CPSF1 - cleavage and polyadenylation specific factor 1 Gene

Homo sapiens

Also known as MYP27; CPSF160; P/cl.18; HSU37012

Gene ID: 29894 | Gene type: protein coding

About CPSF1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,393,231-144,409,335 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 197 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 31.8), duodenum (RPKM 25.9) and 25 other tissues.

Summary

Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]

CPSF1 Products(1)

mRNA	Protein	Name
NM_013291.3	NP_037423.2	cleavage and polyadenylation specificity factor subunit 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	7590244	GOA
enables mRNA 3'-UTR AU-rich region binding	IDA IDA: Inferred from direct assay	7590244	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7590244	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of mRNA cleavage and polyadenylation specificity factor complex	IDA IDA: Inferred from direct assay	7590244	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPSF1 Protein Structure

MMS1_N

CPSF_A

0
300
600
900
1200
1443 a.a.

Protein Preferred Names

Protein Names

cleavage and polyadenylation specificity factor subunit 1

CPSF 160 kDa subunit

Related Diseases

Diseases

Alias

Myopia 27, Autosomal Dominant

Myopia 27

MYP27

Refractive Error

Refractive Errors

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Oculopharyngeal Muscular Dystrophy

OPMD	Muscular Dystrophy, Oculopharyngeal
Dystrophy, Oculopharyngeal Muscular	Oculopharyngeal Dystrophy
Progressive Muscular Dystrophy, Oculopharyngeal Type	Muscular Dystrophy Oculopharyngeal
Dystrophy, Muscular, Oculopharyngeal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03116	CPSF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CPSF1	VGNC	VGNC:39573
Rattus norvegicus	CPSF1	RGD	RGD:1306406
Macaca mulatta	CPSF1	VGNC	VGNC:71472
Bos taurus	CPSF1	VGNC	VGNC:27670
Felis catus	CPSF1	VGNC	VGNC:82368
Mus musculus	CPSF1	MGD	MGI:2679722

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