ANXA7 - annexin A7 Gene

Homo sapiens

Also known as SNX; ANX7; SYNEXIN

Gene ID: 310 | Gene type: protein coding

About ANXA7

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:73,375,101-73,414,058 (from NCBI)

This gene has 5 transcripts (splice variants), 163 orthologues and 12 paralogues. Ubiquitous expression in thyroid (RPKM 52.9), kidney (RPKM 46.7) and 25 other tissues.

Summary

Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 Amino acids and a conserved C-terminal region of 299 Amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive Calcium Channel activity, ion selectivity and membrane fusion. [provided by RefSeq, Jul 2008]

ANXA7 Products(4)

mRNA	Protein	Name
NM_001156.5	NP_001147.1	annexin A7 isoform 1
NM_001320879.2	NP_001307808.1	annexin A7 isoform 4
NM_001320880.2	NP_001307809.1	annexin A7 isoform 3
NM_004034.4	NP_004025.1	annexin A7 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	12445460	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	24007983	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9268363	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagy	IMP IMP: Inferred from mutant phenotype	24007983	GOA
involved in epithelial cell differentiation	IEP IEP: Inferred from expression pattern	21492153	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24007983	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with chromaffin granule membrane	IDA IDA: Inferred from direct assay	9268363	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	10672515	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10672515	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANXA7 Protein Structure

Annexin

0
100
200
300
400
488 a.a.

Protein Preferred Names

Protein Names

annexin A7

annexin VII

ANXA7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ANXA7	P20073	SRI	Homo sapiens	P30626-1	SPR	17699613

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ANXA7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7519	Annexin A7/ANXA7 Protein, Human	P20073-2 (M1-Q488)	≥95%

ANXA7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81393	Annexin VII Antibody (YA1138)	IHC-P	Human

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-115635	ABO hydrochloride	Modulator	98.7%	Phase 4
HY-125355	SEC	Inducer	98.26%	Phase 1

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00767	ANXA7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ANXA7	MGD	MGI:88031
Felis catus	ANXA7	VGNC	VGNC:67707
Rattus norvegicus	ANXA7	RGD	RGD:621173
Macaca mulatta	ANXA7	VGNC	VGNC:69952
Bos taurus	ANXA7	VGNC	VGNC:25969
Canis familiaris	ANXA7	VGNC	VGNC:37944
Others	ANXA7	NCBI

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