H3-4 - H3.4 histone, cluster member Gene

Homo sapiens

Also known as H3t; H3.4; H3/g; H3FT; H3C16; HIST3H3

Gene ID: 8290 | Gene type: protein coding

About H3-4

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:228,424,845-228,425,360 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 115 orthologues, 20 paralogues and is associated with 1 phenotype.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the Other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

H3-4 Products(1)

mRNA	Protein	Name
NM_003493.3	NP_003484.1	histone H3.1t

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17537733	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in nucleosome assembly	IDA IDA: Inferred from direct assay	25615412	GOA
involved in nucleosome assembly	IMP IMP: Inferred from mutant phenotype	20498094	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of nucleosome	IDA IDA: Inferred from direct assay	20498094	GOA
part of nucleosome	IPI IPI: Inferred from physical interaction	20498094	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H3-4 Protein Structure

Histone

0
100
136 a.a.

Protein Preferred Names

Protein Names

histone H3.1t

H3 clustered histone 16

H3-4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	H3-4	Q16695	H4C16	Homo sapiens	P62805	GMS	20498094
Intra	H3-4	Q16695	H4C16	Homo sapiens	P62805	DLS	20498094
Intra	H3-4	Q16695	H2AC4	Homo sapiens	P04908	Crosslink	30021884
Intra	H3-4	Q16695	H2AX	Homo sapiens	P16104	Crosslink	30021884
Intra	H3-4	Q16695	AURKB	Homo sapiens	Q96GD4	Protein Kinase Assay	29340707
Intra	H3-4	Q16695	AURKB	Homo sapiens	Q96GD4	Anti Bait CoIP	29340707
Intra	H3-4	Q16695	NASP	Homo sapiens	P49321-2	Y2H Prey Pooling	32296183
Intra	H3-4	Q16695	NASP	Homo sapiens	P49321-2	Y2H Array	32296183
Intra	H3-4	Q16695	H3C13	Homo sapiens	Q71DI3	Crosslink	30021884
Intra	H3-4	Q16695	CBX5	Homo sapiens	P45973	Crosslink	30021884

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Colon Leiomyoma

Colonic Leiomyoma

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05963	H3-4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	H3-4	RGD	RGD:1583877
Macaca mulatta	H3-4	VGNC	VGNC:109730
Mus musculus	H3-4	MGD	MGI:3651326

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