Myd88 - MYD88, innate immune signal transduction adaptor Gene

Rattus norvegicus

Gene ID: 301059 | Gene type: protein coding

About Myd88

Primary_assembly 8: 119,074,437-119,079,415 reverse strand.mRatBN7.2:CM026981.1

This gene has 4 transcripts (splice variants), 200 orthologues and is associated with 61 phenotypes. Biased expression in Spleen (RPKM 125.3), Thymus (RPKM 16.6) and 9 other tissues.

Summary

Enables Toll binding activity and interleukin-1 receptor binding activity. Involved in JNK cascade; cell surface receptor signaling pathway; and positive regulation of smooth muscle cell proliferation. Located in postsynaptic density. Part of protein-containing complex. Human ortholog(s) of this gene implicated in Waldenstroem's macroglobulinemia; colorectal carcinoma; and primary immunodeficiency disease. Orthologous to human MyD88 (MyD88 innate immune signal transduction adaptor). [provided by Alliance of Genome Resources, Apr 2022]

Myd88 Products(1)

mRNA	Protein	Name
NM_198130.2	NP_937763.2	myeloid differentiation primary response protein MyD88

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Toll binding	IDA IDA: Inferred from direct assay	14962484	RGD
enables interleukin-1 receptor binding	IPI IPI: Inferred from physical interaction	21314939	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19144836	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	14962484	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in JNK cascade	IMP IMP: Inferred from mutant phenotype	15890643	RGD
involved in Toll signaling pathway	IDA IDA: Inferred from direct assay	14962484	RGD
involved in cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	15890643	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	15890643	RGD
involved in response to amine	IEP IEP: Inferred from expression pattern	31068809	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	21276439	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	21276439	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	33575076	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	21314939	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Myd88 Protein Structure

Death_MyD88

TIR

0
100
200
296 a.a.

Protein Preferred Names

Protein Names

myeloid differentiation primary response protein MyD88

myeloid differentiation primary response 88

myeloid differentiation primary response gene 88

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112137	Trehalose-6,6'-dibehenate		≥98.0%	Phase 3
HY-135317	Emavusertib	Inhibitor	99.96%	Phase 2
HY-135317B	Emavusertib hydrochloride	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (28)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139397	TJ-M2010-5	Inhibitor	99.85%	Unkown
HY-50937	ST 2825	Inhibitor	99.92%	Unkown
HY-110204	Heclin		98.21%	Unkown
HY-N0703	Schaftoside	Inhibitor	99.67%	Unkown
HY-19744	T6167923	Inhibitor	99.40%	Unkown
HY-149992	MyD88-IN-1	Inhibitor	99.95%	Unkown
HY-110195	Smurf1-IN-A01		99.81%	Unkown
HY-Y1881B	Copper sulfate pentahydrate, for cell culture, 98%	Inhibitor	98.00%	Unkown
HY-18976	UF010		99.84%	Unkown
HY-Y0278	Chloranil	Inducer	98%	Unkown
HY-W011400	TLR1		99.43%	Unkown
HY-W014223	2,4′-Dihydroxybenzophenone	Inhibitor	98.00%	Unkown
HY-P10719A	Pepinh-MYD TFA	Inhibitor	/	Unkown
HY-N3979	Grossamide	Inhibitor	/	Unkown
HY-W097625	6-Methoxyflavone	Inhibitor	99.87%	Unkown
HY-163775	Anti-inflammatory agent 88	Agonist	/	Unkown
HY-RS08888	Myd88 Rat Pre-designed siRNA Set A	Inhibitor	/	Unkown
HY-P10719	Pepinh-MYD	Inhibitor	/	Unkown
HY-170446	MyD88-IN-2	Inhibitor	/	Unkown
HY-RS08886	MYD88 Human Pre-designed siRNA Set A	Inhibitor	/	Unkown
HY-RS08887	Myd88 Mouse Pre-designed siRNA Set A	Inhibitor	/	Unkown
HY-173063	TLR8 antagonist-1	Inhibitor	/	Unkown
HY-P10178	Myristoylated ARF6 (2-13)	Inhibitor	/	Unkown
HY-135317D	Emavusertib mesylate	Inhibitor	/	Unkown
HY-135317C	Emavusertib tosylate	Inhibitor	/	Unkown
HY-135317E	Emavusertib maleate	Inhibitor	/	Unkown
HY-135317F	Emavusertib phosphate	Inhibitor	/	Unkown
HY-Y0278R	Chloranil (Standard)	Inducer	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myd88	NCBI	NCBI:4615

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