H2AC8 - H2A clustered histone 8 Gene

Homo sapiens (human)

Also known as H2A.1; H2A.2; H2A/a; H2AC4; H2AFA; HIST1H2AE

Gene ID: 3012 | Gene type: protein coding

About H2AC8

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

H2AC8 Products(1)

mRNA	Protein	Name
NM_021052.4	NP_066390.1	histone H2A type 1-B/E

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20498094	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	23956221	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CENP-A containing nucleosome	IPI IPI: Inferred from physical interaction	21743476	GOA
part of nucleosome	IPI IPI: Inferred from physical interaction	20498094	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16319397	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

histone H2A type 1-B/E

H2A histone family, member A	histone 1, H2ae
histone H2A/a	histone H2AE
histone cluster 1 H2A family member e	histone cluster 1, H2ae

H2AC8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	H2AC4	P04908	H2BC15	Homo sapiens	U3KQK0	Y2H Array	32296183
Intra	H2AC4	P04908	H2BC15	Homo sapiens	U3KQK0	Y2H Prey Pooling	32296183
Intra	H2AC4	P04908	H2BC15	Homo sapiens	U3KQK0	Validated Y2H	32296183
Intra	H2AC4	P04908	H4C16	Homo sapiens	P62805	Anti Tag CoIP	33961781
Intra	H2AC4	P04908	H4C16	Homo sapiens	P62805	3D-EM	31142837
Intra	H2AC4	P04908	H4C16	Homo sapiens	P62805	X-Ray Diffraction	21743476
Intra	H2AC4	P04908	H4C16	Homo sapiens	P62805	SAXS	21743476
Intra	H2AC4	P04908	H4C16	Homo sapiens	P62805	X-Ray Diffraction	20498094
Intra	H2AC4	P04908	H4C16	Homo sapiens	P62805	Comig Non-Denat Gel	21743476
Intra	H2AC4	P04908	H4C16	Homo sapiens	P62805	GMS	20498094
Intra	H2AC4	P04908	H3-4	Homo sapiens	Q16695	X-Ray Diffraction	20498094
Intra	H2AC4	P04908	H2BC11	Homo sapiens	P06899	X-Ray Diffraction	20498094
Intra	H2AC4	P04908	H2BC11	Homo sapiens	P06899	Comig Non-Denat Gel	21743476
Intra	H2AC4	P04908	H2BC11	Homo sapiens	P06899	GMS	20498094
Intra	H2AC4	P04908	H2BC11	Homo sapiens	P06899	Anti Tag CoIP	33961781
Intra	H2AC4	P04908	H2BC11	Homo sapiens	P06899	3D-EM	31142837
Intra	H2AC4	P04908	H2BC11	Homo sapiens	P06899	X-Ray Diffraction	21743476
Intra	H2AC4	P04908	H2BC11	Homo sapiens	P06899	SAXS	21743476

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant H2AC8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72328	H2AC4 Protein, Human	P04908 (S2-K130)	≥95%

H2AC8 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83299	Acetyl-Histone H2A Antibody (YA3044)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P83587	Hydroxyl-Histone H2A Antibody (YA3332)	WB, IHC-P	Human, Mouse

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