra	SNX10	Q9Y5X0	YIF1A	Homo sapiens	O95070	Y2H Prey Pooling	32296183
Intra	SNX10	Q9Y5X0	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	SNX10	Q9Y5X0	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	SNX10	Q9Y5X0	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	SNX10	Q9Y5X0	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	SNX10	Q9Y5X0	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	SNX10	Q9Y5X0	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	SNX10	Q9Y5X0	RABAC1	Homo sapiens	Q9UI14	Y2H Prey Pooling	32296183
Intra	SNX10	Q9Y5X0	RABAC1	Homo sapiens	Q9UI14	Y2H Array	32296183
Intra	SNX10	Q9Y5X0	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	32296183
Intra	SNX10	Q9Y5X0	ARL6IP1	Homo sapiens	Q15041	Y2H Array	32296183
Intra	SNX10	Q9Y5X0	ARL6IP1	Homo sapiens	Q15041	Validated Y2H	25416956
Intra	SNX10	Q9Y5X0	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	SNX10	Q9Y5X0	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	SNX10	Q9Y5X0	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Osteopetrosis, Autosomal Recessive 8

Autosomal Recessive Osteopetrosis 8	OPTB8
Osteopetrosis, Autosomal Recessive, Type 8

Autosomal Recessive Malignant Osteopetrosis

Infantile Malignant Osteopetrosis

Osteopetrosis

Marble Bone Disease	Albers-Schonberg Disease
Osteopetroses	Marble Bones
Osteopetrosis And Related Disorders	Congenital Osteopetrosis
Marble Bone	Albers-Schoenberg Disease
Albers-Schonberg Osteopetrosis	Osteosclerosis Fragilis
Ivory Bones

Osteopetrosis, Autosomal Recessive 2

OPTB2	Autosomal Recessive Osteopetrosis 2
Osteopetrosis, Mild Autosomal Recessive Form	Osteoclast-Poor Osteopetrosis
Osteopetrosis, Osteoclast-Poor	Mild Autosomal Recessive Form Osteopetrosis
Osteopetrosis Autosomal Recessive 2	Autosomal Recessive Osteopetrosis Type 2
Osteopetrosis Osteoclast-Poor	Osteopetrosis, Autosomal Recessive, Type 2

Pycnodysostosis

Pyknodysostosis	PKND
Pycd	Toulouse-Lautrec Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160477	DC-SX029	Inhibitor	98.07%	Unkown
HY-RS13523	SNX10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SNX10	VGNC	VGNC:77705
Bos taurus	SNX10	VGNC	VGNC:35091
Mus musculus	SNX10	MGD	MGI:1919232
Felis catus	SNX10	VGNC	VGNC:102706
Rattus norvegicus	SNX10	RGD	RGD:1305782
Canis familiaris	SNX10	VGNC	VGNC:46620

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