2. Gene
  3. HHEX - hematopoietically expressed homeobox Gene

HHEX - hematopoietically expressed homeobox Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HEX; PRH; HMPH; PRHX; HOX11L-PEN

Gene ID: 3087 | Gene type: protein coding

About HHEX

Cytogenetic location: 10q23.33 Genomic coordinates (GRCh38): 10:92,689,955-92,695,647 (from NCBI)

This gene has 4 transcripts (splice variants) and 116 orthologues. Broad expression in thyroid (RPKM 53.2), liver (RPKM 28.6) and 14 other tissues.

Summary

This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008]

HHEX Products(1)

mRNA Protein Name
NM_002729.5 NP_002720.1 hematopoietically-expressed homeobox protein HHEX
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding, bending IDA
IDA: Inferred from direct assay
18755198 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
20028982 GOA
enables DNA-binding transcription factor binding IDA
IDA: Inferred from direct assay
15187083 GOA
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
15016828 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15016828 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15016828 GOA
enables eukaryotic initiation factor 4E binding IDA
IDA: Inferred from direct assay
12554669 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10597310 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
16540119 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10871399 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
18755198 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA conformation change IDA
IDA: Inferred from direct assay
18755198 GOA
involved in mRNA export from nucleus IDA
IDA: Inferred from direct assay
12554669 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10871399 GOA
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12554669 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10871399 GOA
involved in poly(A)+ mRNA export from nucleus IMP
IMP: Inferred from mutant phenotype
12554669 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
20028982 GOA
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
20028982 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12655000 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20028982 GOA
involved in protein localization to nucleus IDA
IDA: Inferred from direct assay
18713067 GOA
involved in regulation of leukocyte proliferation IDA
IDA: Inferred from direct assay
12554669 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12554669 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12554669 GOA
part of protein-DNA complex IDA
IDA: Inferred from direct assay
18755198 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HHEX Protein Structure

Homeobox

Homeobox: Homeobox domain (142 - 194)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

hematopoietically-expressed homeobox protein HHEX

homeobox protein HEX

HHEX Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
HHEX Q03014 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
HHEX Q03014 KRTAP10-5 Homo sapiens P60370
Validated Y2H
25416956
Intra
HHEX Q03014 KRTAP10-5 Homo sapiens P60370
Y2H Prey Pooling
25416956
Intra
HHEX Q03014 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra
HHEX Q03014 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
Intra
HHEX Q03014 KRTAP10-7 Homo sapiens P60409
Y2H Array
25416956
Intra
HHEX Q03014 APOBEC3C Homo sapiens Q9NRW3
Y2H Array
32296183
Intra
HHEX Q03014 APOBEC3C Homo sapiens Q9NRW3
Validated Y2H
32296183
Intra
HHEX Q03014 APOBEC3C Homo sapiens Q9NRW3
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 PSTPIP1 Homo sapiens O43586
Y2H Array
32296183
Intra
HHEX Q03014 PSTPIP1 Homo sapiens O43586
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 ABI2 Homo sapiens Q9NYB9-2
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 ABI2 Homo sapiens Q9NYB9-2
Y2H Array
32296183
Intra
HHEX Q03014 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra
HHEX Q03014 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
HHEX Q03014 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
Intra
HHEX Q03014 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 ABI1 Homo sapiens Q8IZP0-5
Y2H Array
32296183
Intra
HHEX Q03014 ABI1 Homo sapiens Q8IZP0-5
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 ABI1 Homo sapiens Q8IZP0-5
Validated Y2H
32296183
Intra
HHEX Q03014 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
HHEX Q03014 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra
HHEX Q03014 TP53BP2 Homo sapiens Q05BL1
Validated Y2H
32296183
Intra
HHEX Q03014 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 KRTAP6-2 Homo sapiens Q3LI66
Validated Y2H
32296183
Intra
HHEX Q03014 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
HHEX Q03014 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 KRTAP5-7 Homo sapiens Q6L8G8
Validated Y2H
32296183
Intra
HHEX Q03014 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Array
32296183
Intra
HHEX Q03014 KRTAP10-6 Homo sapiens P60371
Y2H Array
32296183
Intra
HHEX Q03014 KRTAP10-6 Homo sapiens P60371
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 KRTAP6-1 Homo sapiens Q3LI64
Validated Y2H
32296183
Intra
HHEX Q03014 KRTAP6-1 Homo sapiens Q3LI64
Y2H Array
32296183
Intra
HHEX Q03014 KRTAP6-1 Homo sapiens Q3LI64
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 KRTAP5-8 Homo sapiens O75690
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 KRTAP5-8 Homo sapiens O75690
Y2H Array
32296183
Intra
HHEX Q03014 KRTAP19-1 Homo sapiens Q8IUB9
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 KRTAP19-1 Homo sapiens Q8IUB9
Validated Y2H
32296183
Intra
HHEX Q03014 KRTAP19-1 Homo sapiens Q8IUB9
Y2H Array
32296183
Intra
HHEX Q03014 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra
HHEX Q03014 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 KRTAP2-4 Homo sapiens Q9BYR9
Validated Y2H
32296183
Intra
HHEX Q03014 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
HHEX Q03014 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
Intra
HHEX Q03014 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 PFDN5 Homo sapiens Q99471
Validated Y2H
32296183
Intra
HHEX Q03014 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
HHEX Q03014 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra
HHEX Q03014 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
HHEX Q03014 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
HHEX Q03014 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
HHEX Q03014 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
HHEX Q03014 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
HHEX Q03014 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 KHDRBS2 Homo sapiens Q5VWX1
Validated Y2H
32296183
Intra
HHEX Q03014 KHDRBS2 Homo sapiens Q5VWX1
Y2H Array
32296183
Intra
HHEX Q03014 KHDRBS2 Homo sapiens Q5VWX1
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 RBMY1F Homo sapiens Q15415
Y2H Prey Pooling
32296183
Intra
HHEX Q03014 RBMY1F Homo sapiens Q15415
Validated Y2H
32296183
Intra
HHEX Q03014 RBMY1F Homo sapiens Q15415
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

HHEX Antibodies

Cat. No. Product Name Application Reactivity
HY-P82157 Hex Antibody (YA1902) WB, IP Human

Related Diseases

Diseases Alias
Intermittent Proptosis

Intermittent Exophthalmos
Cyclotropia
Heart Defects, Congenital, And Other Congenital Anomalies

Pancreatic Hypoplasia-Diabetes-Congenital Heart Disease Syndrome

Pancreatic Agenesis And Congenital Heart Defects

HDCA

PACHD

Congenital Pancreatic Hypoplasia With Diabetes Mellitus And Congenital Heart Disease

Yorifuji-Okuno Syndrome

Yorifuji Okuno Syndrome

Pancreatic Hypoplasia, Congenital, With Diabetes Mellitus And Congenital Heart Disease

Congenital Heart Defects And Other Congenital Anomalies

Hereditary Pancreatic Hypoplasia, Diabetes Mellitus And Congenital Heart Disease

Congenital Pancreatic Agenesis With Diabetes Mellitus And Congenital Heart Disease

Heart Disease, Congenital, And Other Congenital Anomalies
Wolfram Syndrome 1

WFS1

Didmoad

Wfs

Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome

Wolfram Syndrome
Thyroid Malformation
Psammomatous Meningioma
Sandhoff Disease

Total Hexosaminidase Deficiency

Hexosaminidases A And B Deficiency

Sandhoff Disease, Infantile, Juvenile, And Adult Forms

Beta-Hexosaminidase-Beta-Subunit Deficiency

Gm2 Gangliosidosis, Type 2

Hexosaminidase A And B Deficiency Disease

Sandhoff-Jatzkewitz-Pilz Disease

Gm2 Gangliosidosis, Type Ii

Sandhoff Disease, Infantile Form

Sandhoff Disease, Adult Form

Sandhoff Disease, Juvenile Form

Gm2-Gangliosidosis, Type Ii

Sandhoff Jatzkewitz Disease

Type Ii Gm2 Gangliosidosis

Gm2 Gangliosidosis, 0 Variant

Gm2 Gangliosidosis 0 Variant

Hexosaminidases A And B Deficiency, Infantile Form

Infantile Gm2 Gangliosidosis 0 Variant

Adult Gm2 Gangliosidosis 0 Variant

Hexosaminidases A And B Deficiency, Adult Form

Hexosaminidases A And B Deficiency, Juvenile Form

Juvenile Gm2 Gangliosidosis 0 Variant

Gm2-Gangliosidosis 2

GM2G2

Hexosaminidase A And B Deficiency

Sd
Gm2 Gangliosidosis

Gangliosidosis Gm2

Gangliosidoses, Gm2
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
Diabetes Mellitus

Diabetes
Tay-Sachs Disease

Hexosaminidase A Deficiency

TSD

Hexa Deficiency

Gm2 Gangliosidosis, Type 1

Hexosaminidase Alpha-Subunit Deficiency

Gm2-Gangliosidosis, Several Forms

Gm2-Gangliosidosis, B, B1, Ab Variant

B Variant Gm2 Gangliosidosis

Sphingolipidosis, Tay-Sachs

Gm2-Gangliosidosis, Type I

B Variant Gm2-Gangliosidosis

Hex A Pseudodeficiency

Hexa Disorders

Beta-Hexosaminidase A Deficiency

Gm2 Gangliosidosis, Type I

Gangliosidosis Gm2 , Type 1

Gm2 Gangliosidosis, B, B1 Variant

Gm2-Gangliosidosis 1

GM2G1

Gm2-Gangliosidosis B Variant

Tay-Sachs Disease Pseudo-Ab Variant

Tay-Sachs Disease Variant B1

Gangliosidoses, Gm2
Wolfram Syndrome

Didmoad Syndrome

Didmoad

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

Wfs

Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness

Didmoadud

Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome

Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Congenital Hypothyroidism

Cretinism

Neonatal Hypothyroidism

Ch

Cht

Congenital Myxedema

Myxedema, Congenital

Endemic Cretinism

Congenital Iodine-Deficiency Syndrome

Fetal Iodine Deficiency Syndrome

Congenital Iodine-Deficiency Hypothyroidism Nos
Polycystic Liver Disease

Autosomal Dominant Polycystic Liver Disease

Isolated Polycystic Liver Disease

Pcld

Congenital Cystic Liver Disease

Congenital Hepatic Cyst

Fibrocystic Liver Disease

Isolated Autosomal Dominant Polycystic Liver Disease

Adpcld

Liver Disease, Polycystic

Multiple Cysts Of Liver

Pld - [Polycystic Liver Disease]

Polycystic Liver Disorder

Polycystic Liver

Congenital Polycystic Disease Of Liver

Congenital Polycystic Liver Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06159 HHEX Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HHEX VGNC VGNC:41680
Rattus norvegicus HHEX RGD RGD:619932
Mus musculus HHEX MGD MGI:96086
Felis catus HHEX VGNC VGNC:67568
Macaca mulatta HHEX VGNC VGNC:73376
Bos taurus HHEX VGNC VGNC:29839