2. Gene
  3. H1-0 - H1.0 linker histone Gene

H1-0 - H1.0 linker histone Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as H10; H1.0; H1F0; H1FV

Gene ID: 3005 | Gene type: protein coding

About H1-0

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,805,229-37,807,432 (from NCBI)

This gene has 1 transcript (splice variant), 201 orthologues and 9 paralogues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]

H1-0 Products(1)

mRNA Protein Name
NM_005318.4 NP_005309.1 histone H1.0
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
15911621 GOA
enables nucleosome binding IPI
IPI: Inferred from physical interaction
35377618 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9499053 GOA
Biological Process GO Annotation Evidence Reference Source
involved in heterochromatin formation IGI
IGI: Inferred from genetic interaction
19158276 GOA
involved in positive regulation of transcription regulatory region DNA binding IMP
IMP: Inferred from mutant phenotype
19158276 GOA
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
19882353 GOA
located in euchromatin IDA
IDA: Inferred from direct assay
15911621 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21383955 GOA
part of transcription repressor complex IDA
IDA: Inferred from direct assay
19158276 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H1-0 Protein Structure

Linker_histone

Linker_histone: linker histone H1 and H5 family (25 - 97)

  • 0
  • 100
  • 194 a.a.
Protein Preferred Names Protein Names

histone H1.0

H1 histone family member 0

H1-0 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
H1-0 P07305 H2BC21 Homo sapiens Q16778
Anti Tag CoIP
35271311
Intra
H1-0 P07305 H2BC21 Homo sapiens Q16778
Crosslink
30021884
Intra
H1-0 P07305 H2AC21 Homo sapiens Q8IUE6
Anti Tag CoIP
35271311
Intra
H1-0 P07305 H2AC14 Homo sapiens Q99878
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant H1-0 Proteins

Cat. No. Product Name Accession Purity
HY-P74887 Histone H1 Protein, Human (His) P07305-1 (M1-K194) ≥95%

Related Diseases

Diseases Alias
Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1

HP1

Glycolic Aciduria

Alanine-Glyoxylate Aminotransferase Deficiency

Hepatic Agt Deficiency

Oxalosis I

Primary Hyperoxaluria, Type I

Serine:Pyruvate Aminotransferase Deficiency

Hyperoxaluria, Primary, Type 1

Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency

Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency

Serine Pyruvate Aminotransferase Deficiency

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Oxalosis 1

Hyperoxaluria Primary 1

Hyperoxaluria Primary Type I

Ph1

Primary Hyperoxaluria Type I

Oxalosis Type 1

2-Oxoglutarate Glyoxylate Carboligase Deficiency
Primary Hyperoxaluria

Hyperoxaluria

Hyperoxaluria, Primary

Oxalosis

Primary Oxalosis

Congenital Oxaluria

D-Glycerate Dehydrogenase Deficiency

Glyceric Aciduria

Glycolic Aciduria

Hepatic Agt Deficiency

Oxaluria, Primary

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Primary Oxaluria

Hyperoxaluria Primary

Primary Hyperoxaluria Type 2

Primary Hyperoxaluria, Type I
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Alpha-Thalassemia

Alpha Thalassemia

Alpha Thalassaemia

Alpha Plus Thalassemia

Thalassemia, Alpha-

Thalassemias, Alpha-

A-Thalassemia

Α-Thalassemia

A-THAL

Thalassemia

Alpha Thalassaemia Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P5831 Biotin-H10 Inhibitor 98.04% Unkown
HY-117889 PARP14 inhibitor H10 98.04% Unkown
HY-162630 HDAC6-IN-44 Inhibitor / Unkown
HY-RS05944 H1-0 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus H1-0 VGNC VGNC:84027
Mus musculus H1-0 MGD MGI:95893
Rattus norvegicus H1-0 RGD RGD:2777
Bos taurus H1-0 VGNC VGNC:83619
Macaca mulatta H1-0 VGNC VGNC:109666
Others H1-0 NCBI