2. Gene
  3. HBZ - hemoglobin subunit zeta Gene

HBZ - hemoglobin subunit zeta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HBAZ; HBZ1; HBZ-T1

Gene ID: 3050 | Gene type: protein coding

About HBZ

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:152,644-154,503 (from NCBI)

This gene has 2 transcripts (splice variants), 143 orthologues and 11 paralogues. Biased expression in testis (RPKM 1.3), bone marrow (RPKM 0.5) and 1 other tissue.

Summary

Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'. [provided by RefSeq, Nov 2009]

HBZ Products(1)

mRNA Protein Name
NM_005332.3 NP_005323.1 hemoglobin subunit zeta
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
6683087 GOA
Biological Process GO Annotation Evidence Reference Source
involved in oxygen transport IDA
IDA: Inferred from direct assay
7543751 GOA
Cellular Component GO Annotation Evidence Reference Source
part of hemoglobin complex IPI
IPI: Inferred from physical interaction
6683087 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HBZ Protein Structure

Globin

Globin: Globin (8 - 107)

  • 0
  • 100
  • 142 a.a.
Protein Preferred Names Protein Names

hemoglobin subunit zeta

hemoglobin zeta chain

HBZ Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
HBZ P02008 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
HBZ P02008 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra
HBZ P02008 KRTAP10-9 Homo sapiens P60411
Y2H Array
25416956
Intra
HBZ P02008 KRTAP10-7 Homo sapiens P60409
Y2H Array
25416956
Intra
HBZ P02008 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra
HBZ P02008 DOCK8 Homo sapiens Q8NF50-2
Y2H Prey Pooling
25416956
Intra
HBZ P02008 HBQ1 Homo sapiens P09105
Y2H Prey Pooling
32296183
Intra
HBZ P02008 HBQ1 Homo sapiens P09105
Validated Y2H
32296183
Intra
HBZ P02008 HBQ1 Homo sapiens P09105
Y2H Array
32296183
Intra
HBZ P02008 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
HBZ P02008 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
Intra
HBZ P02008 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
HBZ P02008 RBMY1A1 Homo sapiens P0DJD3-2
Validated Y2H
32296183
Intra
HBZ P02008 RBMY1A1 Homo sapiens P0DJD3-2
Y2H Prey Pooling
32296183
Intra
HBZ P02008 HBM Homo sapiens Q6B0K9
Validated Y2H
32296183
Intra
HBZ P02008 NOTCH2NLC Homo sapiens P0DPK4
Validated Y2H
32296183
Intra
HBZ P02008 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
HBZ P02008 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
HBZ P02008 CARD10 Homo sapiens Q9BWT7
Y2H Prey Pooling
32296183
Intra
HBZ P02008 CARD10 Homo sapiens Q9BWT7
Validated Y2H
32296183
Intra
HBZ P02008 CARD10 Homo sapiens Q9BWT7
Y2H Array
32296183
Intra
HBZ P02008 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
HBZ P02008 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
HBZ P02008 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
HBZ P02008 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
HBZ P02008 HBD Homo sapiens P02042
Validated Y2H
25416956
Intra
HBZ P02008 HBD Homo sapiens P02042
Y2H Prey Pooling
25416956
Intra
HBZ P02008 HBD Homo sapiens P02042
Validated Y2H
32296183
Intra
HBZ P02008 HBD Homo sapiens P02042
Y2H Array
25416956
Intra
HBZ P02008 HBE1 Homo sapiens P02100
Validated Y2H
32296183
Intra
HBZ P02008 HNRNPK Homo sapiens P61978-2
Validated Y2H
32296183
Intra
HBZ P02008 HNRNPK Homo sapiens P61978-2
Y2H Array
32296183
Intra
HBZ P02008 HNRNPK Homo sapiens P61978-2
Y2H Prey Pooling
32296183
Intra
HBZ P02008 HBB Homo sapiens P68871
Y2H Array
25502805
Intra
HBZ P02008 HBB Homo sapiens P68871
Validated Y2H
32296183
Intra
HBZ P02008 HBB Homo sapiens P68871
Electrophoresis
6683087
Intra
HBZ P02008 HBB Homo sapiens P68871
Y2H Array
31515488
Intra
HBZ P02008 KHDRBS3 Homo sapiens O75525
Y2H Prey Pooling
32296183
Intra
HBZ P02008 KHDRBS3 Homo sapiens O75525
Y2H Array
32296183
Intra
HBZ P02008 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
HBZ P02008 KHDRBS2 Homo sapiens Q5VWX1
Y2H Array
25416956
Intra
HBZ P02008 KHDRBS2 Homo sapiens Q5VWX1
Y2H Prey Pooling
25416956
Intra
HBZ P02008 KHDRBS2 Homo sapiens Q5VWX1
Y2H Array
31515488
Intra
HBZ P02008 CCNDBP1 Homo sapiens O95273
Y2H Array
32296183
Intra
HBZ P02008 CCNDBP1 Homo sapiens O95273
Y2H Prey Pooling
32296183
Intra
HBZ P02008 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra
HBZ P02008 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra
HBZ P02008 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
31515488
Intra
HBZ P02008 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra
HBZ P02008 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
HBZ P02008 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra
HBZ P02008 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HBZ Proteins

Cat. No. Product Name Accession Purity
HY-P70242 Hemoglobin subunit zeta/HBAZ Protein, Human (His) P02008 (M1-R142) ≥95%

Related Diseases

Diseases Alias
Alpha-Thalassemia

Alpha Thalassemia

Alpha Thalassaemia

Alpha Plus Thalassemia

Thalassemia, Alpha-

Thalassemias, Alpha-

A-Thalassemia

Α-Thalassemia

A-THAL

Thalassemia

Alpha Thalassaemia Syndrome
T-Cell Adult Acute Lymphocytic Leukemia

Acute Adult T-Cell Leukemia-Lymphoma

Adult Precursor T Lymphoblastic Leukemia

Atll

T-Cell Adult Acute Lymphoblastic Leukemia
Thalassemia

Sickle-Cell Thalassemia With Crisis

Sickle-Cell Thalassemia Without Crisis

Thalassemia Hb-S Disease With Crisis

Thalassemia Hb-S Disease Without Crisis

Thalassemias

Hereditary Leptocytosis

Haemoglobin Thalassaemia Disorder

Thalassaemia Syndrome

Thalassaemia Nos

Thalassemia Variants
Adult T-Cell Leukemia/Lymphoma

Adult T-Cell Leukemia

Atll

Adult T-Cell Leukaemia

Adult T-Cell Leukaemia/Lymphoma

Adult T-Cell Lymphoma

T Cell Leukemia Lymphoma Adult

Leukemia-Lymphoma, Adult T-Cell

Leukemia, T-Cell

Adult T-Cell Lymphoma/Leukemia
Urethra Transitional Cell Carcinoma

Urethral Transitional Cell Carcinoma

Urethral Urothelial Carcinoma
Adult Acute Lymphocytic Leukemia

Adult Acute Lymphoid Leukemia

Adult All
Larynx Squamous Papilloma

Laryngeal Squamous Cell Papilloma
Tropical Spastic Paraparesis

Tropical Spastic Paraplegia

Ham/Tsp

Htlv-Associated Myelopathy

Tropical Spastic Paralysis

Htlv-1 Associated Myelopathy/Tropical Spastic Paraparesis

Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/Tropical Spastic Paraparesis

Htlv-1-Associated Myelopathy/Tropical Spastic Paraparesis

Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis

Human T-Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis

Tsp

Paraparesis Tropical Spastic

Paraparesis, Tropical Spastic
Hemoglobin H Disease

HBH

Hemoglobin H Disease, Nondeletional

Hemoglobin H Disease, Deletional

Alpha-Thalassemia Intermedia

Haemoglobin H Disease

Alpha-Thalassemia, Hemoglobin H Type

Hemoglobin H Disease, Deletional And Nondeletional

Alpha Thalassemia, Haemoglobin H Type

Alpha Thalassemia, Hemoglobin H Type

Haemoglobin H Disease, Deletional

Hbh Disease

Alpha-Thalassemia Hemoglobin H Type

Hemoglobin H Disease Deletional

Hemoglobin H Disease Non-Deletional

Alpha-Thalassemia

Alpha - /- - Or Mutational Forms Of Alpha-Thalassaemia

Alpha Thalassaemia Intermedia
Histiocytosis-Lymphadenopathy Plus Syndrome

H Syndrome

Histiocytosis With Joint Contractures And Sensorineural Deafness

Faisalabad Histiocytosis

Shml

Hjcd

Rosai-Dorfman Disease

Pigmented Hypertrichosis With Insulin-Dependent Diabetes Mellitus

Phid

Sinus Histiocytosis And Massive Lymphadenopathy

Familial Rosai-Dorfman Disease

Slc29a3 Spectrum Disorder

Sinus Histiocytosis With Massive Lymphadenopathy

Histiocytosis And Lymphadenopathy With Or Without Cutaneous, Cardiac, And/Or Endocrine Features, Joint Contractures, And/Or Deafness

Hyperpigmentation, Cutaneous, With Hypertrichosis, Hepatosplenomegaly, Heart Anomalies, And Hypogonadism With Or Without Hearing Loss

Rosai-Dorfman Disease, Familial

Cutaneous Hyperpigmentation With Hypertrichosis, Hepatosplenomegaly, Heart Anomalies, And Hypogonadism With Or Without Hearing Loss

Histiocytosis And Lymphadenopathy With Or Without Cutaneous, Cardiac, And/Or Endocrine Features, Joint Contractures And/Or Deafness

Rdd

Rosaï-Dorfman Disease

Slc29a3 Disorder

Destombes-Rosai-Dorfman Disease

Rosai-Dorfman-Destombes Disease

HLAS

Cutaneous Hyperpigmentation With Hypertrichosis Hepatosplenomegaly Heart Anomalies And Hypogonadism With Or Without Hearing Loss

Histiocytosis And Lymphadenopathy With Or Without Cutaneous Cardiac And/Or Endocrine Features Joint Contractures And/Or Deafness

H Disease

Sinus Histiocytosis
Spinal Cord Disease

Spinal Cord Diseases

Myelopathy

Bone Marrow Diseases
Skin Papilloma

Cutaneous Papilloma

Papilloma Of Skin

Papilloma Skin
Strongyloidiasis

Disseminated Strongyloidiasis

Anguilluliasis

Anguillulosis

Infection By Strongyloides

Threadworm Infection

Enterobiasis
Heinz Body Anemias

Heinz Body Anemia

Heinz Body Anemias, Alpha-

HEIBAN

Anemia, Heinz Body

Acquired Heinz Body Anemia
Hemoglobinopathy

Hemoglobinopathies
T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06036 HBZ Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HBZ MGD MGI:96019
Rattus norvegicus HBZ RGD RGD:1307486
Others HBZ NCBI