CSK - C-terminal Src kinase Gene

Homo sapiens

Gene ID: 1445 | Gene type: protein coding

About CSK

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,782,080-74,803,197 (from NCBI)

This gene has 14 transcripts (splice variants), 279 orthologues and 32 paralogues. Broad expression in lymph node (RPKM 63.0), spleen (RPKM 47.7) and 24 other tissues.

Summary

The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine Phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the Src proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

CSK Products(13)

mRNA	Protein	Name
NM_001127190.2	NP_001120662.1	tyrosine-protein kinase CSK isoform 1
NM_001354988.2	NP_001341917.1	tyrosine-protein kinase CSK isoform 1
NM_001387089.1	NP_001374018.1	tyrosine-protein kinase CSK isoform 1
NM_001387090.1	NP_001374019.1	tyrosine-protein kinase CSK isoform 1
NM_001387091.1	NP_001374020.1	tyrosine-protein kinase CSK isoform 1
NM_001387092.1	NP_001374021.1	tyrosine-protein kinase CSK isoform 1
NM_001387093.1	NP_001374022.1	tyrosine-protein kinase CSK isoform 1
NM_001387094.1	NP_001374023.1	tyrosine-protein kinase CSK isoform 6
NM_001387095.1	NP_001374024.1	tyrosine-protein kinase CSK isoform 2
NM_001387096.1	NP_001374025.1	tyrosine-protein kinase CSK isoform 3
NM_001387097.1	NP_001374026.1	tyrosine-protein kinase CSK isoform 4
NM_001387098.1	NP_001374027.1	tyrosine-protein kinase CSK isoform 5
NM_004383.3	NP_004374.1	tyrosine-protein kinase CSK isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	19888460	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7507203	GOA
enables protein kinase A catalytic subunit binding	IPI IPI: Inferred from physical interaction	17911601	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of Golgi to plasma membrane protein transport	IDA IDA: Inferred from direct assay	20605918	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IPI IPI: Inferred from physical interaction	10790433	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSK Protein Structure

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
450 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase CSK

C-Src kinase

CSK Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CSK	P41240	PTPRC	Homo sapiens	P08575	Phosphatase Assay	19167335
Intra	CSK	P41240	FRK	Homo sapiens	P42685	TAP	23455922
Intra	CSK	P41240	FRK	Homo sapiens	P42685	Anti Tag CoIP	28514442
Intra	CSK	P41240	PAG1	Homo sapiens	Q9NWQ8	Pull Down	10790433
Intra	CSK	P41240	TNS2	Homo sapiens	Q63HR2	TAP	23455922
Intra	CSK	P41240	PAG1	Homo sapiens	Q9NWQ8	Anti Tag CoIP	33961781
Intra	CSK	P41240	TNS3	Homo sapiens	Q68CZ2	Anti Tag CoIP	31980649
Intra	CSK	P41240	PAG1	Homo sapiens	Q9NWQ8	Anti Tag CoIP	28514442
Intra	CSK	P41240	TNS2	Homo sapiens	Q63HR2	Pull Down	32707033
Intra	CSK	P41240	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	CSK	P41240	PAG1	Homo sapiens	Q9NWQ8	Pull Down	32707033
Intra	CSK	P41240	FRK	Homo sapiens	P42685	Anti Tag CoIP	33961781
Intra	CSK	P41240	IGF1R	Homo sapiens	P08069	Y2H	10026153
Intra	CSK	P41240	IGF1R	Homo sapiens	P08069	CoIP	10026153
Intra	CSK	P41240	PXN	Homo sapiens	P49023	Anti Bait CoIP	14665621
Intra	CSK	P41240	PXN	Homo sapiens	P49023	Anti Tag CoIP	31980649
Intra	CSK	P41240	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	CSK	P41240	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	CSK	P41240	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	CSK	P41240	KANK4	Homo sapiens	Q5T7N3	Y2H Array	32296183
Intra	CSK	P41240	KANK4	Homo sapiens	Q5T7N3	Y2H Prey Pooling	32296183
Intra	CSK	P41240	KANK4	Homo sapiens	Q5T7N3	Validated Y2H	32296183
Cross	CSK	P41240	SRC	Gallus gallus	P00523	X-Ray Diffraction	18614016
Cross	CSK	P41240	SRC	Gallus gallus	P00523	Protein Kinase Assay	15683240
Cross	CSK	P41240	SRC	Gallus gallus	P00523	SPR	18614016
Cross	CSK	P41240	lspA1	Haemophilus ducreyi	Q7VLE8	Protein Kinase Assay	24902122
Cross	CSK	P41240	lspA1	Haemophilus ducreyi	Q7VLE8	Pull Down	24902122

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CSK Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72956	CSK Protein, Human (sf9, GST)	P41240 (M1-L450)	≥95%

Related Diseases

Diseases

Alias

Osteopetrosis

Marble Bone Disease	Albers-Schonberg Disease
Osteopetroses	Marble Bones
Osteopetrosis And Related Disorders	Congenital Osteopetrosis
Marble Bone	Albers-Schoenberg Disease
Albers-Schonberg Osteopetrosis	Osteosclerosis Fragilis
Ivory Bones

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Cd45 Deficiency

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15196	TAK-285	Inhibitor	99.70%	Phase 1

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1180A	Pam3CSK4 TFA	Agonist	99.66%	Unkown
HY-108471	CU-CPT22	Inhibitor	≥99.0%	Unkown
HY-112146	MMG-11	Antagonist	99.11%	Unkown
HY-130254	CSK-IN-1	Inhibitor	98.61%	Unkown
HY-122113	PD173952		99.44%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-P1181A	Pam2CSK4 TFA	Agonist	99.28%	Unkown
HY-137345	DB-3-291	Inhibitor	98.03%	Unkown
HY-130504	Propargyl-PEG1-acid		≥97.0%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-112146A	MMG-11 quarterhydrate	Antagonist	99.09%	Unkown
HY-P1180	Pam3CSK4	Agonist	/	Unkown
HY-118105	RK-20448	Inhibitor	99.38%	Unkown
HY-P10527	CSK substrate		/	Unkown
HY-P1180B	Pam3CSK4 trihydrochloride		/	Unkown
HY-P1181	Pam2CSK4	Agonist	/	Unkown
HY-P1405	Pam3CSK4-Biotin	Agonist	/	Unkown
HY-RS03238	CSK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CSK	RGD	RGD:1308800
Mus musculus	CSK	MGD	MGI:88537
Macaca mulatta	CSK	VGNC	VGNC:81380
Canis familiaris	CSK	VGNC	VGNC:39661
Felis catus	CSK	VGNC	VGNC:61220
Bos taurus	CSK	VGNC	VGNC:27761
Macaca fascicularis	CSK	NCBI	NCBI:102131034
Others	CSK	NCBI

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