2. Gene
  3. HNRNPD - heterogeneous nuclear ribonucleoprotein D Gene

HNRNPD - heterogeneous nuclear ribonucleoprotein D Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as P37; AUF1; AUF1A; HNRPD; hnRNPD0

Gene ID: 3184 | Gene type: protein coding

About HNRNPD

Cytogenetic location: 4q21.22 Genomic coordinates (GRCh38): 4:82,352,498-82,373,991 (from NCBI)

This gene has 18 transcripts (splice variants), 198 orthologues, 36 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 80.4), bone marrow (RPKM 72.5) and 25 other tissues.

Summary

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and Other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]

HNRNPD Products(4)

mRNA Protein Name
NM_001003810.2 NP_001003810.1 heterogeneous nuclear ribonucleoprotein D0 isoform d
NM_002138.4 NP_002129.2 heterogeneous nuclear ribonucleoprotein D0 isoform c
NM_031369.3 NP_112737.1 heterogeneous nuclear ribonucleoprotein D0 isoform b
NM_031370.3 NP_112738.1 heterogeneous nuclear ribonucleoprotein D0 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA binding IDA
IDA: Inferred from direct assay
8321232 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12107167 GOA
enables telomeric DNA binding IDA
IDA: Inferred from direct assay
8321232 GOA
Biological Process GO Annotation Evidence Reference Source
involved in CRD-mediated mRNA stabilization IDA
IDA: Inferred from direct assay
11051545 GOA
involved in circadian regulation of translation IMP
IMP: Inferred from mutant phenotype
24423872 GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
IDA: Inferred from direct assay
11051545 GOA
involved in positive regulation of cytoplasmic translation IDA
IDA: Inferred from direct assay
11051545 GOA
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
24423872 GOA
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
24423872 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
11051545 GOA
part of mCRD-mediated mRNA stability complex IPI
IPI: Inferred from physical interaction
11051545 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
17289661 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HNRNPD Protein Structure

CBFNT

CBFNT: CBFNT (NUC161) domain (1 - 79)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (100 - 167)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (184 - 243)

  • 0
  • 100
  • 200
  • 300
  • 355 a.a.
Protein Preferred Names Protein Names

heterogeneous nuclear ribonucleoprotein D0

ARE-binding protein AUFI, type A

HNRNPD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
HNRNPD Q14103 LDHAL6B Homo sapiens Q9BYZ2
Density Sedimentation
12107167
Intra
HNRNPD Q14103 ING4 Homo sapiens Q9UNL4
Anti Bait CoIP
23603392
Intra
HNRNPD Q14103 HNRNPA2B1 Homo sapiens P22626
Crosslink
30021884
Intra
HNRNPD Q14103 HNRNPA2B1 Homo sapiens P22626
Anti Tag CoIP
26496610
Intra
HNRNPD Q14103 HNRNPA2B1 Homo sapiens P22626
Anti Tag CoIP
35271311
Intra
HNRNPD Q14103 HNRNPDL Homo sapiens O14979
Anti Tag CoIP
35271311
Intra
HNRNPD Q14103 HNRNPU Homo sapiens Q00839
Anti Tag CoIP
26496610
Intra
HNRNPD Q14103 HNRNPU Homo sapiens Q00839
Anti Tag CoIP
35271311
Intra
HNRNPD Q14103 HNRNPC Homo sapiens P07910
Anti Tag CoIP
35271311
Intra
HNRNPD Q14103 HNRNPC Homo sapiens P07910
Y2H
22365833
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ulcerative Blepharitis
Chromosome 4q21 Deletion Syndrome

4q21 Microdeletion Syndrome

Monosomy 4q21

Del(4)(Q21)

Chromosome Deletion Syndrome 4q21
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06267 HNRNPD Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HNRNPD VGNC VGNC:54954
Bos taurus HNRNPD VGNC VGNC:52786
Mus musculus HNRNPD MGD MGI:101947
Felis catus HNRNPD VGNC VGNC:67606
Rattus norvegicus HNRNPD RGD RGD:620365
Macaca mulatta HNRNPD VGNC VGNC:106590