Csk - C-terminal Src kinase Gene

Rattus norvegicus

Gene ID: 315707 | Gene type: protein coding

About Csk

Summary

Enables proline-rich region binding activity; protein Phosphatase binding activity; and protein tyrosine kinase activity. Involved in several processes, including central nervous system development; negative regulation of bone resorption; and regulation of MAPK cascade. Located in cytoplasm and membrane raft. Biomarker of hepatocellular carcinoma. Orthologous to human CSK (C-terminal Src kinase). [provided by Alliance of Genome Resources, Apr 2022]

Csk Products(1)

mRNA	Protein	Name
NM_001030039.1	NP_001025210.1	tyrosine-protein kinase CSK

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables proline-rich region binding	IPI IPI: Inferred from physical interaction	8890164	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	21873224	RGD
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	8890164	RGD
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7683130	RGD
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	12700184	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adherens junction organization	IEP IEP: Inferred from expression pattern	15389520	RGD
involved in cellular response to peptide hormone stimulus	IDA IDA: Inferred from direct assay	17071733	RGD
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	9325302	RGD
involved in negative regulation of bone resorption	IDA IDA: Inferred from direct assay	10411542	RGD
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10411542	RGD
involved in negative regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	10411542	RGD
involved in negative regulation of kinase activity	IDA IDA: Inferred from direct assay	10411542	RGD
involved in negative regulation of low-density lipoprotein particle clearance	IDA IDA: Inferred from direct assay	10884975	RGD
involved in negative regulation of phagocytosis	IDA IDA: Inferred from direct assay	10884975	RGD
involved in oligodendrocyte differentiation	IEP IEP: Inferred from expression pattern	15504915	RGD
involved in positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	10884975	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	7683130	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	7683130	RGD
involved in regulation of Fc receptor mediated stimulatory signaling pathway	IDA IDA: Inferred from direct assay	9325302	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21873224	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tyrosine-protein kinase CSK

C-SRC kinase	CSK, non-receptor tyrosine kinase
c-src tyrosine kinase	protein-tyrosine kinase (CSK)

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15196	TAK-285	Inhibitor	99.70%	Phase 1

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1180A	Pam3CSK4 TFA	Agonist	99.66%	Unkown
HY-108471	CU-CPT22	Inhibitor	≥99.0%	Unkown
HY-112146	MMG-11	Antagonist	99.24%	Unkown
HY-130254	CSK-IN-1	Inhibitor	98.61%	Unkown
HY-122113	PD173952		99.44%	Unkown
HY-P1181A	Pam2CSK4 TFA	Agonist	99.28%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-137345	DB-3-291	Inhibitor	98.03%	Unkown
HY-130504	Propargyl-PEG1-acid		≥97.0%	Unkown
HY-112146A	MMG-11 quarterhydrate	Antagonist	98.70%	Unkown
HY-P1180	Pam3CSK4	Agonist	/	Unkown
HY-118105	RK-20448	Inhibitor	99.38%	Unkown
HY-P10527	CSK substrate		/	Unkown
HY-P1180B	Pam3CSK4 trihydrochloride		/	Unkown
HY-P1181	Pam2CSK4	Agonist	/	Unkown
HY-P1405	Pam3CSK4-Biotin	Agonist	/	Unkown
HY-RS03238	CSK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W114420	3-Methyl-L-tyrosine		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Csk	NCBI	NCBI:1445
Macaca fascicularis	Csk	NCBI	NCBI:102131034
Mus musculus	Csk	NCBI	NCBI:12988
Macaca mulatta	Csk	NCBI	NCBI:702868

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